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Volumn 8, Issue 12, 2008, Pages 1885-1896

Immune tolerance induction for the eradication of inhibitors in patients with hemophilia A

Author keywords

Factor VIII; Hemophilia; Immune tolerance induction; Inhibitors

Indexed keywords

ACTIVATED PROTHROMBIN COMPLEX; BLOOD CLOTTING FACTOR 8; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 4; PREDNISONE; RECOMBINANT BLOOD CLOTTING FACTOR 8; RITUXIMAB; TUMOR NECROSIS FACTOR ALPHA;

EID: 57649158211     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712590802515537     Document Type: Review
Times cited : (3)

References (113)
  • 1
    • 33645972890 scopus 로고    scopus 로고
    • Comparative study of validity of clinical, X-ray and magnetic resonance imaging scores in evaluation and management of haemophilic arthropathy in children
    • Pergantou H, Matsinos G, Papadopoulos A, et al. Comparative study of validity of clinical, X-ray and magnetic resonance imaging scores in evaluation and management of haemophilic arthropathy in children. Haemophilia 2006;12:241-7
    • (2006) Haemophilia , vol.12 , pp. 241-247
    • Pergantou, H.1    Matsinos, G.2    Papadopoulos, A.3
  • 2
    • 57649154035 scopus 로고    scopus 로고
    • Bleeding and clotting disorders surveillance
    • Available from
    • CDC: Bleeding and clotting disorders surveillance. Summary report of UDC activity. Available from: http://www2a.cdc.gov/ncbddd/htcweb/UDC_Report/ UDC_view1.asp?para1= NATION¶2=TREATH¶3= &ScreenWidth=1920&ScreenHeight=1200
    • Summary report of UDC activity
  • 3
    • 0035077234 scopus 로고    scopus 로고
    • Definitions in hemophilia: Recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Thrombosis and Haemostasis
    • White GC, Rosendaal F, Aledort LM, et al. Definitions in hemophilia: recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Thrombosis and Haemostasis. Thromb Haemost 2001;85:560
    • (2001) Thromb Haemost , vol.85 , pp. 560
    • White, G.C.1    Rosendaal, F.2    Aledort, L.M.3
  • 5
    • 57649145661 scopus 로고    scopus 로고
    • Medical and Scientific Advisory Council Recommendation Concerning Prophylaxis (Regular Administration of Clotting Factor Concentrate to Prevent Bleeding)
    • MASAC:, National Hemophilia Foundation, Available from:, last accessed 12 August 2008
    • MASAC: Medical and Scientific Advisory Council Recommendation Concerning Prophylaxis (Regular Administration of Clotting Factor Concentrate to Prevent Bleeding). MASAC Recommendation 170. National Hemophilia Foundation 2006. Available from: http://www.hemophilia.org/NHFWeb/ MainPgs/MainNHF.aspx?menuid=57&contentid=1007 [last accessed 12 August 2008]
    • (2006) MASAC Recommendation , vol.170
  • 6
    • 34447124678 scopus 로고    scopus 로고
    • Comparing prophylaxis with episodic treatment in haemophilia A: Implications for clinical practice
    • Manco-Johnson M. Comparing prophylaxis with episodic treatment in haemophilia A: implications for clinical practice. Haemophilia 2007;13(Suppl 2):4-9
    • (2007) Haemophilia , vol.13 , Issue.SUPPL. 2 , pp. 4-9
    • Manco-Johnson, M.1
  • 7
    • 84949470041 scopus 로고    scopus 로고
    • Immune tolerance: High-dose regimen
    • Rodriguez-Merchan EC, Lee CA, editors, Oxford: Blackwell;
    • Brackmann HH, Wallny T. Immune tolerance: high-dose regimen. In: Rodriguez-Merchan EC, Lee CA, editors. Inhibitors in patients with hemophilia. Oxford: Blackwell; 2002. p. 45-8
    • (2002) Inhibitors in patients with hemophilia , pp. 45-48
    • Brackmann, H.H.1    Wallny, T.2
  • 8
    • 0031958313 scopus 로고    scopus 로고
    • Factor VIII inhibitors in mild and moderate-severity haemophilia A. UK Haemophilia Centre Directors Organisation
    • Hay CR, Ludlam CA, Colvin BT, et al. Factor VIII inhibitors in mild and moderate-severity haemophilia A. UK Haemophilia Centre Directors Organisation. Thromb Haemost 1998;79:762-6
    • (1998) Thromb Haemost , vol.79 , pp. 762-766
    • Hay, C.R.1    Ludlam, C.A.2    Colvin, B.T.3
  • 9
    • 0027985567 scopus 로고
    • Inhibitors in hemophilia patients: Current status and management
    • Aledort L. Inhibitors in hemophilia patients: current status and management. Am J Hematol 1994;47:208-17
    • (1994) Am J Hematol , vol.47 , pp. 208-217
    • Aledort, L.1
  • 10
    • 0028266130 scopus 로고
    • A multicenter study of recombinant factor VIII (Recombinate): Safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A. The Recombinate Study Group
    • Bray GL, Gomperts ED, Courter S, et al. A multicenter study of recombinant factor VIII (Recombinate): safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A. The Recombinate Study Group. Blood 1994;83:2428-35
    • (1994) Blood , vol.83 , pp. 2428-2435
    • Bray, G.L.1    Gomperts, E.D.2    Courter, S.3
  • 11
    • 34250708408 scopus 로고    scopus 로고
    • Treatment characteristics and the risk of inhibitor development: A multi-center cohort study among previously untreated patients with severe hemophilia A
    • Gouw SC, van den Berg HM, le Cessie S, et al. Treatment characteristics and the risk of inhibitor development: a multi-center cohort study among previously untreated patients with severe hemophilia A. J Thromb Haemost 2007;5:1383-90
    • (2007) J Thromb Haemost , vol.5 , pp. 1383-1390
    • Gouw, S.C.1    van den Berg, H.M.2    le Cessie, S.3
  • 12
    • 57649214536 scopus 로고    scopus 로고
    • Kasper CK. Diagnosis and management of inhibitors to factors VIII and IX. An introductory discussion for physicians. Treatment of Hemophilia. World Federation of Hemophilia; September 2004, no. 34
    • Kasper CK. Diagnosis and management of inhibitors to factors VIII and IX. An introductory discussion for physicians. Treatment of Hemophilia. World Federation of Hemophilia; September 2004, no. 34
  • 13
    • 36349021392 scopus 로고    scopus 로고
    • T-cell responses over time in a mild hemophilia A inhibitor subject: Epitope identification and transient immunogenicity of the corresponding self-peptide
