Multiple genetic tests for susceptibility to smoking do not outperform simple family history

Addiction

Volumn 104, Issue 1, 2009, Pages 118-126

  Gartner, Coral E ^a   Barendregt, Jan J ^a   Hall, Wayne D ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Family history; Genetic susceptibility; Genetic test; Nicotine dependence; Screening; Smoking

Indexed keywords

ALLELE; ARTICLE; CONTROLLED STUDY; FAMILY HISTORY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MONTE CARLO METHOD; PREVALENCE; SMOKING;

ALLELES; FAMILY HEALTH; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HUMANS; PARENTS; PEDIGREE; PHENOTYPE; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; RISK FACTORS; SMOKING;

EID: 57649134327     PISSN: 09652140     EISSN: 13600443     Source Type: Journal    
DOI: 10.1111/j.1360-0443.2008.02392.x     Document Type: Article

References (60)

1. Collins F. S. Shattuck lecture - medical and societal consequences of the human genome project. N Engl J Med 1999 341 : 28 37.
2. Mathers C. D., Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006 3 : 2011 30.
3. Nutt D., Robbins T., Stimson G., Ince M., Jackson A. Drugs and the Future: Brain Science, Addiction and Society. London : Academic Press 2006.
4. Vink J. M., Willemsen G., Boomsma D. I. Heritability of smoking initiation and nicotine dependence. Behav Genet 2005 35 : 397 406.
5. Li M. D., Cheng R., Ma J. Z., Swan G. E. A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins. Addiction 2003 98 : 23 31.
6. Wilkie A. M. Polygenic Inheritance and Genetic Susceptibility Screening. Encyclopedia of Life Sciences. Chichester : John Wiley & Sons 2006.
7. Swan G. E., Hops H., Wilhelmsen K. C., Lessov-Schlaggar C. N., Cheng L. S.-C., Hudmon K. S. et al. A genome-wide screen for nicotine dependence susceptibility loci. Am J Med Genet B Neuropsychiatr Genet 2006 141B : 354 60.
8. Li M. D., Payne T. J., Ma J. Z., Lou X. Y., Zhang D., Dupont R. T. et al. A genomewide search finds major susceptibility loci for nicotine dependence on chromosome 10 in African Americans. Am J Hum Genet 2006 79 : 745 51.
9. Saccone S. F., Hinrichs A. L., Saccone N. L., Chase G. A., Konvicka K., Madden P. A. F. et al. Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet 2007 16 : 36 49.
10. Munafò M. R., Johnstone E. C. Genes and cigarette smoking. Addiction 2008 103 : 893 904.
11. Davey Smith G., Ebrahim S., Lewis S., Hansell A. L., Palmer L. J., Burton P. R. Genetic epidemiology 7 - genetic epidemiology and public health: hope, hype, and future prospects. Lancet 2005 366 : 1484 98.
12. Holtzman N. A., Marteau T. M. Will genetics revolutionize medicine? N Engl J Med 2000 343 : 141 4.
13. Consumer genomics: taking your genes in hand. Economist 2007 8 December; p. 385. Available at: http://www.economist.com/ (accessed 10 December 2007).
14. Hunter D. J., Khoury M. J., Drazen J. M. Letting the genome out of the bottle - will we get our wish? N Engl J Med 2008 358 : 105 7.
15. Human Genetics Commission. More Genes Direct: A Report on Developments in the Availability, Marketing and Regulation of Genetic Tests Supplied Directly to the Public. London : HGC 2007.
16. Yang Q. H., Khoury M. J., Botto L., Friedman J. M., Flanders W. D. Improving the prediction of complex diseases by testing for multiple disease-susceptibility genes. Am J Hum Genet 2003 72 : 636 49.
17. Janssens C. A. J. W., Pardo M. C., Steyerberg E. W., van Duijn C. M. Revisiting the clinical validity of multiplex genetic testing in complex diseases. Am J Hum Genet 2004 74 : 585 8.
18. Yang Q., Khoury M. J., Bono L., Friedman J. M., Flanders W. D. Revisiting the clinical validity of multiplex genetic testing in complex diseases: reply to Janssens et al. Am J Hum Genet 2004 74 : 588 9.
19. Ball D. Addiction science and its genetics. Addiction 2008 103 : 360 7.
