Effects of mutations involving cysteine residues distal to the S281HCC motif at the C-terminus on the functional characteristics of a truncated ectodomain-only thyrotropin receptor anchored on glycosylphosphatidyl-inositol

Thyroid

Volumn 18, Issue 12, 2008, Pages 1313-1319

  Ho, Su Chin ^a,b   Goh, Sui Sin ^b   Li, Sun ^b   Khoo, Daphne Hsu Chin ^b   Paterson, Malcolm ^a  

^a Singapore Health Services   (Singapore)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; DISULFIDE; GLYCOSYLPHOSPHATIDYLINOSITOL; SERINE; THYROTROPIN RECEPTOR;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; LIGAND BINDING; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CYSTEINE; GLYCOSYLPHOSPHATIDYLINOSITOLS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, THYROTROPIN; THYROTROPIN;

EID: 57449109328     PISSN: 10507256     EISSN: None     Source Type: Journal    
DOI: 10.1089/thy.2008.0240     Document Type: Article

References (30)

1. Wedemeyer WJ, Welker E, Narayan M, Scheraga HA 2000 Disulfide bonds and protein folding. Biochemistry 39:4207-4216.
2. Narayan M, Welker E, Wedemeyer WJ, Scheraga HA 2000 Oxidative folding of proteins. Acc Chem Res 33:805-812.
3. Matsumura M, Signor G, Matthews BW 1989 Substantial increase of protein stability by multiple disulphide bonds. Nature 342:291-293.
4. Kadokura H, Katzen F, Beckwith J 2003 Protein disulfide bond formation in prokaryotes. Annu Rev Biochem 72:111-135.
5. Hogg PJ 2003 Disulfide bonds as switches for protein function. Trends Biochem Sci 28:210-214.
6. Chazenbalk GD, Tanaka K, McLachlan SM, Rapoport B 1999 On the functional importance of thyrotropin receptor intramolecular cleavage. Endocrinology 140:4516-4520.
7. Vassart G, Costagliola S 2004 A physiological role for the posttranslational cleavage of the thyrotropin receptor? Endocrinology 145:1-3.
8. Kosugi S, Ban T, Akamizu T, Kohn LD 1992 Role of cysteine residues in the extracellular domain and exoplasmic loops of the transmembrane domain of the TSH receptor: effect of mutation to serine on TSH receptor activity and response to thyroid stimulating autoantibodies. Biochem Biophys Res Commun 189:1754-1762.
9. Kosugi S, Mori T 1996 Cysteine-699, a possible palmitoylation site of the thyrotropin receptor, is not crucial for cAMP or phosphoinositide signaling but is necessary for full surface expression. Biochem Biophys Res Commun 221:636-640.
10. Akamizu T, Inoue D, Kosugi S, Kohn LD, Mori T 1994 Further studies of amino acids (268-304) in thyrotropin (TSH) - lutropin/chorionic gonadotropin (LH/CG) receptor chimeras: cysteine-301 is important in TSH binding and receptor tertiary structure. Thyroid 4:43-48.
11. Chazenbalk GD, Latrofa F, McLachlan SM, Rapoport B 2004 Thyroid stimulation does not require antibodies with identical epitopes but does involve recognition of a critical conformation at the N terminus of the thyrotropin receptor A-subunit. J Clin Endocrinol Metab 89:1788-1793.
12. Chen CR, Tanaka K, Chazenbalk GD, McLachlan SM, Rapoport B 2001 A full biological response to autoantibodies in Graves' disease requires a disulfide-bonded loop in the thyrotropin receptor N terminus homologous to a laminin epidermal growth factor-like domain. J Biol Chem 276:14767-14772.
13. Ho SC, van Sande J, Lefort A, Vassart G, Costagliola S 2001 Effects of mutations involving the highly conserved S281HCC motif in the extracellular domain of the thyrotropin (TSH) receptor on TSH binding and constitutive activity. Endocrinology 142:2760-2767.
14. Ho SC, Goh SS, Su Q, Khoo DH 2005 Cysteine 390 mutation of the TSH receptor modulates its ectodomain as an inverse agonist on the serpentine domain with decrease in basal constitutive activity. Mol Cell Endocrinol 245:158-168.
15. Costagliola S, Khoo D, Vassart G 1998 Production of bioactive amino-terminal domain of the thyrotropin receptor via insertion in the plasma membrane by a glycosylphosphatidylinositol anchor. FEBS Lett 436:427-433.
16. Costagliola S, Rodien P, Many MC, Ludgate M, Vassart G 1998 Genetic immunization against the human thyrotropin receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor. J Immunol 160:1458-1465.
17. Szkudlinski MW, Fremont V, Ronin C, Weintraub BD 2002 Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships. Physiol Rev 82:473-502.
18. Zhang M, Tong KP, Fremont V, Chen J, Narayan P, Puett D, Weintraub BD, Szkudlinski MW 2000 The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: implications for hormone-receptor interaction and antagonist design. Endocrinology 141:3514-3517.
19. Vlaeminck-Guillem V, Ho SC, Rodien P, Vassart G, Costagliola S 2002 Activation of the cAMP pathway by the TSH receptor involves switching of the ectodomain from a tethered inverse agonist to an agonist. Mol Endocrinol 16:736-746.
20. Kosugi S, Ban T, Akamizu T, Kohn LD 1991 Further characterization of a high affinity thyrotropin binding site on the rat thyrotropin receptor which is an epitope for blocking antibodies from idiopathic myxedema patients but not thyroid stimulating antibodies from Graves' patients. Biochem Biophys Res Commun 180:1118-1124.
21. Rapoport B, Chazenbalk GD, Jaume JC, McLachlan SM 1998 The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies. Endocr Rev 19:673-716.
22. Tanaka K, Chazenbalk GD, McLachlan SM, Rapoport B 1998 Thyrotropin receptor cleavage at site 1 does not involve a specific amino acid motif but instead depends on the presence of the unique, 50 amino acid insertion. J Biol Chem 273:1959-1963.
23. Nagayama Y, Rapoport B 1992 Role of the carboxyl-terminal half of the extracellular domain of the human thyrotropin receptor in signal transduction. Endocrinology 131:548-552.
24. Gromoll J, Wistuba J, Terwort N, Godmann M, Muller T, Simoni M 2003 A new subclass of the luteinizing hormone/chorionic gonadotropin receptor lacking exon 10 messenger RNA in the New World monkey (Platyrrhini) lineage. Biol Reprod 69:75-80.
25. Baldwin JM 1994 Structure and function of receptors coupled to G proteins. Curr Opin Cell Biol 6:180-190.
26. Probst WC, Snyder LA, Schuster DI, Brosius J, Sealfon SC 1992 Sequence alignment of the G-protein coupled receptor superfamily. DNA Cell Biol 11:1-20.
27. Kleinau G, Jaschke H, Neumann S, Lattig J, Paschke R, Krause G 2004 Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface. J Biol Chem 279:51590-51600.
28. Ceroni A, Passerini A, Vullo A, Frasconi P 2006 DISULFIND: a disulfide bonding state and cysteine connectivity prediction server. Nucleic Acids Res 34:W177-181.
29. Kaczur V, Puskas LG, Takacs M, Racz IA, Szendroi A, Toth S, Nagy Z, Szalai C, Balazs C, Falus A, Knudsen B, Farid NR 2003 Evolution of the thyrotropin receptor: a G protein coupled receptor with an intrinsic capacity to dimerize. Mol Genet Metab 78:275-290.
30. Farid NR, Szkudlinski MW 2004 Mini review: structural and functional evolution of the thyrotropin receptor. Endocrinology 145:4048-4057.