A novel inhibitor of indole-3-glycerol phosphate synthase with activity against multidrug-resistant Mycobacterium tuberculosis

FEBS Journal

Volumn 276, Issue 1, 2009, Pages 144-154

  Shen, Hongbo ^a   Wang, Feifei ^a   Zhang, Ying ^b   Huang, Qiang ^a   Xu, Shengfeng ^a   Hu, Hairong ^a   Yue, Jun ^c   Wang, Honghai ^a  

^a FUDAN UNIVERSITY   (China)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c SHANGHAI PULMONARY HOSPITAL   (China)

Author keywords

Drug resistance; Indole 3 glycerol phosphate synthase; Inhibitor; Mycobacterium tuberculosis

Indexed keywords

ASPARAGINE; ATB 107; GLUTAMIC ACID; INDOLE 3 GLYCEROL PHOSPHATE SYNTHASE; INDOLE 3 GLYCEROL PHOSPHATE SYNTHASE INHIBITOR; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIAL SURVIVAL; DRUG STRUCTURE; ENZYME STRUCTURE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; DRUG RESISTANCE, MULTIPLE; ENZYME INHIBITORS; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; QUINUCLIDINES; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; THERMUS THERMOPHILUS; TRIAZINES;

ANIMALIA; MYCOBACTERIUM TUBERCULOSIS;

EID: 57649146532     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2008.06763.x     Document Type: Article

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