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Volumn 77, Issue 2, 2004, Pages 187-193

Prevention of bleeds in hemophilia patients with inhibitors: Emerging data and clinical direction

Author keywords

Hemophilia A; Immune tolerance therapy; Inhibitors; Prophylaxis; Prothrombin complex concentrates

Indexed keywords

ACTIVATED PROTHROMBIN COMPLEX; BLOOD CLOTTING FACTOR 8 INHIBITOR; FEIBA VH; PROTHROMBIN COMPLEX; RECOMBINANT BLOOD CLOTTING FACTOR 7A;

EID: 4644334185     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.20162     Document Type: Short Survey
Times cited : (85)

References (51)
  • 1
    • 0032787813 scopus 로고    scopus 로고
    • Incidence of inhibitors in hemophilia A patients: A review of recent studies of recombinant and plasma-derived factor VIII concentrates
    • Scharrer I, Bray G, Netzling O. Incidence of inhibitors in hemophilia A patients: a review of recent studies of recombinant and plasma-derived factor VIII concentrates. Haemophilia 1999;5:145-154.
    • (1999) Haemophilia , vol.5 , pp. 145-154
    • Scharrer, I.1    Bray, G.2    Netzling, O.3
  • 2
    • 0033678089 scopus 로고    scopus 로고
    • Factor VIII inhibitors with recombinant products: Prospective clinical trials
    • Lusher J. Factor VIII inhibitors with recombinant products: prospective clinical trials. Haemotologica 2000;85(Suppl 10):2-6.
    • (2000) Haemotologica , vol.85 , Issue.SUPPL. 10 , pp. 2-6
    • Lusher, J.1
  • 3
    • 0038383605 scopus 로고    scopus 로고
    • The epidemiology of inhibitors in hemophilia A: A systematic review
    • Wight J, Paisley S. The epidemiology of inhibitors in hemophilia A: a systematic review. Haemophilia 2003;9:418-435.
    • (2003) Haemophilia , vol.9 , pp. 418-435
    • Wight, J.1    Paisley, S.2
  • 4
    • 0034284456 scopus 로고    scopus 로고
    • Immune tolerance induction in hemophilia patients with inhibitors: Costly can be cheaper
    • Colowick AB, Bohn RL, Avom J, Ewenstein BM. Immune tolerance induction in hemophilia patients with inhibitors: costly can be cheaper. Blood 2000;96:1698-1702.
    • (2000) Blood , vol.96 , pp. 1698-1702
    • Colowick, A.B.1    Bohn, R.L.2    Avom, J.3    Ewenstein, B.M.4
  • 5
    • 0028838605 scopus 로고
    • Mortality in patients with hemophilia. Changes in a Dutch population from 1986 to 1992 and 1973 to 1986
    • Triemstra M, Rosendaal FR, Smit C, Van der Ploeg HM, Briet E. Mortality in patients with hemophilia. Changes in a Dutch population from 1986 to 1992 and 1973 to 1986. Ann Intern Med 1995;123:823-827.
    • (1995) Ann Intern Med , vol.123 , pp. 823-827
    • Triemstra, M.1    Rosendaal, F.R.2    Smit, C.3    Van Der Ploeg, H.M.4    Briet, E.5
  • 6
    • 79960971174 scopus 로고    scopus 로고
    • Inhibitor prevalence and association with morbidity in severe hemophilia A patients
    • Leissinger C, Wulff K, Abdou A. Inhibitor prevalence and association with morbidity in severe hemophilia A patients. Blood 2001;98:535a.
    • (2001) Blood , vol.98
    • Leissinger, C.1    Wulff, K.2    Abdou, A.3
  • 7
    • 0033710529 scopus 로고    scopus 로고
    • Risk factors for inhibitor development in hemophilia A
    • Oldenburg J, Brackmann HH, Schwaab. Risk factors for inhibitor development in hemophilia A. Haematologica 2000;85(Suppl 10): 7-13.
    • (2000) Haematologica , vol.85 , Issue.SUPPL. 10 , pp. 7-13
    • Oldenburg, J.1    Brackmann, H.H.2    Schwaab3
  • 8
    • 0029617930 scopus 로고
    • Haemophilia A: Mutation type determines risk of inhibitor formation
    • Schwaab R, Brackmann HH, Meyer C, et al. Haemophilia A: mutation type determines risk of inhibitor formation. Thromb Haemost 1995;74:1402-1406.
