Nephropathy in type 2 diabetes

Journal of Internal Medicine

Volumn 245, Issue 2, 1999, Pages 111-126

  Ritz, Eberhard ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

CAPD; Diabetes; Diabetes mellitus; Haemodyalisis; Hypertension; Microalbuminuria; Nephropathy

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR;

BLOOD PRESSURE; CLINICAL FEATURE; DIABETIC NEPHROPATHY; GENETIC RISK; GENETIC SUSCEPTIBILITY; GLUCOSE BLOOD LEVEL; HEMODIALYSIS; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERTENSION; KIDNEY ARTERY STENOSIS; KIDNEY POLYCYSTIC DISEASE; NEPHROSCLEROSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROGNOSIS; REFLUX NEPHROPATHY; REVIEW; RISK FACTOR; SMOKING;

ALBUMINURIA; CAUSALITY; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DISEASE PROGRESSION; HUMANS; KIDNEY FAILURE, CHRONIC; RENAL DIALYSIS;

EID: 0032987258     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2796.1999.00411.x     Document Type: Review

References (101)

1. Renal Data System. USRDS 1996 Annual Data Report. Bethesda: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 1996.
2. Lippert J, Ritz E, Schwarzbeck A, Schneider P. The rising tide of endstage renal failure from diabetic nephropathy type 2 - an epidemiological analysis. Nephrol Dial Transplant 1995; 10: 462-7.
3. Raine AE. Epidemiology, development and treatment of end-stage renal failure in type 2 (non-insulin-dependent) diabetic patients in Europe. Diabetologia 1993; 36: 99-104.
4. Fabre J, Balant LP, Dayer PG, Fox HM, Vernet AT. The kidney in maturity onset diabetes mellitus: a clinical study of 510 patients. Kidney Intern 1982; 21: 730-8.
5. Palumbo PJ, Elveback ER, Chu CP, Connolly DC, Kurland LT. Diabetes mellitus: incidence, prevalence, survivorship, and causes of death in Rochester, Minnesota, 1945-1970. Diabetes 1976; 25: 566-73.
6. Hasslacher C, Ritz E, Wahl P, Michael C. Similar risks of nephropathy in patients with type 1 or type 2 diabetes mellitus. Nephrol Dial Transplant 1989; 4: 859-63.
7. Biesenbach G, Janko O, Zazgornik J. Similar rate of progression in the predialysis phase in type 1 and type 2 diabetes mellitus. Nephrol Dial Transplant 1994; 9: 1097-102.
8. Ritz E, Stefanski A. Diabetic nephropathy in type 2 diabetes. Am J Kidney Dis 1996; 27: 167-94.
9. Rubin RJ, Altman WM, Mendelson DN. Health care expenditure for people with diabetes mellitus, 1992. J Clin Endocrinol Metab 1994; 78: 809.
10. Ritz E, Lippert J, Keller C. Rapider Anstieg der Zahl nierenin-suffizienter Typ II Diabetiker. Nicht nur ein Problem der Nephrologen (Leitartikel). Dtsch Med Wschr 1996; 121: 1247-8.
11. Ritz E, Lippert J, Keller C. Rapider Anstieg der Zahl nierenin-suffizienter Typ II Diabetiker. Dtsch Med Wschr 1996; 121: 1247-8.
12. Amoah E, Glickman JL, Malchoff CD, Sturgill BC, Kaiser DL, Bolton WK. Clinical identification of non-diabetic renal disease in diabetic patients with type 1 and type 2 disease presenting with renal dysfunction. Am J Nephrol 1988; 8: 204-11.
13. Parving HH, Gall MA, Skott P, Jorgensen HE, Lokkegaard H, Jorgensen F et al. Prevalence and causes of albuminuria in non-insulin-dependent diabetic patients. Kidney Intern 1992; 41: 758-62.