    • James EA, Kwok WW, Ettinger RA, et al. T-cell responses over time in a mild hemophilia A inhibitor subject: epitope identification and transient immunogenicity of the corresponding self-peptide. J Thromb Haemost 2007;5:2399-407
    • (2007) J Thromb Haemost , vol.5 , pp. 2399-2407
    • James, E.A.1    Kwok, W.W.2    Ettinger, R.A.3
  • 14
    • 1642356200 scopus 로고    scopus 로고
    • Inhibitors in hemophilia A: Mechanisms of inhibition, management and perspectives
    • Ananyeva NM, Lacroix-Desmazes S, Hauser CA, et al. Inhibitors in hemophilia A: mechanisms of inhibition, management and perspectives. Blood Coagul Fibrinolysis 2004;15:109-24
    • (2004) Blood Coagul Fibrinolysis , vol.15 , pp. 109-124
    • Ananyeva, N.M.1    Lacroix-Desmazes, S.2    Hauser, C.A.3
  • 15
    • 20244363765 scopus 로고    scopus 로고
    • Catalytic activity of antibodies against factor VIII in patients with hemophilia A
    • Lacroix-Desmazes S, Moreau A, Sooryanarayana, et al. Catalytic activity of antibodies against factor VIII in patients with hemophilia A. Nat Med 1999;5:1044-7
    • (1999) Nat Med , vol.5 , pp. 1044-1047
    • Lacroix-Desmazes, S.1    Moreau, A.2    Sooryanarayana3
  • 16
    • 0027488655 scopus 로고
    • Anti-factor VIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotypic restriction
    • Gilles JG, Arnout J, Vermylen J, et al. Anti-factor VIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotypic restriction. Blood 1993;82:2452-61
    • (1993) Blood , vol.82 , pp. 2452-2461
    • Gilles, J.G.1    Arnout, J.2    Vermylen, J.3
  • 17
    • 0029887497 scopus 로고    scopus 로고
    • High incidence of anti-FVIII antibodies against non-coagulant epitopes in haemophilia A patients: A possible role for the half-life of transfused FVIII
    • Dazzi F, Tison T, Vianello F, et al. High incidence of anti-FVIII antibodies against non-coagulant epitopes in haemophilia A patients: a possible role for the half-life of transfused FVIII. Br J Haematol 1996;93:688-93
    • (1996) Br J Haematol , vol.93 , pp. 688-693
    • Dazzi, F.1    Tison, T.2    Vianello, F.3
  • 18
    • 0028887956 scopus 로고
    • Dendritic cells are the most efficient in presenting endogenous naturally processed self-epitopes to class II-restricted T cells
    • Guery JC, Adorini L. Dendritic cells are the most efficient in presenting endogenous naturally processed self-epitopes to class II-restricted T cells. J Immunol 1995;154:536-44
    • (1995) J Immunol , vol.154 , pp. 536-544
    • Guery, J.C.1    Adorini, L.2
  • 19
    • 0021979942 scopus 로고
    • Antigen presenting cells and mechanisms of antigen presentation
    • Chesnut RW, Grey HM. Antigen presenting cells and mechanisms of antigen presentation. Crit Rev Immunol 1985;5:263-316
    • (1985) Crit Rev Immunol , vol.5 , pp. 263-316
    • Chesnut, R.W.1    Grey, H.M.2
  • 20
    • 0034853666 scopus 로고    scopus 로고
    • Processing and presentation of antigens by dendritic cells: Implications for vaccines
    • Bhardwaj N. Processing and presentation of antigens by dendritic cells: implications for vaccines. Trends Mol Med 2001;7:388-94
    • (2001) Trends Mol Med , vol.7 , pp. 388-394
    • Bhardwaj, N.1
  • 21
    • 33846244931 scopus 로고    scopus 로고
    • VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors
    • Dasgupta S, Repesse Y, Bayry J, et al. VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors. Blood 2007;109:610-2
    • (2007) Blood , vol.109 , pp. 610-612
    • Dasgupta, S.1    Repesse, Y.2    Bayry, J.3
  • 22
    • 47649092909 scopus 로고    scopus 로고
    • Dynamics of factor VIII interactions determine its immunological fate in hemophilia A
    • Lacroix-Desmazes S, Navarrete AM, Andre S, et al. Dynamics of factor VIII interactions determine its immunological fate in hemophilia A. Blood 2008;112:240-9
    • (2008) Blood , vol.112 , pp. 240-249
    • Lacroix-Desmazes, S.1    Navarrete, A.M.2    Andre, S.3
  • 23
    • 37149017979 scopus 로고    scopus 로고
    • Factor VIII inhibitors: Role of von Willebrand factor on the uptake of factor VIII by dendritic cells
    • Kaveri SV, Dasgupta S, Andre S, et al. Factor VIII inhibitors: role of von Willebrand factor on the uptake of factor VIII by dendritic cells. Haemophilia 2007;13(Suppl 5):61-4
    • (2007) Haemophilia , vol.13 , Issue.SUPPL. 5 , pp. 61-64
    • Kaveri, S.V.1    Dasgupta, S.2    Andre, S.3
  • 24
    • 33845485057 scopus 로고    scopus 로고
    • Mechanisms of action of immune tolerance induction against factor VIII in patients with congenital haemophilia A and factor VIII inhibitors
    • Reipert BM, van Helden PM, Schwarz HP, et al. Mechanisms of action of immune tolerance induction against factor VIII in patients with congenital haemophilia A and factor VIII inhibitors. Br J Haematol 2007;136:12-25
    • (2007) Br J Haematol , vol.136 , pp. 12-25
    • Reipert, B.M.1    van Helden, P.M.2    Schwarz, H.P.3
  • 26
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky K. Clonal selection and learning in the antibody system. Nature 1996;381:751-8
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 27
    • 27744498868 scopus 로고    scopus 로고
    • Follicular B helper T cells in antibody responses and autoimmunity
    • Vinuesa CG, Tangye SG, Moser B, et al. Follicular B helper T cells in antibody responses and autoimmunity. Nat Rev Immunol 2005;5:853-65
    • (2005) Nat Rev Immunol , vol.5 , pp. 853-865
    • Vinuesa, C.G.1    Tangye, S.G.2    Moser, B.3
  • 28
    • 0032725319 scopus 로고    scopus 로고
    • CD4+ T cell response to factor VIII in hemophilia A, acquired hemophilia, and healthy subjects
    • Reding MT, Wu H, Krampf M, et al. CD4+ T cell response to factor VIII in hemophilia A, acquired hemophilia, and healthy subjects. Thromb Haemost 1999;82:509-15
    • (1999) Thromb Haemost , vol.82 , pp. 509-515
    • Reding, M.T.1    Wu, H.2    Krampf, M.3
  • 29
    • 34547430130 scopus 로고    scopus 로고
    • A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes
