Harman-induced changes of extracellular concentrations of neurotransmitters in the nucleus accumbens of rats

European Journal of Pharmacology

Volumn 314, Issue 1-2, 1996, Pages 75-82

  Baum, Siedy Sällström ^a   Hill, Regina ^a   Rommelspacher, Hans ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

carboline; 5 HT (5 hydroxytryptamine, serotonin); dopamine; harman; microdialysis; norharman; nucleus accumbens

Indexed keywords

3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; BETA CARBOLINE; BETA CARBOLINE DERIVATIVE; DOPAMINE; HARMAN; HOMOVANILLIC ACID; SEROTONIN;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MESOLIMBIC DOPAMINERGIC SYSTEM; MICRODIALYSIS; NEUROTRANSMITTER RELEASE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; REWARD;

ANIMALS; DOPAMINE; HARMINE; MALE; MICRODIALYSIS; NEUROTOXINS; NUCLEUS ACCUMBENS; RATS; RATS, WISTAR; SEROTONIN;

EID: 0030600524     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(96)00543-2     Document Type: Article

References (37)

1. Adell, A. and R.D. Myers, 1994, Increased alcohol intake in low alcohol drinking rats after chronic infusion of the β-carboline harman into the hippocampus, Pharmacol. Biochem. Behav. 49, 949.
2. Airaksinen, M.M. and I. Kari, 1981, β-Carbolines psychoactive compounds in the mammalian body, Med. Biol. 59, 190.
3. Airaksinen, M.M. and E. Mikkonen, 1980, Affinity of β-carbolines to rat brain benzodiazepine and opiate binding sites, Med. Biol. 58, 341.
4. Brossi, A., 1993, Mammalian alkaloids II, in: The Alkaloids, Vol. 43 (Academic Press, New York, NY) pp. 119-183.
5. Cappendijk, S.L.T., D. Fekkes and M.R. Dzoljiz, 1994, The inhibitory effect of norharman on morphine withdrawal syndrome in rats: comparison with ibogaine, Behav. Brain Res. 65, 117.
6. Colzi, A., F. D'Agostini, A.M. Cesura, E. Borroni and M.A. Da Prada, 1993, Monoamine oxidase-A inhibitors and dopamine metabolism in rat caudatus: evidence that an increased cystolic level of dopamine displaces reversible monoamine oxidase-A inhibitors in vivo, J. Pharmacol. Exp. Ther. 265, 103.
7. Dedek, J., R. Baumes, N. Tien-Duc, R. Gomeni and J. Korf, 1979, Turnover of free and conjugated (sulfhonyloxy) dihydroxyphenylacetic acid and homovanillic acid in rat striatum, J. Neurochem. 33, 687.
8. Ergene, E. and E.P. Schoener, 1993, Effects of harman (1-methyl-β-carboline) on neurones in the nucleus accumbens of the rat, Pharmacol. Biochem. Behav. 44, 951.
9. Finlay, J.M., G. Damsma and H.C. Fibiger, 1992, Benzodiazepine-induced decreases in extracellular concentrations of dopamine in the nucleus accumbens after acute and repeated administration, Psychopharmacology 106, 202.
10. Göthert, M., 1990, Presynaptic serotonin receptors in the central nervous system, Ann. N.Y. Acad. Sci. 604, 102.
11. Imperato, A. and G. Di Chiara, 1984, Trans-striatal dialysis coupled to reverse phase high performance liquid chromatography with electrochemical detection: a new method for the study of the in vivo release of endogenous dopamine and metabolites, J. Neurosci. 4, 966.
12. Juorio, A.V., I.A. Paterson and M. Zhu, 1994, Dopamine metabolism in the guinea pig striatum: role of monoamine oxidase A und B, Eur. J. Pharmacol. 254, 213.
13. Matsubara, K., M.A. Collins, A. Akane, L. Ikebuchi, E.J. Neafsey, M. Kagawa and H. Shiono, 1993, Potential bioactivated neurotoxicants, N-methylated β-carbolinium ions, are present in human brain, Brain Res. 610, 90.
14. 3H] Harman binding experiments. I: a reversible and selective radioligand for monoamine oxidase subtype A in the CNS of the rat, J. Neurochem. 56, 490.