20. Lerman C. E., Schnoll R. A., Munafo M. R. Genetics and smoking cessation: improving outcomes in smokers at risk. Am J Prev Med 2007 33 : S398 405.
21. Sherman W. Test targets addiction gene. New York Daily News 2006 12 February 2006: p. 28.
22. Hall W. D. Will nicotine genetics and a nicotine vaccine prevent cigarette smoking and smoking-related diseases?. PLoS Med 2005 2 : 860 3.
23. Tercyak K. P., Peshkin B. N., Abraham A., Wine L., Walker L. R. Interest in genetic counseling and testing for adolescent nicotine addiction susceptibility among a sample of adolescent medicine providers attending a scientific conference on adolescent health. J Adolesc Health 2007 41 : 42 50.
24. Tercyak K. P., Peshkin B. N., Wine L. A., Walker L. R. Interest of adolescents in genetic testing for nicotine addiction susceptibility. Prev Med 2006 42 : 60 5.
25. Hall W. D., Gartner C. E., Carter A. The genetics of nicotine addiction liability: ethical and social policy implications. Addiction 2008 103 : 347 52.
26. Zhang J., Yu K. F. What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes. JAMA 1998 280 : 1690 1.
27. Bricker J. B., Leroux B. G., Peterson A. V. J., Kealey K. A., Sarason I. G., Andersen M. R. et al. Nine-year prospective relationship between parental smoking cessation and children's daily smoking. Addiction 2003 98 : 585 93.
28. Barendregt J. J. Ersatz. 1.0 Version. Brisbane (self-published 2008.
29. Tape T. G. Interpreting diagnostic tests. University of Nebraska Medical Center. Available at: http://gim.unmc.edu/dxtests/Default.htm (accessed 10 December 2007).
30. Australian Institute of Health and Welfare (AIHW). Statistics on Drug Use in Australia 2004. AIHW cat. no. PHE 62. Drug Statistics Series no. 15. Canberra : AIHW 2005.
31. Zheng S. L., Sun J., Wiklund F., Smith S., Stattin P., Li G. et al. Cumulative association of five genetic variants with prostate cancer. N Engl J Med 2008 358 : 910 9.
32. Gartner C. E., Barendregt J. J., Hall W. D. Five genetic variants associated with prostate cancer. N Engl J Med 2008 358 : 2738 9.
33. Ioannidis J. P. A., Ntzani E. E., Trikalinos T. A., Contopoulos-Ioannidis D. G. Replication validity of genetic association studies. Nat Genet 2001 29 : 306 9.
34. Warner K. E., Burns D. M. Hardening and the hard-core smoker: concepts, evidence, and implications. Nicotine Tob Res 2003 5 : 37 48.
35. Eureka Strategic Research. Youth Tobacco Prevention Literature Review: Project number 3032. Canberra, ACT : Australian Government Department of Health and Aging 2005. Available at: http://www.health.gov.au/ (accessed 15 November 2007).
36. Li M. D., Lou X.-Y., Chen G., Ma J. Z., Elston R. C. Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence. Biol Psychiatry 2008. E-pub before print. Available at: http://dx.doi.org/10.1016/j. biopsych.2008.04.026 (accessed 1 August 2008).
37. Ton T. G., Rossing M. A., Bowen D. J., Srinouanprachan S., Wicklund K., Farin F. M. Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study. Behav Brain Funct 2007 3 : 22.
38. Lerman C., Caporaso N. E., Audrain J., Main D., Bowman E. D., Lockshin B. et al. Evidence suggesting the role of specific genetic factors in cigarette smoking. Health Psychol 1999 18 : 14 20.
39. Contopoulos-Ioannidis D. G., Kourib I. N., Ioannidis J. P. A. Genetic predisposition to asthma and atopy. Respiration 2007 74 : 8 12.
40. Noble E. P., St. Jeor S. T., Ritchie T., Syndulko K., St. Jeor S. C., Fitch R. D2 dopamine receptor gene and cigarette smoking: a reward gene? Med Hypotheses 1994 42 : 257 60.
41. Spitz M., Shi H., Yang F., Hudmon K., Jiang H., Chanberlain R. Case-control study of the D2 dopamine receptor gene and smoking status in lung cancer patients. J Natl Cancer Inst 1998 90 : 358 63.
42. Sabol S. Z., Nelson M. L., Fisher C., Gunzerath L., Brody C. L., Hu S. et al. A genetic association for cigarette smoking behavior. Health Psychol 1999 18 : 7 13.