    • Dasgupta S, Navarrete AM, Bayry J, et al. A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes. Proc Natl Acad Sci USA 2007;104:8965-70
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 8965-8970
    • Dasgupta, S.1    Navarrete, A.M.2    Bayry, J.3
  • 30
    • 6644227418 scopus 로고    scopus 로고
    • The Malmö International Brother Study (MIBS): Further support for genetic predisposition to inhibitor development in hemophilia patients
    • Astermark J, Berntorp E, White GC, et al. The Malmö International Brother Study (MIBS): further support for genetic predisposition to inhibitor development in hemophilia patients. Haemophilia 2001;7:267-72
    • (2001) Haemophilia , vol.7 , pp. 267-272
    • Astermark, J.1    Berntorp, E.2    White, G.C.3
  • 31
    • 0029617930 scopus 로고
    • Haemophilia A: Mutation type determines risk of inhibitor formation
    • Schwaab R, Brackmann HH, Meyer C, et al. Haemophilia A: mutation type determines risk of inhibitor formation. Thromb Haemost 1995,74:1402-6
    • (1995) Thromb Haemost , vol.74 , pp. 1402-1406
    • Schwaab, R.1    Brackmann, H.H.2    Meyer, C.3
  • 32
    • 0031856834 scopus 로고    scopus 로고
    • The genetic basis of inhibitor development in haemophilia A
    • Tuddenham EG, McVey JH. The genetic basis of inhibitor development in haemophilia A. Haemophilia 1998;4:543-5
    • (1998) Haemophilia , vol.4 , pp. 543-545
    • Tuddenham, E.G.1    McVey, J.H.2
  • 33
    • 0033949469 scopus 로고    scopus 로고
    • Correlation between factor VIII genotype and inhibitor development in hemophilia A
    • Fakharzadeh SS, Kazazian HH Jr. Correlation between factor VIII genotype and inhibitor development in hemophilia A. Semin Thromb Hemost 2000;26:167-71
    • (2000) Semin Thromb Hemost , vol.26 , pp. 167-171
    • Fakharzadeh, S.S.1    Kazazian Jr., H.H.2
  • 34
    • 0842342601 scopus 로고    scopus 로고
    • Environmental and genetic factors influencing inhibitor development
    • Oldenburg J, Schroder J, Brackmann HH, et al. Environmental and genetic factors influencing inhibitor development. Semin Hematol 2004;41:82-8
    • (2004) Semin Hematol , vol.41 , pp. 82-88
    • Oldenburg, J.1    Schroder, J.2    Brackmann, H.H.3
  • 35
    • 0032742545 scopus 로고    scopus 로고
    • The role of genetics in inhibitor formation
    • Gill JC. The role of genetics in inhibitor formation. Thromb Haemost 1999;82:500-4
    • (1999) Thromb Haemost , vol.82 , pp. 500-504
    • Gill, J.C.1
  • 36
    • 33845239946 scopus 로고    scopus 로고
    • Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A
    • Astermark J, Oldenburg J, Carlson J, et al. Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A. Blood 2006;108:3739-45
    • (2006) Blood , vol.108 , pp. 3739-3745
    • Astermark, J.1    Oldenburg, J.2    Carlson, J.3
  • 37
    • 33645751563 scopus 로고    scopus 로고
    • Polymorphisms in the IL10 but not in the IL1beta and IL4 genes are associated with inhibitor development in patients with hemophilia A
    • Astermark J, Oldenburg J, Pavlova A, et al. Polymorphisms in the IL10 but not in the IL1beta and IL4 genes are associated with inhibitor development in patients with hemophilia A. Blood 2006;107:3167-72
    • (2006) Blood , vol.107 , pp. 3167-3172
    • Astermark, J.1    Oldenburg, J.2    Pavlova, A.3
  • 38
    • 33846420672 scopus 로고    scopus 로고
    • Polymorphisms in the CTLA-4 gene and inhibitor development in patients with severe hemophilia A
    • Astermark J, Wang X, Oldenburg J, et al. Polymorphisms in the CTLA-4 gene and inhibitor development in patients with severe hemophilia A. J Thromb Haemost 2007;5:263-5
    • (2007) J Thromb Haemost , vol.5 , pp. 263-265
    • Astermark, J.1    Wang, X.2    Oldenburg, J.3
  • 39
    • 0031598278 scopus 로고    scopus 로고
    • Inhibitors occur more frequently in African-American and Latino haemophiliacs
    • Aledort LM, DiMichele DM. Inhibitors occur more frequently in African-American and Latino haemophiliacs. Haemophilia 1998;4:68
    • (1998) Haemophilia , vol.4 , pp. 68
    • Aledort, L.M.1    DiMichele, D.M.2
  • 40
    • 5144221884 scopus 로고    scopus 로고
    • Human recombinant DNA-derived antihemophilic factor in the treatment of previously untreated patients with hemophilia A: Final report on a hallmark clinical investigation
    • Lusher J, Abildgaard C, Arkin S, et al. Human recombinant DNA-derived antihemophilic factor in the treatment of previously untreated patients with hemophilia A: final report on a hallmark clinical investigation. J Thromb Haemost 2004;2:574-83
    • (2004) J Thromb Haemost , vol.2 , pp. 574-583
    • Lusher, J.1    Abildgaard, C.2    Arkin, S.3
  • 41
    • 33646262886 scopus 로고    scopus 로고
    • Overview of inhibitors
    • Astermark J. Overview of inhibitors. Semin Hematol 2006;43:S3-7
    • (2006) Semin Hematol , vol.43
    • Astermark, J.1
  • 42
    • 16344393521 scopus 로고    scopus 로고
    • Prophylactic treatment effects on inhibitor risk: Experience in one centre
    • Morado M, Villar A, Jimenez Yuste V, et al. Prophylactic treatment effects on inhibitor risk: experience in one centre. Haemophilia 2005;11:79-83
    • (2005) Haemophilia , vol.11 , pp. 79-83
    • Morado, M.1    Villar, A.2    Jimenez Yuste, V.3
  • 43
    • 24944440876 scopus 로고    scopus 로고
    • Environmental risk factors for inhibitor development in children with haemophilia A: A case-control study
    • Santagostino E, Mancuso ME, Rocino A, et al. Environmental risk factors for inhibitor development in children with haemophilia A: a case-control study. Br J Haematol 2005;130:422-7
    • (2005) Br J Haematol , vol.130 , pp. 422-427
    • Santagostino, E.1    Mancuso, M.E.2    Rocino, A.3
  • 44
    • 34249690732 scopus 로고    scopus 로고
    • Treatment-related risk factors of inhibitor development in previously untreated patients with hemophilia A: The CANAL cohort study