15. 3H]harman binding and monoamine oxidase subtypes A and B activity in marmoset and rat, J. Neurochem. 56, 500.
16. May, T., A. Greube, S. Strauss, D. Heineke, J. Lehmann and H. Rommelspacher, 1994, Comparison of the in vitro binding characteristics of the β-carbolines harman and norharman in rat brain and liver and in bovine adrenal medulla. Naunyn-Schmiedeberg's Arch. Pharmacol. 349, 308.
17. Müller, W.E., K.J. Fehske, H.O. Borbe, U. Wollert, C. Nanz and H. Rommelspacher, 1981, On the neuropsychopharmacology of harman and other β-carbolines, Pharmacol. Biochem. Behav. 14, 693.
18. Nissbrandt, H., H. Waters and S. Hjorth, 1992, The influence of serotonergic drugs on dopaminergic neurotransmission in rat substantia nigra, striatum and limbic forebrain in vivo. Naunyn-Schmiedeberg's Arch. Pharmacol. 346, 12.
19. 3H]dopamine from rat nucleus accumbens and striatal slices, Neurochem. Res. 13, 403.
20. 3H]β-carboline) in the rat brain, Eur. J. Pharmacol. 147, 163.
21. Paxinos, G. and C. Watson, 1985, The Rat Brain in Stereotaxic Coordinates (Academic Press, London).
22. Pimpinella, G. and M. Palmery, 1995, Interaction of β-carbolines with central dopaminergic transmission in mice: structure-activity relationship, Neurosci. Lett, 189, 121.
23. Pletscher, A., H. Besendorf, H.P, Bächthold and K.F. Gey, 1959, Über die pharmakologische Beeinflußung des Zentralnervensystems durch kurzwirksame Monoaminoxidase-Hemmer aus der Gruppe der Harmala-Alkaloide, Helv. Physiol. Acta 17, 202.
24. Rommelspacher, H., C. Nanz, H.O. Borbe, K.J. Fehske, W.E. Müller and U. Wollert, 1980, 1-Methyl-β-carboline (harman), a potent endogenous inhibitor of benzodiazepine receptor binding, Naunyn-Schmiedeberg's Arch. Pharmacol. 314, 97.
25. Rommelspacher, H., C. Büchau and J. Weiss, 1987, Harman induces preference for ethanol in rats: is the effect specific for ethanol?, Pharmacol. Biochem. Behav. 26, 749.
26. Rommelspacher, H., T. May and B. Salewski, 1994, Harman (1-methyl-β-carboline) is a natural inhibitor of monoamine oxidase type A in rats, Eur. J. Pharmacol. 252, 51.
27. Rommelspacher, H., S. Sällström Baum and J.F. Klinker, 1995, β-Carbolines stimulate benzodiazepine-independent receptor mechanisms, Soc. Neurosci. 21, 634.1 (Abstract).
28. Rommelspacher, H., P. Dufeu and L.G. Schmidt, 1996, Harman and norharman in alcoholism: correlations with psychopathology and long-term changes, Alcoholism Clin. Exp. Res. 20, 3.
29. Sällström Baum, S., R. Hill and H. Rommelspacher, 1995, Norharman-induced changes of extracellular concentrations of dopamine in the nucleus accumbens of rats, Life Sci. 56, 1715.
30. 3H]dopamine, Eur. J. Pharmacol. 167, 309.
31. Stohler, R., H. Rommelspacher and D. Ladewig, 1995, The role of beta-carbolines (harman/norharman) in heroin addicts, Eur. J. Psychiatr. 10, 56.
32. Strömbom, J., R. Jokela, V. Saano and W. Rolfsen, 1992, Binding of strychnocarpine and related β-carbolines to brain receptors in vitro, Eur. J. Pharmacol. 214, 165.
33. 3H]dopamine release from rat.
34. Waldmeier, P.C., 1987, Amine oxidases and their endogenous substrates, J. Neural. Transm. Suppl. 23, 55.
35. Westerink, B.H.C., 1979, Further studies on the sequence of dopamine metabolism in the rat brain, Eur. J. Pharmacol. 56, 313.
36. Wise, R.A. and M.A. Bozarth, 1987, A psychomotor stimulant theory of addiction, Psychol. Rev. 94, 469.
37. Zetterström, T. and M. Fillenz, 1990, Local administration of flurazepam has different effects on dopamine release in striatum and nucleus accumbens: a microdialysis study, Neuropharmacology 29, 129.