On the functional importance of thyrotropin receptor intramolecular cleavage

Endocrinology

Volumn 140, Issue 10, 1999, Pages 4516-4520

  Chazenbalk, G D ^a   Tanaka, K ^a   McLachlan, S M ^a   Rapoport, B ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; LIGAND; RECEPTOR SUBUNIT; THYROTROPIN RECEPTOR;

ANIMAL CELL; ARTICLE; CHINESE HAMSTER; DELETION MUTANT; GENE MUTATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY;

EID: 0033305275     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.10.7031     Document Type: Article

References (27)

1. Photo-affinity labelling of the thyrotropin receptor
2. A new structural model for the thyrotropin (TSH) receptor as determined by covalent crosslinking of TSH to the recombinant receptor in intact cells: Evidence for a single polypeptide chain
3. Two-subunit structure of the human thyrotropin receptor
4. Evidence that the thyrotropin receptor ectodomain contains not one, but two, cleavage sites
5. Sequential cleavage and excision of a segment of the thyrotropin receptor ectodomain
6. An N-linked glycosylation motif from the non-cleaving luteinizing hormone receptor substituted for the homologous region (Gly-367 to Glu-369) of the thyrotropin receptor prevents cleavage at its second, downstream site
7. Thyrotropin receptor cleavage at site 1 does not involve a specific amino acid motif but instead depends on the presence of the unique, 50 amino acid insertion
8. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
9. Extracellular domain chimeras of the TSH and LH/CG receptors reveal the mid-region (amino acids 171-260) to play a vital role in high affinity TSH binding
10. Is receptor cleavage into two subunits necessary for thyrotropin action?
11. In Chinese hamster ovary K1 cells dog and human thyrotropin receptors activate both the cyclic AMP and the phosphatidylinositol 4,5-bisphosphate cascades in the presence of thyrotropin and the cyclic AMP cascade in its absence
12. Genetic basis of endocrine disease: Somatic and germline mutations of the TSH receptor gene in thyroid diseases
13. 2+ cascades
14. TSH receptor and LH receptor
15. Specific activation of the thyrotropin receptor by trypsin
16. Thyrotropin-luteinizing hormone/chorionic gonadotropin receptor extracellular domain chimeras as probes for TSH receptor function
17. Role of the carboxyl-terminal half of the extracellular domain of the human thyrotropin receptor in signal transduction
18. Constitutive activation of the TSH receptor by spontaneous mutations affecting the N-terminal extracellular domain
19. Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a novel somatic mutation (serine281-isoleucine) in the extracellular domain of the thyrotropin receptor
20. Constitutive activation of the thyrotropin receptor by deletion of a portion of the extracellular domain
21. Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor
22. Both the 5' and 3' non-coding regions of the thyrotropin receptor messenger RNA influence the level of receptor protein expression in transfected mammalian cells
23. DNA sequencing with chain terminating inhibitors
24. Preparation of biologically active 125I-TSH
25. The attractions of proteins for small molecules and ions
26. Evidence for negative cooperativity among human thyrotropin receptors overexpressed in mammalian cells
27. An insertion in the human thyrotropin receptor critical for high affinity hormone binding