The α1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration

Pharmacology Biochemistry and Behavior

Volumn 91, Issue 3, 2009, Pages 295-302

  Greenwell, Thomas N ^a   Walker, Brendan M ^a   Cottone, Pietro ^a   Zorrilla, Eric P ^a   Koob, George F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

alpha 1 receptor; Drug abuse; Escalation; Norepinephrine; Opiate

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; DIAMORPHINE; NORADRENALIN; PRAZOSIN; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; NARCOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ABUSE; DRUG DEPENDENCE; DRUG DOSE COMPARISON; DRUG SELF ADMINISTRATION; FEEDING BEHAVIOR; FOOD INTAKE; HEROIN DEPENDENCE; MALE; MOTIVATION; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME; WITHDRAWAL SYNDROME; ANIMAL; DRINKING; DRUG EFFECT; DRUG POTENTIATION; EATING; INSTRUMENTAL CONDITIONING; PSYCHOLOGICAL ASPECT; REINFORCEMENT; SUBSTANCE ABUSE; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING; EATING; HEROIN; HEROIN DEPENDENCE; MALE; NARCOTICS; PRAZOSIN; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; REINFORCEMENT SCHEDULE; SELF ADMINISTRATION; SUBSTANCE ABUSE, INTRAVENOUS;

EID: 57449083257     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2008.07.012     Document Type: Article

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