    • Gouw SC, Van Der Bom JG, Marijke van den Berg H. Treatment-related risk factors of inhibitor development in previously untreated patients with hemophilia A: the CANAL cohort study. Blood 2007;109:4648-54
    • (2007) Blood , vol.109 , pp. 4648-4654
    • Gouw, S.C.1    Van Der Bom, J.G.2    Marijke van den Berg, H.3
  • 45
    • 4644334185 scopus 로고    scopus 로고
    • Prevention of bleeds in hemophilia patients with inhibitors: Emerging data and clinical direction
    • Leissinger CA. Prevention of bleeds in hemophilia patients with inhibitors: emerging data and clinical direction. Am J Hematol 2004;77:187-93
    • (2004) Am J Hematol , vol.77 , pp. 187-193
    • Leissinger, C.A.1
  • 46
    • 0034107545 scopus 로고    scopus 로고
    • Human coagulation factor FVIIa (recombinant) in the management of limb-threatening bleeds unresponsive to alternative therapies: Results from the NovoSeven emergency-use programme in patients with severe haemophilia or with acquired inhibitors
    • Arkin S, Blei F, Fetten J, et al. Human coagulation factor FVIIa (recombinant) in the management of limb-threatening bleeds unresponsive to alternative therapies: results from the NovoSeven emergency-use programme in patients with severe haemophilia or with acquired inhibitors. Blood Coagul Fibrinolysis 2000;11:255-9
    • (2000) Blood Coagul Fibrinolysis , vol.11 , pp. 255-259
    • Arkin, S.1    Blei, F.2    Fetten, J.3
  • 47
    • 0025180213 scopus 로고
    • Efficacy and safety of vapor-heated anti-inhibitor coagulant complex in hemophilia patients. FEIBA Study Group
    • Hilgartner M, Aledort L, Andes A, et al. Efficacy and safety of vapor-heated anti-inhibitor coagulant complex in hemophilia patients. FEIBA Study Group. Transfusion 1990;30:626-30
    • (1990) Transfusion , vol.30 , pp. 626-630
    • Hilgartner, M.1    Aledort, L.2    Andes, A.3
  • 48
    • 17144437423 scopus 로고    scopus 로고
    • Home treatment of mild to moderate bleeding episodes using recombinant factor VIIa (Novoseven) in haemophiliacs with inhibitors
    • Key NS, Aledort LM, Beardsley D, et al. Home treatment of mild to moderate bleeding episodes using recombinant factor VIIa (Novoseven) in haemophiliacs with inhibitors. Thromb Haemost 1998;80:912-8
    • (1998) Thromb Haemost , vol.80 , pp. 912-918
    • Key, N.S.1    Aledort, L.M.2    Beardsley, D.3
  • 49
    • 0030837755 scopus 로고    scopus 로고
    • Multicenter retrospective study on the utilization of FEIBA in France in patients with factor VIII and factor IX inhibitors. French FEIBA Study Group. Factor Eight Bypassing Activity
    • Negrier C, Goudemand J, Sultan Y, et al. Multicenter retrospective study on the utilization of FEIBA in France in patients with factor VIII and factor IX inhibitors. French FEIBA Study Group. Factor Eight Bypassing Activity. Thromb Haemost 1997;77:1113-9
    • (1997) Thromb Haemost , vol.77 , pp. 1113-1119
    • Negrier, C.1    Goudemand, J.2    Sultan, Y.3
  • 50
    • 0031743504 scopus 로고    scopus 로고
    • Prospective, randomised trial of two doses of rFVIIa (NovoSeven) in haemophilia patients with inhibitors undergoing surgery
    • Shapiro AD, Gilchrist GS, Hoots WK, et al. Prospective, randomised trial of two doses of rFVIIa (NovoSeven) in haemophilia patients with inhibitors undergoing surgery. Thromb Haemost 1998;80:773-8
    • (1998) Thromb Haemost , vol.80 , pp. 773-778
    • Shapiro, A.D.1    Gilchrist, G.S.2    Hoots, W.K.3
  • 51
    • 11044234837 scopus 로고    scopus 로고
    • Activated prothrombin complex concentrate (FEIBA) treatment during surgery in patients with inhibitors to FVIII/IX: The updated Norwegian experience
    • Tjonnfjord GE. Activated prothrombin complex concentrate (FEIBA) treatment during surgery in patients with inhibitors to FVIII/IX: the updated Norwegian experience. Haemophilia 2004;10(Suppl 2):41-5
    • (2004) Haemophilia , vol.10 , Issue.SUPPL. 2 , pp. 41-45
    • Tjonnfjord, G.E.1
  • 52
    • 33846185403 scopus 로고    scopus 로고
    • A randomized comparison of bypassing agents in hemophilia complicated by an inhibitor: The FEIBA NovoSeven Comparative (FENOC) Study
    • Astermark J, Donfield SM, DiMichele DM, et al. A randomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Comparative (FENOC) Study. Blood 2007;109:546-51
    • (2007) Blood , vol.109 , pp. 546-551
    • Astermark, J.1    Donfield, S.M.2    DiMichele, D.M.3
  • 53
    • 0033650677 scopus 로고    scopus 로고
    • Antibodies to factor VIII in hemophilia A patients
    • Brackmann HH, Schwaab R, Effenberger W, et al. Antibodies to factor VIII in hemophilia A patients. Vox Sang 2000;78(Suppl 2):187-90
    • (2000) Vox Sang , vol.78 , Issue.SUPPL. 2 , pp. 187-190
    • Brackmann, H.H.1    Schwaab, R.2    Effenberger, W.3
  • 54
    • 0032729980 scopus 로고    scopus 로고
    • Use of prothrombin complex concentrates and activated prothrombin complex concentrates as prophylactic therapy in haemophilia patients with inhibitors
    • Leissinger CA. Use of prothrombin complex concentrates and activated prothrombin complex concentrates as prophylactic therapy in haemophilia patients with inhibitors. Haemophilia 1999;5(suppl 3):25-32
    • (1999) Haemophilia , vol.5 , Issue.SUPPL. 3 , pp. 25-32
    • Leissinger, C.A.1
  • 55
    • 0033778140 scopus 로고    scopus 로고
    • Immune tolerance therapy for haemophilia
    • Ho AY, Height SE, Smith MP. Immune tolerance therapy for haemophilia. Drugs 2000;60:547-54
    • (2000) Drugs , vol.60 , pp. 547-554
    • Ho, A.Y.1    Height, S.E.2    Smith, M.P.3
  • 56
    • 0032836833 scopus 로고    scopus 로고
    • International immune tolerance registry, 1997 update
    • Mariani G, Kroner B. International immune tolerance registry, 1997 update. Vox Sang 1999;77(Suppl 1):25-7
    • (1999) Vox Sang , vol.77 , Issue.SUPPL. 1 , pp. 25-27
    • Mariani, G.1    Kroner, B.2
  • 57
    • 0036147943 scopus 로고    scopus 로고
    • The North American Immune Tolerance Registry: Practices, outcomes, outcome predictors
    • DiMichele DM, Kroner BL. The North American Immune Tolerance Registry: practices, outcomes, outcome predictors. Thromb Haemost 2002;87:52-7