43. Hamajima N., Ito H., Matsuo K., Saito T., Tajima K., Ando M. et al. Association between smoking habits and dopamine receptor D2 TaqI A A2 allele in Japanese males: a confirmatory study. J Epidemiol 2002 12 : 297 304.
44. Lee H. S., Kim S. H., Lee H. J., Kim L., Lee S. K., Jang D. W. et al. Gender-specific molecular heterosis of dopamine D2 receptor gene (DRD2) for smoking in schizophrenia. Am J Med Genet 2003 114 : 593 7.
45. Johnstone E. C., Yudkin P., Griffiths S. E., Fuller A., Murphy M., Walton R. The dopamine D2 receptor C32806T polymorphism (DRD2 Taq1A RFLP) exhibits no association with smoking behaviour in a healthy UK population. Addict Biol 2004 9 : 221 6.
46. Morton L. M., Wang S. S., Bergen A. W., Chatterjee N., Kvale P., Welch R. et al. DRD2 genetic variation in relation to smoking and obesity in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Pharmacogenet Genomics 2006 16 : 901 10.
47. Sullivan P. F., Jiang Y., Neale M. C., Kendler K. S., Straub R. E. Association of the tryptophan hydroxylase gene with smoking initiation but not progression to nicotine dependence. Am J Med Genet B Neuropsychiatr Genet 2001 105 : 479 84.
48. Lerman C., Caporaso N. E., Bush A., Zheng Y. L., Audrain J., Main D. et al. Tryptophan hydroxylase gene variant and smoking behavior. Am J Med Genet 2001 105 : 518 20.
49. Reuter M., Hennig J. Pleiotropic effect of the TPH A779C polymorphism on nicotine dependence and personality. Am J Med Genet B Neuropsychiatr Genet 2005 134B : 20 4.
50. Trummer O., Köppel H., Wascher T. C., Grünbacher G., Gutjahr M., Stanger O. et al. The serotonin transporter gene polymorphism is not associated with smoking behavior. Pharmacogenomics J 2006 6 : 397 400.
51. Lerer E., Kanyas K., Karni O., Ebstein R. P., Lerer B. Why do young women smoke? II. Role of traumatic life experience, psychological characteristics and serotonergic genes. Mol Psychiatry 2006 11 : 771 81.
52. Ishikawa H., Ohtsuki T., Ishiguro H., Yamakawa-Kobayashi K., Endo K., Lin Y.-L. et al. Association between serotonin transporter gene polymorphism and smoking among Japanese males. Cancer Epidemiol Biomarkers Prev 1999 8 : 831 3.
53. Hu S., Brody C. L., Fisher C., Gunzerath L., Nelson M. L., Sabol S. Z. et al. Interaction between the serotonin transporter gene and neuroticism in cigarette smoking behavior. Mol Psychiatry 2000 5 : 181 8.
54. Ito H., Hamajima N., Matsuo K., Okuma K., Sato S., Ueda R. et al. Monoamine oxidase polymorphisms and smoking behaviour in Japanese. Pharmacogenetics 2003 13 : 73 9.
55. Costa-Mallen P., Costa L. G., Checkoway H. Genotype combinations for monoamine oxidase-B intron 13 polymorphism and dopamine D2 receptor TaqIB polymorphism are associated with ever-smoking status among men. Neurosci Lett 2005 385 : 158 62.
56. Hernán M. A., Checkoway H., O'Brien R., Costa-Mallen P., De Vivo I., Colditz G. A. et al. MAOB intron 13 and COMT codon 158 polymorphisms, cigarette smoking, and the risk of PD. Neurology 2002 58 : 1381 7.
57. Tan E. K., Chai A., Lum S. Y., Shen H., Tan C., Teoh M. L. et al. Monoamine oxidase B polymorphism, cigarette smoking and risk of Parkinson's disease: a study in an Asian population. Am J Med Genet B Neuropsychiatr Genet 2003 120B : 58 62.
58. Hung R. J., Boffetta P., Brennan P., Malaveille C., Gelatti U., Placidi D. et al. Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk. Carcinogenesis 2004 25 : 973 8.
59. Guo S., Chen D. F., Zhou D. F., Sun H. Q., Wu G. Y., Haile C. N. et al. Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers. Psychopharmacology (Berl) 2007 V190 : 449 56.
60. David S. P., Johnstone E., Griffiths S. E., Murphy M., Yudkin P., Mant D. et al. No association between functional catechol O-methyl transferase 1947A > G polymorphism and smoking initiation, persistent smoking or smoking cessation. Pharmacogenetics 2002 12 : 265 8.