The genetic basis of inhibitor development in haemophilia A

Haemophilia

Volumn 4, Issue 4, 1998, Pages 543-545

  Tuddenham, E G D ^a   Mcvey, J H ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Antibodies; Factor VIII; Haemophilia A; Inhibitor; Mutation

Indexed keywords

BLOOD CLOTTING FACTOR 8 INHIBITOR;

ANTIBODY RESPONSE; CONFERENCE PAPER; DISEASE SEVERITY; ENVIRONMENTAL FACTOR; GENE MUTATION; GENETICS; GENOTYPE; HEMOPHILIA A; HUMAN; IMMUNE RESPONSE; PRIORITY JOURNAL; SUBSTITUTION THERAPY;

EID: 0031856834     PISSN: 13518216     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2516.1998.440543.x     Document Type: Conference Paper

References (7)

1. Yee TT, Williams MD, Hill FGH, Lee CA, Pasi KJ. Absence of inhibitors in previously untreated patients with severe haemophilia A after exposure to a single intermediate purity factor VIII product. Thromb Haemost 1997; 78: 1027-9.
2. Schwaab R, Brackmann HH, Seehafer J, Kirchgesser M, Olek K, Tuddenham EGD, Oldenburg J. Haemophilia A: mutation type determines risk of inhibitor formation. Thromb Haemost 1995; 74(6): 1402-6.
3. Young M, Inaba H, Hoyer LW, Higuchi M, Kazazian HH Jr, Antonarakis SE. Partial correction of a severe molecular defect in hemophilia A, because of errors during expression of the factor VIII gene. Am J Hum Genet 1997; 60(3): 565-73.
4. Aoufouchi S, Yelamos J, Milstein C. Nonsense mutations inhibit RNA splicing in a cell-free system; recognition of mutant codon is independent of protein synthesis. Cell 1996; 85(3): 415-22.
5. Naylor JA, Green PM, Rizza CR, Giannelli F. Analysis of factor VIII mRNA reveals defects in everyone of 28 haemophilia A patients. Hum Mol Genet 1993; 2(1): 11-7.
6. Oldenburg J, Picard J, Schwaab R, Brackman HH, Tuddenham EGD, Simpson E. HLA genotype of patients with severe haemophilia A due to intron 22 inversion with and without inhibitors of factor VIII. Thromb Haemost 1997; 77(2): 238-42.
7. Hay CRM, Ollier W, Pepper L, Cumming A, Keeney S, Goodeve AC et al. HLA class II profile: A weak determinant of factor VIII inhibitor development in severe haemophilia A. Thromb Haemost 1997; 77(2): 234-7.