14. Waldherr R, Ilkenhaus C, Ritz E. How frequent is glomerulonephritis in diabetes mellitus type 2? Clin Nephrol 1992; 37: 271-3.
15. McManus JFA, Davis HG, Bishop BH. Clinical cure of diabetes mellitus during intercapillary glomerulosclerosis. Am J Pathol 1951; 27: 752-63.
16. Catalano C, Postorino M, Kelly PJ, Fabrizi F, Enia G, Goodship TH et al. Diabetes mellitus and renal replacement therapy in Italy: prevalence, main characteristics and complications. Nephrol Dial Transplant 1990; 5: 788-96.
17. Seaquist ER, Gotz FC, Rich S, Barbosa J. Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy. N Engl J Med 1989; 320: 1161-5.
18. Pettitt DJ, Saad MF, Bennett PH, Nelson RG, Knowler WC. Familial predisposition to renal disease in two generation of Pima Indians with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1990; 33: 438-43.
19. Haffner SM, Gonzales C, Valdez RA, Mykkanen L, Hazuda HP, Mitchell BD et al. Is microalbuminuria part of the prediabetic state? The Mexico City Diabetes Study. Diabetologia 1993; 36: 1002-6.
20. Keller CK, Bergis KG, Flkiser D, Ritz E. Renal findings in patients with short term type 2 diabetes. JASN 1996; 7: 2627-35.
21. Cowie CC, Port FK, Wolfe RA, Savage PJ, Moll PP, Hawthorne VM. Disparities in incidence of diabetic endstage renal disease according to race and type of diabetes. N Engl J Med 1989; 321: 1074-9.
22. Strojek K, Grzeszczak W, Morawin E, Adamski M, Lacka B, Rudzki H et al. Nephropathy of type 2 diabetes: evidence for hereditary factors? Kidney Int 1997; 51: 1602-7.
23. Schmidt S, Ritz E. Genetic determinants of diabetic renal disease and their impact on therapeutic interventions. Kidney Int 1997; 52: S27-S31.
24. Siffert W, Rosskopf D, Moritz A, Wieland T, Kaldenberg-Stach S, Kettler N et al. Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension. J Clin Invest 1995; 96: 759-66.
25. Ruiz J, Blanche H, Cohen N, Velho G, Cambien F, Cohen D et al. Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 1994; 91: 3662-5.
26. Marre M, Bernadet P, Gallois Y, Savagner F, Guyene TT, Hallab M et al. Relationships between angiotensin I converting enzyme gene polymorphism, plasma levels, and diabetic retinal and renal complications. Diabetes 1994; 43: 384-8.
27. Parving HH, Tarnow L, Rossing P. Genetics of diabetic nephropathy. J Am Soc Nephrol 1996; 7: 2509-17.
28. Tarnow L, Cambien F, Rossing P, Nielsen FS, Hansen BV, Lecerf L et al. Lack of relationship between an inssertion/deletion polymorphism in the angiotensin I converting enzyme gene and diabetic nephropathy in IDDM patients. Diabetes 1995; 44: 489-94.
29. Schmidt S, Schöne N, Ritz E, Diabetic Nephropathy Study Group. Association of ACE gene polymorphism and diabetic nephropathy. Kidney Int 1995; 47: 1176-81.
30. Doi Y, Yoshizumi H, Yoshinari M, Sino K, Yamamoto M, Ichikawa K et al. Association between a polymorphism in the angiotensin converting enzyme gene and microvascular complications in Japanese patients with NIDDM. Diabetologia 1996; 39: 97-102.
31. Mizuiri S, Hemmi H, Inoue A. Angiotensin converting enzyme polymorphism and development of diabetic nephropathy in non-insulin-dependent diabetes mellitus. Nephron 1995; 70: 455-9.
32. Ohno T, Kawazu S, Tomono S. Association analyses of the polymorphism of angiotensin converting enzyme and angiotensinogen genes with diabetic nephropathy in Japanese non-insulin-dependent diabetics. Metabolism 1996; 45: 218-22.