    • (1995) Thromb Haemost , vol.74 , pp. 1402-1406
    • Schwaab, R.1    Brackmann, H.H.2    Meyer, C.3
  • 9
    • 0031057651 scopus 로고    scopus 로고
    • HLA class II profile: A weak determinant of factor VIII inhibitor development in severe haemophilia A
    • UKHCDO Inhibitor Working Party
    • Hay CR, Ollier W, Pepper L, et al. HLA class II profile: a weak determinant of factor VIII inhibitor development in severe haemophilia A. UKHCDO Inhibitor Working Party. Thromb Haemost 1997;77:234-237.
    • (1997) Thromb Haemost , vol.77 , pp. 234-237
    • Hay, C.R.1    Ollier, W.2    Pepper, L.3
  • 10
    • 0031045680 scopus 로고    scopus 로고
    • HLA genotype of patients with severe hemophilia A due to intron 22 inversions with and without inhibitors to factor VIII
    • Oldenburg J, Picard J, Schwaab R, Brackmann HH, Tuddenham EGD, Simpson E. HLA genotype of patients with severe hemophilia A due to intron 22 inversions with and without inhibitors to factor VIII. Thromb Haemost 1997;77:238-242.
    • (1997) Thromb Haemost , vol.77 , pp. 238-242
    • Oldenburg, J.1    Picard, J.2    Schwaab, R.3    Brackmann, H.H.4    Tuddenham, E.G.D.5    Simpson, E.6
  • 12
    • 0034994489 scopus 로고    scopus 로고
    • Incidence of factor VIII inhibitors in severe hemophilia: The importance of patient age
    • Lorenzo J, Lopez A, Altisent C, Aznar J. Incidence of factor VIII inhibitors in severe hemophilia: the importance of patient age. Br J Haematol 2001;113:600-603.
    • (2001) Br J Haematol , vol.113 , pp. 600-603
    • Lorenzo, J.1    Lopez, A.2    Altisent, C.3    Aznar, J.4
  • 13
    • 0031598278 scopus 로고    scopus 로고
    • Inhibitors occur more frequently in African-American and Latino haemophiliacs
    • Aledort LM, DiMichele DM. Inhibitors occur more frequently in African-American and Latino haemophiliacs. Haemophilia 1998;1:68.
    • (1998) Haemophilia , vol.1 , pp. 68
    • Aledort, L.M.1    DiMichele, D.M.2
  • 14
    • 4644343680 scopus 로고    scopus 로고
    • Inhibitors in African Americans with severe hemophilia A
    • Kruse-Jarres R, Wulff K, Leissinger C. Inhibitors in African Americans with severe hemophilia A. Blood 2003;102:799a.
    • (2003) Blood , vol.102
    • Kruse-Jarres, R.1    Wulff, K.2    Leissinger, C.3
  • 15
    • 0031925855 scopus 로고    scopus 로고
    • How do some hemophiliacs develop inhibitors?
    • Vermylen J. How do some hemophiliacs develop inhibitors? Haemophilia 1998;4:538-542.
    • (1998) Haemophilia , vol.4 , pp. 538-542
    • Vermylen, J.1
  • 16
    • 0031048881 scopus 로고    scopus 로고
    • Factor VIII inhibitors in previously treated hemophilia A patients with a double virus inactivated plasma derived factor VIII concentrate
    • Peerlinck K, Arnout J, Di Giambattista M, et al. Factor VIII inhibitors in previously treated hemophilia A patients with a double virus inactivated plasma derived factor VIII concentrate. Thromb Haemost 1997;77:80-86.
    • (1997) Thromb Haemost , vol.77 , pp. 80-86
    • Peerlinck, K.1    Arnout, J.2    Di Giambattista, M.3
  • 17
    • 0027392864 scopus 로고
    • A higher than expected incidence of factor VIII inhibitors in multi-transfused hemophilia A patients treated with an intermediate purity pasteurized factor VIII concentrate
    • Peerlinck K, Arnout J, Gilles JG, Saint-Remy J-M, Vermylen J. A higher than expected incidence of factor VIII inhibitors in multi-transfused hemophilia A patients treated with an intermediate purity pasteurized factor VIII concentrate. Thromb Haemost 1993;69:115-118.
