Cysteine 390 mutation of the TSH receptor modulates its ectodomain as an inverse agonist on the serpentine domain with decrease in basal constitutive activity

Molecular and Cellular Endocrinology

Volumn 245, Issue 1-2, 2005, Pages 158-168

  Ho, Su Chin ^a   Goh, Sui Sin ^b   Su, Qing ^b   Khoo, Daphne Hsu Chin ^b  

^a Singapore Health Services   (Singapore)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

Basal constitutive activity; Cysteine; Inverse agonist; TSH receptor

Indexed keywords

CYCLIC AMP; CYSTEINE; MUTANT PROTEIN; SERPENTINE; THYROTROPIN; THYROTROPIN RECEPTOR;

AGONIST; ARTICLE; BASAL CELL; CELL SURFACE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE SILENCING; GRAVES DISEASE; HUMAN; MUTATION; PRIORITY JOURNAL; WILD TYPE;

EID: 30044447924     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2005.11.008     Document Type: Article

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