33. Dudley CRK, Keavney B, Straton IM, Turner RC, Ratcliffe PJ. UK Prospective Diabetes Study XV: relationship of reninangiotensin system gene polymorphism with microalbuminuria in NIDDM. Kidney Int 1995; 48: 1907-11.
34. Schmidt S, Strojek K, Grzeszczak W, Bergis K, Ritz E. Excess of DD homocygotes in hemodialysed patients with type 2 diabetes. Nephrol Dial Transplant 1997; 12: 427-9.
35. Krolewski AS, Canessa M, Warram JH, Laffel LM, Christlieb AR, Knowler WC, Rand H. Predisposition to hypertension and susceptibility to renal disease in insulin-dependent diabetes mellitus. N Engl J Med 1988; 318: 140-5.
36. Mangili R, Bending JJ, Scott G, Li LK, Gupta A, Viberti GC. Increased sodium-lithium countertransport activity in red cells of patients with insulin-dependent diabetes and nephropathy. N Engl J Med 1988; 318: 146-50.
37. Jensen JS, Mathiesen ER, Norgaard K, Homel E, Borch-Johnsen K, Funder J et al. Increased blood pressure and erythrocyte sodium-lithium countertransport activity are not inherited in diabetic nephropathy. Diabetologia 1990; 33: 619-24.
38. Pinkey JH, Foyle WJ, Denver AE, Mohamed-Ali V, McKinlay S, Yudkin JS. The relationship to urinary albumin excretion rate to ambulatory blood pressure and erythrocyte sodium-llithium countertransport in NIDDM. Diabetologia 1995; 38: 356-62.
39. Rutherford PA, Thomas TH, Taylor R, Wilkinson R. Nephropathy and changes in sodium-lithium countertransport kinetics in type 2 (non-insulin-dependent) diabetes mellitus. J Hum Hypertens 1994; 8: 29-35.
40. Pietruck F, Spleiter S, Danl A, Philipp T, Derwah M, Schatz H, Siffert W. Enhanced G protein activation in IDDM patients with diabetic nephropathy. Diabetologia 1998; 41: 94-100.
41. Ballard DJ, Humphrey LL, Melton LJ, Frohnert PP, Chu PC, O'Fallon WM et al. Epidemiology of persistent proteinuria in type 2 diabetes melllitus. Population based study in Rochester, Minnesota. Diabetes 1988; 37: 405-12.
42. Vasquez B, Flock EV, Savage PJ, Nagulesparan M, Bennion LJ, Baird HR, Bennett PH. Sustained reduction of proteinuria in type 2 (non-insulin-dependent) diabetes following diet-induced reduction of hyperglycemia. Diabetologia 1984; 26: 127-33.
43. Ohkubo Y, Kishikawa H, Araki E. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6 year study. Diabetes Res 1995; 28: 103-17.
44. Nosadini R, Solini A, Velussi M, Muollo B, Frigato F, Sambataro M et al. Impaired insulin-induced glucose uptake by extrahepatic tissue is hallmark of NIDDM patients who have or will develop hypertension and microalbuminuria. Diabetes 1994; 43: 491-4.
45. Niskanen L, Laakso M. Insulin resistance is related to albuminuria in patients with type 2 diabetes mellitus. Metabolism 1993; 42: 1541-5.
46. Mykkanen L, Haffner SM, Kuusisto J, Pyorala K, Laakso M. Microalbuminuria precedes the development of NIDDM. Diabetes 1994; 43: 552-7.
47. Berkman J, Rilkin H. Unilateral nodular diabetic glomlerulosclerosis (Kimmelstiel Wilson). Report of a case. Metabolism 1973; 22: 715-22.