    • (1993) Thromb Haemost , vol.69 , pp. 115-118
    • Peerlinck, K.1    Arnout, J.2    Gilles, J.G.3    Saint-Remy, J.-M.4    Vermylen, J.5
  • 18
    • 0016853978 scopus 로고
    • Proceedings: A more uniform measurement of factor VIII inhibitors
    • Kasper CK, Aledort L, Aronson D, et al. Proceedings: a more uniform measurement of factor VIII inhibitors. Thromb Diath Haemorrh 1975;34:612.
    • (1975) Thromb Diath Haemorrh , vol.34 , pp. 612
    • Kasper, C.K.1    Aledort, L.2    Aronson, D.3
  • 19
    • 0023614120 scopus 로고
    • Factor VIII inhibitors. Etiology, characterization, natural history, and management
    • Lusher JM. Factor VIII inhibitors. Etiology, characterization, natural history, and management. Ann NY Acad Sci 1987;509:89-102.
    • (1987) Ann NY Acad Sci , vol.509 , pp. 89-102
    • Lusher, J.M.1
  • 20
    • 0033778140 scopus 로고    scopus 로고
    • Immune tolerance therapy for haemophilia
    • Ho AY, Height SE, Smith MP. Immune tolerance therapy for haemophilia. Drugs 2000;60:547-554.
    • (2000) Drugs , vol.60 , pp. 547-554
    • Ho, A.Y.1    Height, S.E.2    Smith, M.P.3
  • 21
    • 0031701034 scopus 로고    scopus 로고
    • Immune tolerance induction: A role for recombinant activated factor VII (rFVIIa)?
    • Brackmann HH, Effenberger W, Hess, L, Schwaab R, Oldenburg J. Immune tolerance induction: a role for recombinant activated factor VII (rFVIIa)? Eur J Haematol 1998;61(Suppl 63):18-23.
    • (1998) Eur J Haematol , vol.61 , Issue.SUPPL. 63 , pp. 18-23
    • Brackmann, H.H.1    Effenberger, W.2    Hess, L.3    Schwaab, R.4    Oldenburg, J.5
  • 22
    • 9044239679 scopus 로고    scopus 로고
    • Safety profile of porcine factor VIII and its use as hospital and home-therapy for patients with haemophilia A and inhibitors: The results of an international survey
    • Hay CR, Lozier JN, Lee CA, et al. Safety profile of porcine factor VIII and its use as hospital and home-therapy for patients with haemophilia A and inhibitors: the results of an international survey. Thromb Haemost 1996;75:25-29.
    • (1996) Thromb Haemost , vol.75 , pp. 25-29
    • Hay, C.R.1    Lozier, J.N.2    Lee, C.A.3
  • 23
    • 0032837605 scopus 로고    scopus 로고
    • Factor Xa and prothrombin: Mechanism of action of FEIBA
    • Turecek P, Varadi K, Gritsch H, et al. Factor Xa and prothrombin: mechanism of action of FEIBA. Vox Sang 1999;77(Suppl 1): 72-79.
    • (1999) Vox Sang , vol.77 , Issue.SUPPL. 1 , pp. 72-79
    • Turecek, P.1    Varadi, K.2    Gritsch, H.3
  • 24
    • 0019426632 scopus 로고
    • The effect of activated prothrombin-complex concentrate (FEIBA) on joint and muscle bleeding in patients with hemophilia A and antibodies to Factor VIII. A double-blind clinical trial
    • Sjamsoedin LJ, Heijnen L, Mauser-Bunshoten EP, et al. The effect of activated prothrombin-complex concentrate (FEIBA) on joint and muscle bleeding in patients with hemophilia A and antibodies to Factor VIII. A double-blind clinical trial. N Engl J Med 1981;305:717-721.
    • (1981) N Engl J Med , vol.305 , pp. 717-721
    • Sjamsoedin, L.J.1    Heijnen, L.2    Mauser-Bunshoten, E.P.3
  • 25
    • 0030837755 scopus 로고    scopus 로고
    • Multicenter retrospective study on the utilization of FEIBA in France in patients with Factor VIII and Factor IX inhibitors
    • French FEIBA Study Group. Factor Eight Bypassing Activity
    • Negrier C, Goudemand J, Sultan Y, Bertrand M, Rothschild C, Lauroua P. Multicenter retrospective study on the utilization of FEIBA in France in patients with Factor VIII and Factor IX inhibitors. French FEIBA Study Group. Factor Eight Bypassing Activity. Thromb Haemost 1997;77:1113-1119.
