Conditioned place aversion is a highly sensitive index of acute opioid dependence and withdrawal

Psychopharmacology

Volumn 170, Issue 1, 2003, Pages 42-50

  Azar, Marc R ^a,b,c   Jones, Byron C ^b   Schulteis, Gery ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c Behavioral Pharma Inc   (United States)

Author keywords

Acute dependence; Conditioned place aversion; Morphine; Naloxone; Opioids

Indexed keywords

MORPHINE; NALOXONE;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AVERSIVE BEHAVIOR; COMPARTMENT MODEL; CONDITIONING; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; LONG TERM EXPOSURE; MALE; NONHUMAN; OPIATE ADDICTION; PLACE PREFERENCE; PRECIPITATION; PRIORITY JOURNAL; RAT; RELIABILITY; RISK ASSESSMENT; WITHDRAWAL SYNDROME;

ACUTE DISEASE; ANIMALS; AVOIDANCE LEARNING; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; MALE; MORPHINE; MORPHINE DEPENDENCE; NALOXONE; NARCOTIC ANTAGONISTS; NARCOTICS; RATS; RATS, WISTAR; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0242490819     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-003-1514-y     Document Type: Article

References (44)

1. Adams JU, Holtzman SG (1990) Pharmacologic characterization of the sensitization to the rate-decreasing effects of naltrexone induced by acute opioid pretreatment in rats. J Pharmacol Exp Ther 253:483-489
2. Azorlosa JL, Stitzer ML, Greenwald MK (1994) Opioid physical dependence development: effect of single versus repeated morphine pretreatments and of subjects' opioid exposure history. Psychopharmacology 114:71-80
3. Bickel WK, Stitzer ML, Liebson IA, Bigelow GE (1988) Acute physical dependence in man: effects of naloxone after brief morphine exposure. J Pharmacol Exp Ther 244:126-132
4. Cheney DL, Goldstein A (1971) Tolerance to opioid narcotics: time course and reversibility of physical dependence in mice. Nature 232:477-478
5. Delfs JM, Zhu Y, Druhan JP, Aston-Jones G (2000) Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion. Nature 403:430-434
6. Easterling KW, Holtzman SG (1997) Intracranial self-stimulation in rats: sensitization to an opioid antagonist following acute or chronic treatment with mu opioid agonists. J Pharmacol Exp Ther 281:188-199
7. Easterling KW, Plovnick RM, Holtzman SG (2000) Acute opioid but not benzodiazepine dependence in rats responding for intracranial self-stimulation. Psychopharmacology 148:263-271
8. Gellert VF, Sparber SB (1977) A comparison of the effects of naloxone upon body weight loss and suppression of fixed-ratio operant behavior in morphine-dependent rats. J Pharmacol Exp Ther 201:44-54
9. Gracy KN, Dankiewicz LA, Koob GF (2001) Opiate withdrawal-induced fos immunoreactivity in the rat extended amygdala parallels the development of conditioned place aversion. Neuropsychopharmacology 24:152-160
10. Heishman SJ, Stitzer ML, Bigelow GE, Liebson IA (1989a) Acute opioid physical dependence in humans: effect of varying the morphine-naloxone interval. I. J Pharmacol Exp Ther 250:485-491
11. Heishman SJ, Stitzer ML, Bigelow GE, Liebson IA (1989b) Acute opioid physical dependence in postaddict humans: naloxone dose effects after brief morphine exposure. J Pharmacol Exp Ther 248:127-134
12. Heishman SJ, Stitzer ML, Bigelow GE, Liebson IA (1990) Acute opioid physical dependence in humans: effect of naloxone at 6 and 24 hours postmorphine. Pharmacol Biochem Behav 36:393-399
13. Jacob JJ, Michaud GM (1974) Acute physical dependence in the waking dog after a single dose of morphine. Psychol Med 4:270-273
14. Jacob JJC, Barthelemy CD, Tremblay EC, Colombel ML (1974) Potential usefulness of single-dose acute physical dependence on and tolerance to morphine for the evaluation of narcotic antagonists. Adv Biochem Psychopharmacol 8:299-318
15. Jones RT (1980) Dependence in non-addict humans after a single dose of morphine. In: Way EL (ed) Endogenous and exogenous opiate agonists and antagonists. Pergamon Press, New York, pp 557-560
16. Kirby KC, Stitzer ML (1993) Opioid physical dependence development in human: effect of time between agonist pretreatments. Psychopharmacology 112:511-517
17. Kirby KC, Stitzer ML, Heishman SJ (1990) Acute opioid physical dependence in humans: effect varying the morphine-naloxone interval II. J Pharmacol Exp Ther 255:730-737
18. Kosersky DS, Harris RA, Harris LS (1974) Naloxone-precipitated jumping activity in mice following the acute administration of morphine. Eur J Pharmacol 26:122-124