48. Maranon G. Über Hypertonie und Zuckerkrankheit. Zentralblatt Innere Med 1922; 43: 169-81.
49. Stern MP. Diabetes and cardiovascular disease. The 'common soil' hypothesis. Diabetes 1995; 44: 369-74.
50. Nelson RG, Pettitt DJ, Baird HR, Charles MA, Liu QZ, Bennett PH, Knowler WC. Prediabetic blood pressure predicts urinary albumin secretion after the onset of type 2 diabetes mellitus in Pima Indians. Diabetologia 1993; 36: 998-1001.
51. Pugh JA, Medina R, Ramirez M. Comparison of the course to endstage renal disease of type 1 and type 2 diabetic nephropathy. Diabetologia 1993; 36: 1094-8.
52. Mühlhauser I, Sawicki P, Berger M. Cigarette smoking as a risk factor for macroproteinuria and proliferative retinopathy in type 1 diabetes. Diabetologia 1986; 29: 500-2.
53. Sawicki PT, Didjurgeit U, Mühlhauser I, Bender R, Heinemann L, Berger M. Smoking is associated with progression of diabetic nephropathy. Diabetes Care 1994; 17: 126-31.
54. Orth S, Ritz E, Schrier R. The renal risk of smoking. Kidney Int 1997; 51: 1669-77.
55. Olivarus NF, Andreasen AH, Keiding N, Mogensen CE. Epidemiology of renal involvement in newly diagnosed middle-aged and elderly diabetic patients. Cross-sectional data from the population-based study 'Diabetes Care in General Practice'. Denmark Diabetologia 1993; 36: 1007-16.
56. Haffner SM, Gonzales C, Caldez RA, Mykkanen L, Hazuda HP, Mitchell BK, Monterrosa A, Stern MP. Is microalbuminuria part of the prediabetic state? The Mexico City Diabetes Study. Diabetologia 1993; 36: 1002-6.
57. Standl E, Stiegler H. Microalbuminuria is a random cohort of recently diagnosed type 2 diabetic patients living in the greater Munich area. Diabetologia 1993; 36: 1017-20.
58. UK Prospective Diabetes Study (UKPDS): IX. Relationships of urinary albumin and N-acetylglucosaminidase to glycemia and hypertension at diagnosis of type 2 (non-insulin-dependent) diabetes mellitus and after 3 months diet therapy. Diabetologia 1993; 36: 834-42.
59. Gall MA, Rossing P, Skott P, Damsbo P, Vaag A, Bech K et al. Prevalence of micro- and macroalbuminuria, arterial hypertension, retinopathy and large vessel disease in European type 2 diabetic patients. Diabetologia 1991; 34: 655-61.
60. Mogensen CE, Christensen CK. Predicting diabetic nephropathy in insulin-dependent patients. N Engl J Med 1984; 311: 89-93.
61. Mogensen CE. Microalbuminuria predicts clinical proteinuria and early mortality in maturity onset diabetes. N Engl J Med 1984; 310: 356-60.
62. Mogensen CE. Microalbuminuria as a predictor of clnical diabetic nephropathy. Kidney Int 1987; 31: 673-89.
63. Mattock MB, Morrish NJ, Viberti GC, Keen H, Fitzgerald AP, Jackson G. Prospective study of microalbuminuria as predictor of mortality in NIDDM. Diabetes 1992; 41: 736-41.
64. Bennett PH, Haffner JS, Kasiske BL, Keane WF, Mogensen CE, Parving HH et al. Screening and management of microalbuminuria in patients with diabetes mellitus: recommendations to the scientific advisory board of the National Kidney Foundation from an Ad Hoc Commmittee of the Council on Diabetes Mellitus of the National Kidney Foundation. Am J Kidney Dis 1995; 25: 107-12.
65. Mogensen CE, Keane WF, Bennet PH, Jerums G, Parving HH, Passa P et al. Prevention of diabetic renal disease with special reference to microalbuminuria. Lancet 1995; 346: 939-45.
66. Uusitupa M, Siitonen O, Aro A, Pyorala K. Prevalence of coronary heart disease, left ventricular failure and hypertension in middle aged, new diagnosed type 2 diabetic subjects. Diabetologia 1985; 28: 22-7.