    • (1997) Thromb Haemost , vol.77 , pp. 1113-1119
    • Negrier, C.1    Goudemand, J.2    Sultan, Y.3    Bertrand, M.4    Rothschild, C.5    Lauroua, P.6
  • 26
    • 0032729980 scopus 로고    scopus 로고
    • Use of prothrombin complex concentrates and activated prothrombin complex concentrates as prophylactic therapy in haemophilia patients with inhibitors
    • Leissinger CA. Use of prothrombin complex concentrates and activated prothrombin complex concentrates as prophylactic therapy in haemophilia patients with inhibitors. Haemophilia 1999;5(Suppl 3):25-32.
    • (1999) Haemophilia , vol.5 , Issue.SUPPL. 3 , pp. 25-32
    • Leissinger, C.A.1
  • 27
    • 0036489638 scopus 로고    scopus 로고
    • Safety of factor VIII inhibitor bypass activity (FEIBA): 10-year compilation of thrombotic adverse events
    • Ehrlich HJ, Henzl MJ, Gomperts ED. Safety of factor VIII inhibitor bypass activity (FEIBA): 10-year compilation of thrombotic adverse events. Haemophilia 2002;8:83-90.
    • (2002) Haemophilia , vol.8 , pp. 83-90
    • Ehrlich, H.J.1    Henzl, M.J.2    Gomperts, E.D.3
  • 28
    • 0032705135 scopus 로고    scopus 로고
    • Recombinant factor VIIa versus aPCCs in haemophiliacs with inhibitors: Treatment and cost considerations
    • Teitel JM. Recombinant factor VIIa versus aPCCs in haemophiliacs with inhibitors: treatment and cost considerations. Haemophilia 1999;5(Suppl 3):43-49.
    • (1999) Haemophilia , vol.5 , Issue.SUPPL. 3 , pp. 43-49
    • Teitel, J.M.1
  • 29
    • 0021358722 scopus 로고
    • Incidence of immune responses following 102 infusions of autoplex in 18 hemophilic patients with antibody to factor VIII
    • Laurian Y, Girma JP, Lambert T, Meyer D, Larrieu MJ. Incidence of immune responses following 102 infusions of autoplex in 18 hemophilic patients with antibody to factor VIII. Blood 1984;63:457-462.
    • (1984) Blood , vol.63 , pp. 457-462
    • Laurian, Y.1    Girma, J.P.2    Lambert, T.3    Meyer, D.4    Larrieu, M.J.5
  • 30
    • 0033935277 scopus 로고    scopus 로고
    • Inhibitor antibodies to factor VIII and factor IX: Management
    • Lusher JM. Inhibitor antibodies to factor VIII and factor IX: management. Semin Thromb Hemost 2000;26:179-188.
    • (2000) Semin Thromb Hemost , vol.26 , pp. 179-188
    • Lusher, J.M.1
  • 31
    • 0038721766 scopus 로고    scopus 로고
    • Economic modeling of different treatment strategies for haemophilia A with high-responding inhibitors
    • Knight C, Paisley S, Wight J, Jones ML. Economic modeling of different treatment strategies for haemophilia A with high-responding inhibitors. Haemophilia 2003;9:521-540.
    • (2003) Haemophilia , vol.9 , pp. 521-540
    • Knight, C.1    Paisley, S.2    Wight, J.3    Jones, M.L.4
  • 32
    • 0017785868 scopus 로고
    • Massive factor-VIII infusion in haemophiliac with factor-VIII inhibitor, high responder
    • Brackmann HH, Gormsen J. Massive factor-VIII infusion in haemophiliac with factor-VIII inhibitor, high responder. Lancet 1977;2:933.
    • (1977) Lancet , vol.2 , pp. 933
    • Brackmann, H.H.1    Gormsen, J.2
  • 33
    • 0030056318 scopus 로고    scopus 로고
    • Immune tolerance for the treatment of factor VIII inhibitors-twenty years' "Bonn protocol"
    • Brackmann HH, Oldenburg J, Schwaab R. Immune tolerance for the treatment of factor VIII inhibitors-twenty years' "Bonn protocol". Vox Sang 1996;70(Suppl 1):30-35.
    • (1996) Vox Sang , vol.70 , Issue.SUPPL. 1 , pp. 30-35
    • Brackmann, H.H.1    Oldenburg, J.2    Schwaab, R.3
  • 34
    • 0037710764 scopus 로고    scopus 로고
    • Immune tolerance: A synopsis of the international experience
    • DiMichele DM. Immune tolerance: a synopsis of the international experience. Haemophilia 1998;4:568-573.