19. Liu J, McElfresh A, Reis S, Fuqua L, Schulteis G (2002) Neuroadaptive processes in limbic and basal forebrain reward circuitry contribute to acute opioid dependence. 2002 Abstract Viewer/Itinerary Planner, Society for Neuroscience, Washington D.C., CD-ROM, program no. 310.10
20. Martin WR, Eades CG (1964) A comparison between acute and chronic physical dependence in the chronic spinal dog. J Pharmacol Exp Ther 146:385-394
21. Meyer DR, Sparber SB (1977) Evidence of possible opiate dependence during the behavioral depressant action of a single dose of morphine. Life Sci 21:1087-1094
22. Mucha RF (1987) Is the motivational effect of opiate withdrawal reflected by common somatic indices of precipitated withdrawal? A place conditioning study in the rat. Brain Res 418:214-220
23. Mucha RF, Herz A (1985) Motivational properties of kappa and mu opioid receptor agonists. Psychopharmacology 86:274-280
24. Mucha RF, Iversen SD (1984) Reinforcing properties of morphine and naloxone revealed by conditioned place preferences: a procedural examination. Psychopharmacology 82:241-247
25. Mucha RF, Millan MJ, Herz A (1985) Aversive properties of naloxone in non-dependent (naive) rats may involve blockade of central beta-endorphin. Psychopharmacology 86:281-285
26. Mucha RF, Gritti MD, Kim C (1986) Aversive properties of opiate withdrawal studied in rats. In: Holaday JW, Law P, Herz A (eds) Progress in opioid research. NIDA Res Monogr, pp 567-570
27. Nikpur J, Morse AC, Britton KT, Schulteis G (2000) Acute opioid dependence is characterized by brain reward deficits. Soc Neurosci Abstr 26:1576
28. Parker LA, Joshi A (1998) Naloxone-precipitated morphine withdrawal induced place aversions: effect of naloxone at 24 hours postmorphine. Pharmacol Biochem Behav 61:331-333
29. Parker LA, Cyr JA, Santi AN, Burton PD (2002) The aversive properties of acute morphine dependence persist 48 h after a single exposure to morphine. Evaluation by taste and place conditioning. Pharmacol Biochem Behav 72:87-92
30. Ramabadran K (1983) Naloxone-precipitated abstinence in mice, rats and gerbils acutely dependent on morphine. Life Sci 33:385-388
31. Ritzmann RF (1981) Opiate dependence following acute injections of morphine and naloxone: the assessment of various withdrawal signs. Pharmacol Biochem Behav 14:575-577
32. Santi AN, Parker LA (2001) The dopamine antagonist, alpha-flupenthixol, interferes with naloxone-induced place aversion learning, but not with acute opiate dependence in rats. Pharmacol Biochem Behav 70:193-197
33. Schnur P, Espinoza M, Flores R, Ortiz S, Vallejos S, Wainwright M (1992) Blocking naloxone-precipitated withdrawal in rats and hamsters. Pharmacol Biochem Behav 43:1093-1098
34. Schulteis G, Markou A, Gold LH, Stinus L, Koob GF (1994) Relative sensitivity to naloxone of multiple indices of opiate withdrawal: a quantitative dose-response analysis. J Pharmacol Exp Ther 271:1391-1398
35. Schulteis G, Heyser CJ, Koob GF (1997) Opiate withdrawal signs precipitated by naloxone following a single exposure to morphine: potentiation with a second morphine exposure. Psychopharmacology 129:56-65
36. Schulteis G, Heyser CJ, Koob GF (1999) Differential expression of response-disruptive and somatic indices of opiate withdrawal during the initiation and development of opiate dependence. Behav Pharmacol 10:235-242
37. Smits SE (1975) Quantitation of physical dependence in mice by naloxone-precipitated jumping after a single dose of morphine. Res Commun Chem Pathol Pharmacol 10:651-661
38. Sofuoglu M, Sato J, Takemori AE (1990) Maintenance of morphine dependence by naloxone in acutely dependent mice. J Pharmacol Exp Ther 254:841-846
39. Stinus L, Le MM, Koob GF (1990) The nucleus accumbens and amygdala as possible substrates for the aversive stimulus effects of opiate withdrawal. Neuroscience 37:767-773
40. Tallarida RJ, Murray RB (1986) Manual of pharmacologic calculations with computer programs. Springer, Berlin, Heidelberg, New York
41. Walker JR, Ahmed SH, Gracy KN, Koob GF (2000) Microinjections of an opiate receptor antagonist into the bed nucleus of the stria terminalis suppress heroin self-administration in dependent rats. Brain Res 854:85-92
42. White-Gbadebo D, Holtzman SG (1994) Acute sensitization to opioid antagonists. Pharmacol Biochem Behav 47:559-566
43. Wiley JN, Downs DA (1979) Naloxone-precipitated jumping in mice pretreated with acute injections of opioids. Life Sci 25:797-802
44. Young AM (1986) Effects of acute morphine pretreatment on the rate-decreasing and antagonist activity of naloxone. Psychopharmacology 88:201-208