    • (2002) Thromb Haemost , vol.87 , pp. 52-57
    • DiMichele, D.M.1    Kroner, B.L.2
  • 58
    • 0033678959 scopus 로고    scopus 로고
    • The German Registry of immune tolerance treatment in hemophilia: 1999 update
    • Lenk H. The German Registry of immune tolerance treatment in hemophilia: 1999 update. Haematologica 2000;85:45-7
    • (2000) Haematologica , vol.85 , pp. 45-47
    • Lenk, H.1
  • 59
    • 0035082871 scopus 로고    scopus 로고
    • Immune tolerance treatment in haemophilia patients with inhibitors: The Spanish Registry
    • Haya S, Lopez MF, Aznar JA, et al. Immune tolerance treatment in haemophilia patients with inhibitors: the Spanish Registry. Haemophilia 2001;7:154-9
    • (2001) Haemophilia , vol.7 , pp. 154-159
    • Haya, S.1    Lopez, M.F.2    Aznar, J.A.3
  • 60
    • 0034284456 scopus 로고    scopus 로고
    • Immune tolerance induction in hemophilia patients with inhibitors: Costly can be cheaper
    • Colowick AB, Bohn RL, Avorn J, et al. Immune tolerance induction in hemophilia patients with inhibitors: costly can be cheaper. Blood 2000;96:1698-702
    • (2000) Blood , vol.96 , pp. 1698-1702
    • Colowick, A.B.1    Bohn, R.L.2    Avorn, J.3
  • 61
    • 0017785868 scopus 로고
    • Massive factor-VIII infusion in haemophiliac with factor-VIII inhibitor, high responder
    • Brackmann HH, Gormsen J. Massive factor-VIII infusion in haemophiliac with factor-VIII inhibitor, high responder. Lancet 1977;2:933
    • (1977) Lancet , vol.2 , pp. 933
    • Brackmann, H.H.1    Gormsen, J.2
  • 62
    • 0030056318 scopus 로고    scopus 로고
    • Immune tolerance for the treatment of factor VIII inhibitors-twenty years' 'Bonn protocol'
    • Brackmann HH, Oldenburg J, Schwaab R. Immune tolerance for the treatment of factor VIII inhibitors-twenty years' 'Bonn protocol'. Vox Sang 1996;70(Suppl 1):30-5
    • (1996) Vox Sang , vol.70 , Issue.SUPPL. 1 , pp. 30-35
    • Brackmann, H.H.1    Oldenburg, J.2    Schwaab, R.3
  • 63
    • 0032883366 scopus 로고    scopus 로고
    • Induction of immune tolerance in haemophilia A inhibitor patients by the 'Bonn Protocol': Predictive parameter for therapy duration and outcome
    • Oldenburg J, Schwaab R, Brackmann HH. Induction of immune tolerance in haemophilia A inhibitor patients by the 'Bonn Protocol': predictive parameter for therapy duration and outcome. Vox Sang 1999;77(Suppl 1):49-54
    • (1999) Vox Sang , vol.77 , Issue.SUPPL. 1 , pp. 49-54
    • Oldenburg, J.1    Schwaab, R.2    Brackmann, H.H.3
  • 64
    • 0030022042 scopus 로고    scopus 로고
    • Low-dose immune tolerance therapy: The Van Creveld model
    • Mauser-Bunschoten EP, Roosendaal G, van den Berg HM. Low-dose immune tolerance therapy: the Van Creveld model. Vox Sang 1996;70(Suppl 1):66-7
    • (1996) Vox Sang , vol.70 , Issue.SUPPL. 1 , pp. 66-67
    • Mauser-Bunschoten, E.P.1    Roosendaal, G.2    van den Berg, H.M.3
  • 65
    • 0029133532 scopus 로고
    • Low-dose immune tolerance induction in hemophilia A patients with inhibitors
    • Mauser-Bunschoten EP, Nieuwenhuis HK, Roosendaal G, et al. Low-dose immune tolerance induction in hemophilia A patients with inhibitors. Blood 1995;86:983-8
    • (1995) Blood , vol.86 , pp. 983-988
    • Mauser-Bunschoten, E.P.1    Nieuwenhuis, H.K.2    Roosendaal, G.3
  • 66
    • 0033041458 scopus 로고    scopus 로고
    • Tolerance induction using the Malmö treatment model 1982-1995
    • Freiburghaus C, Berntorp E, Ekman M, et al. Tolerance induction using the Malmö treatment model 1982-1995. Haemophilia 1999;5:32-9
    • (1999) Haemophilia , vol.5 , pp. 32-39
    • Freiburghaus, C.1    Berntorp, E.2    Ekman, M.3
  • 67
    • 0023933922 scopus 로고
    • Induction of immune tolerance in patients with hemophilia and antibodies to factor VIII by combined treatment with intravenous IgG, cyclophosphamide, and factor VIII
    • Nilsson IM, Berntorp E, Zettervall O. Induction of immune tolerance in patients with hemophilia and antibodies to factor VIII by combined treatment with intravenous IgG, cyclophosphamide, and factor VIII. N Engl J Med 1988;318:947-50
    • (1988) N Engl J Med , vol.318 , pp. 947-950
    • Nilsson, I.M.1    Berntorp, E.2    Zettervall, O.3
  • 68
    • 0030044206 scopus 로고    scopus 로고
    • Immune tolerance and the immune modulation protocol
    • Berntorp E, Nilsson IM. Immune tolerance and the immune modulation protocol. Vox Sang 1996;70(Suppl 1):36-41
    • (1996) Vox Sang , vol.70 , Issue.SUPPL. 1 , pp. 36-41
    • Berntorp, E.1    Nilsson, I.M.2
  • 69
    • 0032949524 scopus 로고    scopus 로고
    • Immune tolerance therapy for haemophilia A patients with acquired factor VIII alloantibodies: Comprehensive analysis of experience at a single institution
    • Smith MP, Spence KJ, Waters EL, et al. Immune tolerance therapy for haemophilia A patients with acquired factor VIII alloantibodies: comprehensive analysis of experience at a single institution. Thromb Haemost 1999;81:35-8
    • (1999) Thromb Haemost , vol.81 , pp. 35-38
    • Smith, M.P.1    Spence, K.J.2    Waters, E.L.3
  • 70
    • 0035135212 scopus 로고    scopus 로고
    • Immune tolerance induction in haemophilia A patients with high-responding inhibitors to factor VIII: Experience at a single institution
    • Rocino A, Papa ML, Salerno E, et al. Immune tolerance induction in haemophilia A patients with high-responding inhibitors to factor VIII: experience at a single institution. Haemophilia 2001;7:33-8
    • (2001) Haemophilia , vol.7 , pp. 33-38
    • Rocino, A.1    Papa, M.L.2    Salerno, E.3
  • 71
    • 0026571955 scopus 로고
    • Induction of immune tolerance in patients with hemophilia A and inhibitors
    • Gruppo RA
    • Gruppo RA, Valdez LP, Stout RD. Induction of immune tolerance in patients with hemophilia A and inhibitors. Am J Pediatr Hematol Oncol 1992;14:82-7
    • (1992) Am J Pediatr Hematol Oncol , vol.14 , pp. 82-87
    • Valdez, L.P.1    Stout, R.D.2
  • 72
    • 40349096477 scopus 로고    scopus 로고
