Revisiting the Clinical Validity of Multiplex Genetic Testing in Complex Diseases: Reply to Janssens et al. [3]

American Journal of Human Genetics

Volumn 74, Issue 3, 2004, Pages 588-589

  Yang, Quanhe ^a,c   Khoury, Muin J ^a   Botto, Lorenzo ^a   Friedman, J M ^b   Flanders, W Dana ^a  

^a EMORY UNIVERSITY   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; CLINICAL EXAMINATION; GENETIC ANALYSIS; GENETIC SCREENING; HUMAN; LETTER; MULTIFACTORIAL GENETIC DISORDER; PREDICTION; PRIORITY JOURNAL; PROBABILITY; RISK ASSESSMENT; ROC CURVE; STATISTICAL MODEL; VALIDATION PROCESS;

EID: 1542314306     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/382054     Document Type: Letter

References (8)

1. Fletcher SW (1997) Whither scientific deliberation in health policy recommendations? Alice in the Wonderland of breast-cancer screening. N Engl J Med 336:1180-1183
2. Hanley JA (1989) Receiver operating characteristic (ROC) methodology: the state of the art. Crit Rev Diagn Imaging 29:307-335
3. Harris R, Lohr KN (2002) Screening for prostate cancer: an update of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med 137:917-929
4. Jain KK (2002) Personalized medicine. Curr Opin Mol Ther 4:548-558
5. Janssens ACJW, Pardo MC, Steyerberg EW, van Duijn CM (2004) Revisiting the clinical validity of multiplex genetic testing in complex diseases. Am J Hum Genet 74:585-588 (in this issue)
6. Roses AD (2000) Pharmacogenetics and the practice of medicine. Nature 405:857-865
7. Wilson PW, D'Agostino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB (1998) Prediction of coronary heart disease using risk factor categories. Circulation 97:1837-4187
8. Yang Q, Khoury MJ, Botto L, Friedman JM, Flanders WD (2003) Improving the prediction of complex diseases by testing for multiple disease-susceptibility genes. Am J Hum Genet 72:636-649