67. Walker WG, Hermann J, Murphy R, Patz A. Elevated blood pressure and angiotensin II are associated with accelerated loss of renal function in diabetic nephropathy. Trans Am Clin Climatol Assoc 1985; 97: 94-104.
68. Biesenbach G, Janko O, Zazgornik J. Similar rate of progression in the predialysis phase in type 1 and type 2 diabetes mellitus. Nephrol Dial Transplant 1994; 9: 1097-102.
69. Pernegger TV, Brancati FL, Whelton PK, Klag MJ. Endstage renal disease attributable to diabetes mellitus. Ann Intern Med 1994; 121: 912-8.
70. Hasslacher C, Wolfrum M, Stech G, Wahl P, Ritz E. Diabetische Nephropathie bei Typ II Diabetes. Dtsch Med Wschr 1987; 112: 1445-9.
71. Ravid M, Savin H, Juttrin I, Bental T, Katz B, Lishner M. Long-term stabilising effect of angiotensin-converting enzyme inhibition on plasma creatinine and on proteinuria in normotensive type 2 diabetic patients. Ann Intern Med 1993; 118: 557-81.
72. Sano T, Kawamura T, Matsumae H, Sasaki H, Nakayama M, Hara T et al. Effects of long term enalapril treatment on persistent microalbuminuria in well controlled hypertensive and normotensive NIDDM patients. Diabetes Care 1994; 17: 420-4.
73. Viberti GC, Mogensen CE, Groop LC, Pauls JF. Effect of captopril on progression to clinical proteinuria in patients with insulin dependent diabetes mellitus and microalbuminuria. JAMA 1994; 271: 275-9.
74. Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin-converting enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med 1993; 329: 1456-62.
75. Peterson JC, Adler S, Burkart JM, Greene T, Herbert LA, Hunsicker LG et al. Blood pressure control, proteinuria, and the progression of renal disease. Ann Int Med 1995; 123: 754-62.
76. Melkin J, Hellberg O, Akyürek M, Källskog Ö, Larsson E, Fellström BC. Ischemia cause rapidly progressive nephropathy in the diabetic rat. Kidney Int 1997; 52: 985-91.
77. The GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia). Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. Lancet 1997; 349: 1857-63.
78. Weidmann P, Boehlen LM, de Courten M. Effects of different antihypertensive drugs on human diabetic protenuria. Nephrol Dial Transplant 1993;8:582-4.
79. Kasiske BL, Kalil RSN, Ma JZ, Liao M. Effect of antihypertensive therapy on the kidney in patients with diabetes: a meta-regression analysis. Ann Intern Med 1993; 118: 129-39.
80. Maschio G, Alberti D, Janin G, Locatelli F, Mann JFE, Motolese M et al. & the Cooperative AIPRI (ACE Inhibition in Progressive Renal Insufficiency) Study Group. The effect of the angiotensin converting enzyme inhibitor benazepril on progression of chronic renal insufficiency. New Engl J Med 1996; 334: 939-45.
81. Bakris GL, Copley JB, Vicknair N, Sadler R, Leurgans S. Calcium channel blockers vs. other antihypertensive therapies on progression of NIDDM associated nephropathy. Kidney Int 1996; 50: 1641-50.
82. Viberti GE, Bilous RW, Mackintosh D, Bending JJ, Keen H. Long term correction of hyperglycemia and progression of renal failure in insulin-dependent diabetes. Br Med J 1983; 286: 598-601.
83. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of longterm complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977-86.
84. Nyberg G, Blohme G, Norden G. Impact of metabolic control in progression of clinical diabetic nephropathy. Diabetologia 1987; 30: 82-6.
85. Kawazu S, Tomono S, Shimizu M, Kato N, Ohno T, Ishii C et al. The relationship between early diabetic nephropathy and control of plasma glucose in non-insulin-dependent diabetes mellitus. The effect of glycemic control on the development and progression of diabetic nephropathy in an 8 year follow-up study. J Diabet Complications 1994; 8: 13-7.