    • Low-dose immune tolerance induction for paediatric haemophilia patients with factor VIII inhibitors
    • Unuvar A, Kavakli K, Baytan B, et al. Low-dose immune tolerance induction for paediatric haemophilia patients with factor VIII inhibitors. Haemophilia 2008;14:315-22
    • (2008) Haemophilia , vol.14 , pp. 315-322
    • Unuvar, A.1    Kavakli, K.2    Baytan, B.3
  • 73
    • 0032882450 scopus 로고    scopus 로고
    • Comparison of the international immune tolerance registry and the North American immune tolerance registry
    • Kroner BL. Comparison of the international immune tolerance registry and the North American immune tolerance registry. Vox Sang 1999;77(Suppl 1):33-7
    • (1999) Vox Sang , vol.77 , Issue.SUPPL. 1 , pp. 33-37
    • Kroner, B.L.1
  • 74
    • 0033828382 scopus 로고    scopus 로고
    • Immune tolerance for haemophilia patients with inhibitors: Analysis of the western United States experience. The Tri-Regional Nursing Group
    • Damiano ML, Hutter JJ Jr. Immune tolerance for haemophilia patients with inhibitors: analysis of the western United States experience. The Tri-Regional Nursing Group Haemophilia 2000;6:526-32
    • (2000) Haemophilia , vol.6 , pp. 526-532
    • Damiano, M.L.1    Hutter Jr., J.J.2
  • 75
    • 0028244702 scopus 로고
    • Clinical course of factor VIII inhibitors developed after exposure to a pasteurised Dutch concentrate compared to classic inhibitors in hemophilia A
    • Mauser-Bunschoten EP, Rosendaal FR, Nieuwenhuis HK, et al. Clinical course of factor VIII inhibitors developed after exposure to a pasteurised Dutch concentrate compared to classic inhibitors in hemophilia A. Thromb Haemost 1994;71:703-6
    • (1994) Thromb Haemost , vol.71 , pp. 703-706
    • Mauser-Bunschoten, E.P.1    Rosendaal, F.R.2    Nieuwenhuis, H.K.3
  • 76
  • 77
    • 0032837450 scopus 로고    scopus 로고
    • Analysis of the North American Immune Tolerance Registry (NAITR) 1993-1997: Current practice implications. ISTH Factor VIII/IX Subcommittee Members
    • DiMichele DM, Kroner BL. Analysis of the North American Immune Tolerance Registry (NAITR) 1993-1997: current practice implications. ISTH Factor VIII/IX Subcommittee Members. Vox Sang 1999;77(Suppl 1):31-2
    • (1999) Vox Sang , vol.77 , Issue.SUPPL. 1 , pp. 31-32
    • DiMichele, D.M.1    Kroner, B.L.2
  • 78
    • 33748743730 scopus 로고    scopus 로고
    • The international immune tolerance study: A multicenter prospective randomized trial in progress
    • DiMichele DM, Hay CR. The international immune tolerance study: a multicenter prospective randomized trial in progress. J Thromb Haemost 2006;4:2271-3
    • (2006) J Thromb Haemost , vol.4 , pp. 2271-2273
    • DiMichele, D.M.1    Hay, C.R.2
  • 79
    • 1542374853 scopus 로고    scopus 로고
    • Secondary prophylaxis in severe haemophilia A: Results in preventing further joint damage [abstract 1923A]
    • Rocino A, Salerno E, Capasso F, et al. Secondary prophylaxis in severe haemophilia A: results in preventing further joint damage [abstract 1923A]. Thromb Haemost 1999;82:610
    • (1999) Thromb Haemost , vol.82 , pp. 610
    • Rocino, A.1    Salerno, E.2    Capasso, F.3
  • 80
    • 0034111357 scopus 로고    scopus 로고
    • Immune tolerance induction in the treatment of paediatric haemophilia A patients with factor VIII inhibitors
    • Unuvar A, Warrier I, Lusher JM. Immune tolerance induction in the treatment of paediatric haemophilia A patients with factor VIII inhibitors. Haemophilia 2000;6:150-7
    • (2000) Haemophilia , vol.6 , pp. 150-157
    • Unuvar, A.1    Warrier, I.2    Lusher, J.M.3
  • 81
    • 33645978414 scopus 로고    scopus 로고
    • Canadian multi-institutional survey of immune tolerance therapy (ITT): Experience with the use of recombinant factor VIII for ITT
    • Barnes C, Rivard GE, Poon MC, et al. Canadian multi-institutional survey of immune tolerance therapy (ITT): experience with the use of recombinant factor VIII for ITT. Haemophilia 2006;12:1-6
    • (2006) Haemophilia , vol.12 , pp. 1-6
    • Barnes, C.1    Rivard, G.E.2    Poon, M.C.3
  • 82
    • 33645959486 scopus 로고    scopus 로고
    • Immune tolerance induction with recombinant factor VIII in hemophilia A patients with high responding inhibitors
    • Rocino A, Santagostino E, Mancuso ME, et al. Immune tolerance induction with recombinant factor VIII in hemophilia A patients with high responding inhibitors. Haematologica 2006;91:558-61
    • (2006) Haematologica , vol.91 , pp. 558-561
    • Rocino, A.1    Santagostino, E.2    Mancuso, M.E.3
  • 83
    • 57649172469 scopus 로고    scopus 로고
    • Kreuz W, Ettingshausen CE, Auerswald G, et al. Epidemiology of inhibitors and current treatment strategies. Haematologica 2003;88:EREP04
    • Kreuz W, Ettingshausen CE, Auerswald G, et al. Epidemiology of inhibitors and current treatment strategies. Haematologica 2003;88:EREP04
  • 84
    • 19944394681 scopus 로고    scopus 로고
    • Immune tolerance induction in haemophilia A patients with inhibitors: The choice of concentrate affecting success
    • Kreuz W, Escuriola-Ettingshausen C, Auerswald G. Immune tolerance induction in haemophilia A patients with inhibitors: the choice of concentrate affecting success. Haematological 2001;86(suppl 4):16-20
    • (2001) Haematological , vol.86 , Issue.SUPPL. 4 , pp. 16-20
    • Kreuz, W.1    Escuriola-Ettingshausen, C.2    Auerswald, G.3
  • 85
    • 57649185927 scopus 로고    scopus 로고
    • Auerswald G, Spranger T, Brackmann HH. The role of plasma-derived factor VIII/von Willebrand factor concentrates in the treatment of hemophilia A patients [abstract]. Haematological 2003;88:EREP05
    • Auerswald G, Spranger T, Brackmann HH. The role of plasma-derived factor VIII/von Willebrand factor concentrates in the treatment of hemophilia A patients [abstract]. Haematological 2003;88:EREP05
  • 86
    • 34447287337 scopus 로고    scopus 로고
    • Immune tolerance induction with a high purity von Willebrand factor/VIII complex concentrate in haemophilia A patients with inhibitors at high risk of a poor response
