Urinary matrix metalloproteinases reflect renal damage in anti-neutrophil cytoplasm autoantibody-associated vasculitis

American Journal of Physiology - Renal Physiology

Volumn 293, Issue 6, 2007, Pages

  Sanders, Jan Stephan F ^a   Huitema, Minke G ^a   Hanemaaijer, Roeland ^b   Van Goor, Harry ^a   Kallenberg, Cees G M ^a   Stegeman, Coen A ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b TNO   (Netherlands)

Author keywords

ANCA associated vasculitis; Crescentic glomerulonephritis; Immunohistochemistry; MMP 2; MMP 9; Plasma levels; TIMP 1; Urinary levels

Indexed keywords

C REACTIVE PROTEIN; CREATININE; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; INTERSTITIAL NEPHRITIS; KIDNEY BIOPSY; KIDNEY INJURY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; PROTEINURIA; VASCULITIS;

EID: 36549089931     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00310.2007     Document Type: Article

References (16)

1. Bjerkeli V, Halvorsen B, Damas JK, Nordoy I, Yndestad A, Aukrust P, Froland SS. Expression of matrix metalloproteinases in patients with Wegener's granulomatosis. Ann Rheum Dis 63: 1659-1663, 2004.
2. Brown FG, Nikolic-Paterson DJ, Hill PA, Isbel NM, Dowling J, Metz CM, Atkins RC. Urine macrophage migration inhibitory factor reflects the severity of renal injury in human glomerulonephritis. J Am Soc Nephrol 13, Suppl 1: S7-S13, 2002.
3. Cheng S, Lovett DH. Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation. Am J Pathol 162: 1937-1949, 2003.
4. Faber-Elmann A, Sthoeger Z, Tcherniack A, Dayan M, Mozes E. Activity of matrix metalloproteinase-9 is elevated in sera of patients with systemic lupus erythematosus. Clin Exp Immunol 127: 393-398, 2002.
5. Falk RJ, Jennette JC. ANCA small-vessel vasculitis. J Am Soc Nephrol 8: 314-322, 1997.
6. Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol 5: 953-964, 2005.
7. Hanemaaijer R, Visser H, Konttinen YT, Koolwijk P, Verheijen JH. A novel and simple immunocapture assay for determination of gelatinase-B (MMP-9) activities in biological fluids: saliva from patients with Sjogren's syndrome contain increased latent and active gelatinase-B levels. Matrix Biol 17: 657-665, 1998.
8. Hauer HA, Bajema IM, Van Houwelingen HC, Ferrario F, Noel LH, Waldherr R, Jayne DR, Rasmussen N, Bruijn JA, Hagen EC. Determinants of outcome in ANCA-associated glomerulonephritis: a prospective clinico-histopathological analysis of 96 patients. Kidney Int 62: 1732-1742, 2002.
9. Lenz O, Elliot SJ, Stetler-Stevenson WG. Matrix metalloproteinases in renal development and disease. J Am Soc Nephrol 11: 574-581, 2000.
10. Lods N, Ferrari P, Frey FJ, Kappeler A, Berthier C, Vogt B, Marti HP. Angiotensin-converting enzyme inhibition but not angiotensin II receptor blockade regulates matrix metalloproteinase activity in patients with glomerulonephritis. J Am Soc Nephrol 14: 2861-2872, 2003.
11. Matsuyama A, Sakai N, Ishigami M, Hiraoka H, Kashine S, Hirata A, Nakamura T, Yamashita S, Matsuzawa Y. Matrix metalloproteinases as novel disease markers in Takayasu arteritis. Circulation 108: 1469-1473, 2003.
12. Sanders JS, van Goor H, Hanemaaijer R, Kallenberg CG, Stegeman CA. Renal expression of matrix metalloproteinases in human ANCA-associated glomerulonephritis. Nephrol Dial Transplant 19: 1412-1419, 2004.
13. Sorbi D, French DL, Nuovo GJ, Kew RR, Arbeit LA, Gruber BL. Elevated levels of 92-kd type IV collagenase (matrix metalloproteinase 9) in giant cell arteritis. Arthritis Rheum 39: 1747-1753, 1996.
14. Tam FW, Sanders JS, George A, Hammad T, Miller C, Dougan T, Cook HT, Kallenberg CG, Gaskin G, Levy JB, Pusey CD. Urinary monocyte chemoattractant protein-1 (MCP-1) is a marker of active renal vasculitis. Nephrol Dial Transplant 19: 2761-2768, 2004.
15. Turck J, Pollock AS, Lee LK, Marti HP, Lovett DH. Matrix metalloproteinase 2 (gelatinase A) regulates glomerular mesangial cell proliferation and differentiation. J Biol Chem 271: 15074-15083, 1996.
16. Xie B, Dong Z, Fidler IJ. Regulatory mechanisms for the expression of type IV collagenases/gelatinases in murine macrophages. J Immunol 152: 3637-3644, 1994.