86. Wainai H, Katsukawa F, Takei I, Maryama H, Kataoka K, Saruta T. Influence of glycemic control and hypertension on urinary microprotein excretion in non-insulin-dependent diabetes mellitus. J Diabet Complications 1991; 5: 160-1.
87. Gilbert RE, Tsaiamandris C, Bach LA, Panagiotopoulos S, O'Brien RC, Allen TJ et al. Longterm glycemic control and the rate of progression of early diabetic kidney disease. Kidney Int 1993; 44: 855-9.
88. Hasslacher C, Bostedt-Kiesel A, Kempe HP, Wahl P. Effect of metabolic factors and blood pressure on kidney function in proteinuric type 2 diabetic patients. Diabetologia 1993; 36: 1051-6.
89. Wu MS, Yu CC, Yang CW, WUCH.Haung JY, Hong IJ et al. Poor pre-dialysis glycemic control is a predictor of mortality in type 2 diabetic patients on maintenance hemodialysis. Nephrol Dial Transplant, 1997; 12: 2105-10.
90. Toeller M, Buyken A, Heitkamp G, Brämswig S, Mann J, Milne R et al. and the EURODIABIDDM. Complications Study Group. Protein intake and urinary albumin excretion rates in the EURODIAB IDDM Complications Study. Diabetologia 1997; 40: 1219-26.
91. Ritz E, Mogensen CE, Cordonnier DJ. Renal failure due to diabetes mellitus. In: Davison A, Cameron J, Kerr D, Ritz E, Winearls C, eds. Oxford Textbook Clinical Nephrology. 2nd edn, 1998, 2273-97.
92. Manske CI, Wang Y, Rector T, Wilson RF, White CW. Coronary revascularization in insulin-dependent diabetes patients with chronic renal failure. Lancet 1992; 340: 988-1002.
93. Tschöpe W, Koch M, Thomas B, Ritz E. Serum lipids predict cardiac death in diabetic patients on maintenance hemodialysis. Results of a prospective study. The German Study Group Diabetes and Uremia. Nephron 1993; 64: 354-8.
94. Koch M, Kutkuhn B, Grabensee B, Ritz E. Apolipoprotein A. fibrinogen, age, and history of stroke are predictors or death in dialysed diabetic patients: a prospective study in 412 subjects. Nephrol Dial Transplant 1997; 12: 2603-11.
95. Foley RN, Culleton BF, Parfrey PS, Haruett JD, Kent GM, Murray DC et al. Cardiac disease in diabetic endstage renal disease. Diabetologia 1997; 40: 1307-12.
96. Maiorca R, Vonesh EF, Cavalli P, De Vecchin A, Giangrande A, La-Greca G et al. A multicenter, selection-adjusted comparison of patient and technique survivals on CAPD and hemodialysis. Perit Dial Int 1991; 11: 118-27.
97. Port FK, Wolfe RA, Manger E-A, Berling DP, Jiang K. Composition of survival probability for dialysis patients vs. cadaver removal transplant recipients. JAMA 1993; 270: 1339-43.
98. Hirschl MM. The patient with type 2 diabetes and uremia - to transplant or not to transplant. Nephrol Dial Transplant 1995; 10: 1515-6.
99. Eriksson KF, Lindgärde F. Prevention of type 2 diabetes mellitus by diet and physical exercise. Diabetologia 1991; 34: 891-8.
100. Pommer W, Bressel F, Chen F, Molzahn M. There is no room for improvement of preterminal care in diabetic patients with endstage renal failure. The epidemiological evidence in Germany. Nephrol Dial Transplant 1997; 12: 1318-21.
101. Passe P. Diabetic nephropathy in the NIDDM patient on the interface between diabetology and nephrology. What do we have to improve? Nephrol Dial Transplant 1997; 12: 1316-18.