    • (1998) Haemophilia , vol.4 , pp. 568-573
    • DiMichele, D.M.1
  • 35
    • 0036147943 scopus 로고    scopus 로고
    • The North American Immune Tolerance Registry: Practices, outcomes, outcome predictors
    • North American Immune Tolerance Study Group
    • DiMichele DM, Kroner BL. North American Immune Tolerance Study Group. The North American Immune Tolerance Registry: practices, outcomes, outcome predictors. Thromb Haemost 2002;87:52-57.
    • (2002) Thromb Haemost , vol.87 , pp. 52-57
    • DiMichele, D.M.1    Kroner, B.L.2
  • 36
  • 37
    • 0026635406 scopus 로고
    • Twenty-five years' experience of prophylactic treatment in severe hemophilia A and B
    • Nilsson IM, Berntorp E, Lofqvist T, Pettersson H. Twenty-five years' experience of prophylactic treatment in severe hemophilia A and B. J Intern Med 1992;232:25-32.
    • (1992) J Intern Med , vol.232 , pp. 25-32
    • Nilsson, I.M.1    Berntorp, E.2    Lofqvist, T.3    Pettersson, H.4
  • 38
    • 0031740076 scopus 로고    scopus 로고
    • Radiological and orthopedic score in pediatric hemophilic patients with early and late prophylaxis
    • Funk M, Schmidt H, Escuriola-Ettingshausen C, et al. Radiological and orthopedic score in pediatric hemophilic patients with early and late prophylaxis. Ann Hematol 1998;77:171-174.
    • (1998) Ann Hematol , vol.77 , pp. 171-174
    • Funk, M.1    Schmidt, H.2    Escuriola-Ettingshausen, C.3
  • 39
    • 0031876988 scopus 로고    scopus 로고
    • When should prophylactic treatment in patients with haemophilia A and B start? The German experience
    • Kreuz W, Escuriola-Ettinghausen C, Funck M, Schmidt H, Kornhuber B. When should prophylactic treatment in patients with haemophilia A and B start? The German experience. Haemophilia 1998;4:413-417.
    • (1998) Haemophilia , vol.4 , pp. 413-417
    • Kreuz, W.1    Escuriola-Ettinghausen, C.2    Funck, M.3    Schmidt, H.4    Kornhuber, B.5
  • 40
    • 0021299748 scopus 로고
    • Treatment of inhibitor patients with activated prothrombin complex concentrates
    • Penner JA. Treatment of inhibitor patients with activated prothrombin complex concentrates. Prog Clin Biol Res 1984;150:291-308.
    • (1984) Prog Clin Biol Res , vol.150 , pp. 291-308
    • Penner, J.A.1
  • 41
    • 0020539845 scopus 로고
    • Anti-inhibitor coagulant complex (Autoplex) in hemophilia inhibitor patients undergoing synovectomy
    • Hutchinson RJ, Penner JA, Hensinger RN. Anti-inhibitor coagulant complex (Autoplex) in hemophilia inhibitor patients undergoing synovectomy. Pediatrics 1983;71:631-633.
    • (1983) Pediatrics , vol.71 , pp. 631-633
    • Hutchinson, R.J.1    Penner, J.A.2    Hensinger, R.N.3
  • 42
    • 0019454344 scopus 로고
    • Activated factor IX complex in treatment of surgical cases of haemophilia A with inhibitors
    • Hanna WT, Madigan RR, Miles MA, Lange RD. Activated factor IX complex in treatment of surgical cases of haemophilia A with inhibitors. Thromb Haemost 1981;46:638-641.
    • (1981) Thromb Haemost , vol.46 , pp. 638-641
    • Hanna, W.T.1    Madigan, R.R.2    Miles, M.A.3    Lange, R.D.4
  • 43
    • 0016213054 scopus 로고
    • Activated prothrombin concentrate for patients with factor VIII inhibitors
    • Kurczinsky EM, Penner JA. Activated prothrombin concentrate for patients with factor VIII inhibitors. N Engl J Med 1974;291:164-167.