    • Gringeri A, Musso R, Mazzucconi MG, et al. Immune tolerance induction with a high purity von Willebrand factor/VIII complex concentrate in haemophilia A patients with inhibitors at high risk of a poor response. Haemophilial 2007;13:373-9
    • (2007) Haemophilial , vol.13 , pp. 373-379
    • Gringeri, A.1    Musso, R.2    Mazzucconi, M.G.3
  • 87
    • 25444521967 scopus 로고    scopus 로고
    • Immune tolerance induction with highly purified plasma-derived factor VIII containing von Willebrand factor in hemophilia A patients with high-responding inhibitors
    • Orsini F, Rothschild C, Beurrier P, et al. Immune tolerance induction with highly purified plasma-derived factor VIII containing von Willebrand factor in hemophilia A patients with high-responding inhibitors. Haematological 2005;90:1288-90
    • (2005) Haematological , vol.90 , pp. 1288-1290
    • Orsini, F.1    Rothschild, C.2    Beurrier, P.3
  • 88
    • 0036332175 scopus 로고    scopus 로고
    • Von Willebrand factor modulates factor VIII immunogenicity: Comparative study of different factor VIII concentrates in a haemophilia A mouse model
    • Behrmann M, Pasi J, Saint-Remy JM, et al. Von Willebrand factor modulates factor VIII immunogenicity: comparative study of different factor VIII concentrates in a haemophilia A mouse model. Thromb Haemost 2002;88:221-9
    • (2002) Thromb Haemost , vol.88 , pp. 221-229
    • Behrmann, M.1    Pasi, J.2    Saint-Remy, J.M.3
  • 89
    • 0035133958 scopus 로고    scopus 로고
    • Immune tolerance induction: Recombinant vs. human-derived product
    • Berntorp E. Immune tolerance induction: recombinant vs. human-derived product. Haemophilial 2001;7:109-13
    • (2001) Haemophilial , vol.7 , pp. 109-113
    • Berntorp, E.1
  • 90
    • 19944390186 scopus 로고    scopus 로고
    • Role of von Willebrand factor in immune tolerance induction
    • Ettingshausen CE, Kreuz W. Role of von Willebrand factor in immune tolerance induction. Blood Coagul Fibrinolysis 2005;16(Suppl 1):S27-31
    • (2005) Blood Coagul Fibrinolysis , vol.16 , Issue.SUPPL. 1
    • Ettingshausen, C.E.1    Kreuz, W.2
  • 91
    • 0034917040 scopus 로고    scopus 로고
    • von Willebrand factor in factor VIII concentrates protects against neutralization by factor VIII antibodies of haemophilia A patients
    • Kallas A, Talpsep T. von Willebrand factor in factor VIII concentrates protects against neutralization by factor VIII antibodies of haemophilia A patients. Haemophilia 2001;7:375-80
    • (2001) Haemophilia , vol.7 , pp. 375-380
    • Kallas, A.1    Talpsep, T.2
  • 92
    • 0029910889 scopus 로고    scopus 로고
    • Factor VIII inhibitor antibodies with C2 domain specificity are less inhibitory to factor VIII complexed with von Willebrand factor
    • Suzuki T, Arai M, Amano K, et al. Factor VIII inhibitor antibodies with C2 domain specificity are less inhibitory to factor VIII complexed with von Willebrand factor. Thromb Haemost 1996;76:749-54
    • (1996) Thromb Haemost , vol.76 , pp. 749-754
    • Suzuki, T.1    Arai, M.2    Amano, K.3
  • 93
    • 0034913420 scopus 로고    scopus 로고
    • Influence of von Willebrand factor on the reactivity of human factor VIII inhibitors with factor VIII
    • Gensana M, Altisent C, Aznar JA, et al. Influence of von Willebrand factor on the reactivity of human factor VIII inhibitors with factor VIII. Haemophilia 2001;7:369-74
    • (2001) Haemophilia , vol.7 , pp. 369-374
    • Gensana, M.1    Altisent, C.2    Aznar, J.A.3
  • 94
    • 37149039173 scopus 로고    scopus 로고
    • VWF/FVIII complex and the management of patient with inhibitors: From laboratory to clinical practice
    • Berntorp E. VWF/FVIII complex and the management of patient with inhibitors: from laboratory to clinical practice. Haemophilia 2007;13(Suppl 5):69-72
    • (2007) Haemophilia , vol.13 , Issue.SUPPL. 5 , pp. 69-72
    • Berntorp, E.1
  • 95
    • 33750974213 scopus 로고    scopus 로고
    • Immune tolerance: Critical issues of factor dose, purity and treatment complications
    • DiMichele DM. Immune tolerance: critical issues of factor dose, purity and treatment complications. Haemophilia 2006;12(Suppl 6):81-6
    • (2006) Haemophilia , vol.12 , Issue.SUPPL. 6 , pp. 81-86
    • DiMichele, D.M.1
  • 96
    • 0242608362 scopus 로고    scopus 로고
    • Immunoadsorption may provide a cost-effective approach to management of patients with inhibitors to FVIII
    • Freedman J, Rand ML, Russell O, et al. Immunoadsorption may provide a cost-effective approach to management of patients with inhibitors to FVIII. Transfusion 2003;43:1508-13
    • (2003) Transfusion , vol.43 , pp. 1508-1513
    • Freedman, J.1    Rand, M.L.2    Russell, O.3
  • 97
    • 18144440424 scopus 로고    scopus 로고
    • Extracorporeal immunoadsorption for the treatment of haemophilic patients with inhibitors to factor VIII or IX
    • Knobl P, Derfler K. Extracorporeal immunoadsorption for the treatment of haemophilic patients with inhibitors to factor VIII or IX. Vox Sang 1999;77(Suppl 1):57-64
    • (1999) Vox Sang , vol.77 , Issue.SUPPL. 1 , pp. 57-64
    • Knobl, P.1    Derfler, K.2
  • 98
    • 0348218225 scopus 로고    scopus 로고
    • Immunoadsorption for coagulation factor inhibitors: A retrospective critical appraisal of 10 consecutive cases from a single institution
    • Rivard GE, St Louis J, Lacroix S, et al. Immunoadsorption for coagulation factor inhibitors: a retrospective critical appraisal of 10 consecutive cases from a single institution. Haemophilia 2003;9:711-6
    • (2003) Haemophilia , vol.9 , pp. 711-716
    • Rivard, G.E.1    St Louis, J.2    Lacroix, S.3
  • 99
    • 10844292763 scopus 로고    scopus 로고
    • Immunosuppressive drugs for kidney transplantation
    • Halloran PF. Immunosuppressive drugs for kidney transplantation. N Engl J Med 2004;351:2715-29
    • (2004) N Engl J Med , vol.351 , pp. 2715-2729
    • Halloran, P.F.1
  • 100
