Immune tolerance and the immune modulation protocol

Vox Sanguinis

Volumn 70, Issue SUPPL. 1, 1996, Pages 36-41

  Berntorp, E ^a   Nilsson, I M ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BLOOD CLOTTING FACTOR 8 CONCENTRATE; BLOOD CLOTTING FACTOR 9 CONCENTRATE; CYCLOPHOSPHAMIDE;

AUTOIMMUNITY; CLINICAL PROTOCOL; COMPLICATION; CONFERENCE PAPER; DRUG THERAPY; HEMOPHILIA; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; ORAL DRUG ADMINISTRATION; PREVENTION; PRIORITY JOURNAL; PROPHYLAXIS; THERAPY;

EID: 0030044206     PISSN: 00429007     EISSN: None     Source Type: Journal    
DOI: 10.1159/000462140     Document Type: Conference Paper

References (7)

1. Nilsson IM, Berntorp E, Löfqvist T, Pettersson H: Twenty-five years' experience of prophylactic treatment in severe haemophilia A and B. J Int Med 1992;232:25-32.
2. Brackmann H-H: Induced immunotolerance in factor VIII inhibitor patients. Prog Clin Biol Res 1984;150:181-185.
3. Rizza CR. The management of haemophiliacs who have antibodies to factor VIII. Scand J Haematol (Suppl) 1984;40:187-193.
4. Van Leeuwen EF, Mauser-Bunschoten EP, van Dijken PJ, Kok AL, Sjamsoedin-Visser EJM, Sixma JJ: Disappearance of factor VIII:C antibodies in patients with haemophilia A upon frequent administration of factor VIII in intermediate or low dose. Br J Haematol 1986;64.291-297.
5. Ewing N, Sanders NL, Dietrich SL, Kasper CK: Induction of immune tolerance to factor VIII in hemophiliacs. JAMA 1988;259:65-68.
6. Nilsson IM, Berntorp E, Zettervall O: Induction of split tolerance and clinical cure in high-responding hemophiliacs with factor IX antibodies. Proc Natl Acad Sci USA 1986;83:9169-9173.
7. Nilsson IM, Berntorp E, Zettervall O: Induction of immune tolerance in patients with hemophilia and antibodies to factor VIII by combined treatment with intravenous IgG, cyclophosphamide, and factor VIII. N Engl J Med 1988;318:947-950.