    • (1974) N Engl J Med , vol.291 , pp. 164-167
    • Kurczinsky, E.M.1    Penner, J.A.2
  • 44
    • 0019135948 scopus 로고
    • Anti-inhibitor coagulant complex (Autoplex) for treatment of factor VIII inhibitors in hemophilia
    • Abildgaard CF, Penner JA, Watson-Williams J. Anti-inhibitor coagulant complex (Autoplex) for treatment of factor VIII inhibitors in hemophilia. Blood 1980;56:978-984.
    • (1980) Blood , vol.56 , pp. 978-984
    • Abildgaard, C.F.1    Penner, J.A.2    Watson-Williams, J.3
  • 45
    • 0038441421 scopus 로고    scopus 로고
    • Long-term FEIBA prophylaxis does not prevent progression of existing joint disease
    • Hilgartner MW, Makipernaa A, Dimichele DM. Long-term FEIBA prophylaxis does not prevent progression of existing joint disease. Haemophilia 2003;9:261-268.
    • (2003) Haemophilia , vol.9 , pp. 261-268
    • Hilgartner, M.W.1    Makipernaa, A.2    Dimichele, D.M.3
  • 46
    • 4644221800 scopus 로고    scopus 로고
    • Prophylactic use of FEIBA in children with hemophilia complicated by high-titered inhibitors
    • abstract 3886
    • Valentino LA, Salit MG. Prophylactic use of FEIBA in children with hemophilia complicated by high-titered inhibitors. Blood 2002;100(Suppl):102B (abstract 3886).
    • (2002) Blood , vol.100 , Issue.SUPPL.
    • Valentino, L.A.1    Salit, M.G.2
  • 47
    • 79955114793 scopus 로고    scopus 로고
    • Factor VIII inhibitor bypass activity (FEIBA) for prophylaxis during immune tolerance induction (ITI) in patients with high-responding inhibitors
    • Kreuz W, Escuriola-Ettinghausen C, Mentzer D, et al. Factor VIII inhibitor bypass activity (FEIBA) for prophylaxis during immune tolerance induction (ITI) in patients with high-responding inhibitors. Blood 2000;96:266a.
    • (2000) Blood , vol.96
    • Kreuz, W.1    Escuriola-Ettinghausen, C.2    Mentzer, D.3
  • 48
    • 79955114793 scopus 로고    scopus 로고
    • Efficacy and safety of factor VIII inhibitor bypass activity (FEIBA) for long-term prophylaxis in patients with high-responding inhibitors
    • Kreuz W, Escuriola-Ettinghausen C, Martinez I, Mentzer D, Figura S, Klarmann D. Efficacy and safety of factor VIII inhibitor bypass activity (FEIBA) for long-term prophylaxis in patients with high-responding inhibitors. Blood 2000;96:265a.
    • (2000) Blood , vol.96
    • Kreuz, W.1    Escuriola-Ettinghausen, C.2    Martinez, I.3    Mentzer, D.4    Figura, S.5    Klarmann, D.6
  • 49
    • 4644303325 scopus 로고    scopus 로고
    • Prophylactic treatment of severe FVIII deficiency with inhibitor with prothrombin complex concentrates
    • Kulzer L, Kouides PA. Prophylactic treatment of severe FVIII deficiency with inhibitor with prothrombin complex concentrates. Hemaware 2001;6:4.
    • (2001) Hemaware , vol.6 , pp. 4
    • Kulzer, L.1    Kouides, P.A.2
  • 50
    • 0028004222 scopus 로고
    • A longitudinal study of orthopaedic outcomes for severe factor-VIII-deficient haemophiliacs
    • The Orthopaedic Outcome Study Group
    • Aledort LM, Haschmeyer RH, Pettersson H. A longitudinal study of orthopaedic outcomes for severe factor-VIII-deficient haemophiliacs. The Orthopaedic Outcome Study Group. J Intern Med 1994;236:391-399.
    • (1994) J Intern Med , vol.236 , pp. 391-399
    • Aledort, L.M.1    Haschmeyer, R.H.2    Pettersson, H.3
  • 51
    • 0034003628 scopus 로고    scopus 로고
    • Epidemiological survey of the orthopaedic status of severe haemophilia A and B patients in France
    • The French Study Group
    • Molho P, Rolland N, Lebrun T, et al. Epidemiological survey of the orthopaedic status of severe haemophilia A and B patients in France. The French Study Group. Haemophilia 2000;6:23-32.
    • (2000) Haemophilia , vol.6 , pp. 23-32
    • Molho, P.1    Rolland, N.2    Lebrun, T.3


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