    • 33845771297 scopus 로고    scopus 로고
    • Cyclosporin A can achieve immune tolerance in a patient with severe haemophilia B and refractory inhibitors
    • Cross DC, Van Der Berg HM. Cyclosporin A can achieve immune tolerance in a patient with severe haemophilia B and refractory inhibitors. Haemophilia 2007;13:111-4
    • (2007) Haemophilia , vol.13 , pp. 111-114
    • Cross, D.C.1    Van Der Berg, H.M.2
  • 101
    • 28444457696 scopus 로고    scopus 로고
    • Rituximab-induced long-term remission in patients with refractory acquired hemophilia
    • Abdallah A, Coghlan DW, Duncan EM, et al. Rituximab-induced long-term remission in patients with refractory acquired hemophilia. J Thromb Haemost 2005;3:2589-90
    • (2005) J Thromb Haemost , vol.3 , pp. 2589-2590
    • Abdallah, A.1    Coghlan, D.W.2    Duncan, E.M.3
  • 102
    • 33646013613 scopus 로고    scopus 로고
    • Rituximab in the treatment of high responding inhibitors in severe haemophilia A
    • Moschovi M, Aronis S, Trimis G, et al. Rituximab in the treatment of high responding inhibitors in severe haemophilia A. Haemophilia 2006;12:95-9
    • (2006) Haemophilia , vol.12 , pp. 95-99
    • Moschovi, M.1    Aronis, S.2    Trimis, G.3
  • 103
    • 11144327961 scopus 로고    scopus 로고
    • Successful treatment of an autoantibody in congenital hemophilia with rituximab [abstract 3915]
    • Escobar M, Kempton C, Ma A. Successful treatment of an autoantibody in congenital hemophilia with rituximab [abstract 3915]. Blood 2002;100:109b
    • (2002) Blood , vol.100
    • Escobar, M.1    Kempton, C.2    Ma, A.3
  • 104
    • 33645981947 scopus 로고    scopus 로고
    • Rituximab for congenital haemophiliacs with inhibitors: A Canadian experience
    • Carcao M, St Louis J, Poon MC, et al. Rituximab for congenital haemophiliacs with inhibitors: a Canadian experience. Haemophilia 2006;12:7-18
    • (2006) Haemophilia , vol.12 , pp. 7-18
    • Carcao, M.1    St Louis, J.2    Poon, M.C.3
  • 105
    • 33751006071 scopus 로고    scopus 로고
    • Successful treatment of a high titre factor VIII inhibitor with rituximab alone [abstract 631]
    • Dunkley S, Lindeman R. Successful treatment of a high titre factor VIII inhibitor with rituximab alone [abstract 631]. J Thromb Haemost 2005;3(suppl 2)
    • (2005) J Thromb Haemost , vol.3 , Issue.SUPPL. 2
    • Dunkley, S.1    Lindeman, R.2
  • 106
    • 33645075447 scopus 로고    scopus 로고
    • The use of rituximab in two children with allo-antibodies towards factor VIII
    • Curry N, Stanworth S, Keeling D. The use of rituximab in two children with allo-antibodies towards factor VIII. Br J Haematol 2006;133:214-6
    • (2006) Br J Haematol , vol.133 , pp. 214-216
    • Curry, N.1    Stanworth, S.2    Keeling, D.3
  • 107
    • 33645974397 scopus 로고    scopus 로고
    • Use of rituximab as an alternative strategy for the management of difficult high titre inhibitors in children with hemophilia A [abstract 30]
    • Curtin J, Misra A, Teo J, et al. Use of rituximab as an alternative strategy for the management of difficult high titre inhibitors in children with hemophilia A [abstract 30]. Haemophilia 2004;10(Suppl 3):57
    • (2004) Haemophilia , vol.10 , Issue.SUPPL. 3 , pp. 57
    • Curtin, J.1    Misra, A.2    Teo, J.3
  • 108
    • 33646005964 scopus 로고    scopus 로고
    • Rituximab as a new inhibitor elimination agent in high-titer inhibitor patients-a long-term follow-up
    • Linde R, Escuriola-Ettinghausen C, Konigs C, et al. Rituximab as a new inhibitor elimination agent in high-titer inhibitor patients-a long-term follow-up. Haemophilia 2004;10(suppl 3):60
    • (2004) Haemophilia , vol.10 , Issue.SUPPL. 3 , pp. 60
    • Linde, R.1    Escuriola-Ettinghausen, C.2    Konigs, C.3
  • 109
    • 33645548972 scopus 로고    scopus 로고
    • Successful suppression using Rituximab of a factor VIII inhibitor in a boy with severe congenital haemophilia: An example of a significant decrease of treatment costs
    • Mateo J, Badell I, Forner R, et al. Successful suppression using Rituximab of a factor VIII inhibitor in a boy with severe congenital haemophilia: an example of a significant decrease of treatment costs. Thromb Haemost 2006;95:386-7
    • (2006) Thromb Haemost , vol.95 , pp. 386-387
    • Mateo, J.1    Badell, I.2    Forner, R.3
  • 110
    • 2442472195 scopus 로고    scopus 로고
    • Rituximab in the treatment of alloimmune factor VIII and IX antibodies in two children with severe haemophilia
    • Mathias M, Khair K, Hann I, et al. Rituximab in the treatment of alloimmune factor VIII and IX antibodies in two children with severe haemophilia. Br J Haematol 2004;125:366-8
    • (2004) Br J Haematol , vol.125 , pp. 366-368
    • Mathias, M.1    Khair, K.2    Hann, I.3
  • 111
    • 33645977626 scopus 로고    scopus 로고
    • Improved response to immune tolerance therapy for factor VIII inhibitor after rituximab therapy [abstract 3890]
    • Medeiros BC, Geraghty S, Stabler SP. Improved response to immune tolerance therapy for factor VIII inhibitor after rituximab therapy [abstract 3890]. Blood 2002;100:103b
    • (2002) Blood , vol.100
    • Medeiros, B.C.1    Geraghty, S.2    Stabler, S.P.3
  • 112
    • 33646007134 scopus 로고    scopus 로고
    • Rituximab treatment of FVIII inhibitors in congenital hemophilia A (cHA) [abstract P652]
    • Pruthi RK, Schmidt KA, Slaby JA, et al. Rituximab treatment of FVIII inhibitors in congenital hemophilia A (cHA) [abstract P652]. J Thromb Haemost 2005;3(Suppl 2)
    • (2005) J Thromb Haemost , vol.3 , Issue.SUPPL. 2
    • Pruthi, R.K.1    Schmidt, K.A.2    Slaby, J.A.3
  • 113
    • 0035170866 scopus 로고    scopus 로고
    • Immune tolerance in hemophilia with factor VIII inhibitors: Predictors of success
    • Mariani G, Kroner B. Immune tolerance in hemophilia with factor VIII inhibitors: predictors of success. Haematological 2001;86:1186-93
    • (2001) Haematological , vol.86 , pp. 1186-1193
    • Mariani, G.1    Kroner, B.2


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