Elevated levels of ferrimagnetic metals in foodchains supporting the Guam cluster of neurodegeneration: Do metal nucleated crystal contaminents evoke magnetic fields that initiate the progressive pathogenesis of neurodegeneration?

Medical Hypotheses

Volumn 63, Issue 5, 2004, Pages 793-809

  Purdey, Mark ^a  

^a High Barn Farm   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM; BARIUM; CALCIUM; FIBROBLAST GROWTH FACTOR RECEPTOR; GLUTAMATE AMMONIA LIGASE; IRON; MAGNESIUM; MANGANESE; METAL; PROTEOGLYCAN; STRONTIUM;

ALZHEIMER DISEASE; BLOOD BRAIN BARRIER; CHEMICAL STRUCTURE; CLUSTER ANALYSIS; CRYSTAL; DISEASE PREDISPOSITION; ENZYME BINDING; FOOD CHAIN; FOOD INTAKE; GUAM; HUMAN; INCIDENCE; MAGNETIC FIELD; MOTOR NEURON DISEASE; MULTIPLE SCLEROSIS; NERVE CELL NETWORK; NERVE DEGENERATION; NEUROTOXICITY; PACIFIC ISLANDER; PARKINSONISM; PATHOGENESIS; PERMEABILITY BARRIER; PRIORITY JOURNAL; REVIEW; SEA FOOD; SOIL ANALYSIS;

DIOSCOREA ALATA;

EID: 5744227901     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2004.04.029     Document Type: Article

References (91)

1. D.P. Perl ALS-Parkinsonism-dementia complex of Guam M.M. Esire J.H. Morris Neuropathology of dementia 1997 Cambridge University Press Cambridge 268 292
2. D.B. Calne, A. Eisen, E. McGeer, and P. Spencer Alzheimer's disease, Parkinson's disease, and motor neurone disease: abiotrophic interaction between ageing and environment. A hypothesis Lancet November 8th 1986 1067 1070
3. O. Sacks The island of the colourblind and cycad island 1997 Alfred Knopf New York, USA
4. Garruto RM, Yanagihara R, Gajdusek DC, Arion D. Concentrations of heavy metals and essential minerals in garden soils and drinking water. In: Chen L, Yase Y, editors. Western Pacific ALS in Asia and Oceania. Tapei: National Taiwan University; p. 265-330
5. D.M. Reed, and J.A. Brody ALS and Parkinsonism-dementia of Guam 1945-1972. 1. Descriptive epidemiology Am. J. Epidemiol. 101 1975 287 301
6. K.M. Chen Disappearance of ALS from Guam; implications for exogenous causes Rinsho-Shinkeigaku 35 12 1995 1549 1553
7. Z.X. Zhang, K.W. Anderson, and N. Mantel Geographic patterns of parkinsonism-dementia complex on Guam, 1956-1985 Arch. Neurol. 47 1990 1069 1074
8. D.C. Gajdusek Foci of motor neurone disease in high incidence in isolated populations of East Asia and the Western Pacific L.P. Rowland Human motor neurone disease 1982 Raven Press New York 363 393
9. Y. Yase The pathogenesis of ALS Lancet 2 1972 292 296
10. Tracey JI, Schlanger SO, Stark JT, Doan DB, May HG. General Geology of Guam; Geological survey professional paper 403-A. US Dept of the Interior, US government printing office, Washington, DC 20402; 1964. p. 104
11. Miller WR, Sanzolone RF. Investigation of the possible connection of rock and soil geochemistry to the occurrence of high rates of neurodegenerative diseases on Guam and a hypothesis for the cause of the diseases. Open-file report 02-475. US Dept of the Interior, US Geological Survey, Denver, CO 80225, 2002
12. M.K. Reagan, and A. Meijer Geology and geochemistry of early arc-volcanic rocks from Guam Geol. Soc. Am. Bull. 95 1984 701 713
13. D.C. Gajdusek Hypothesis: interference with axonal transport of neurofilament as a common pathogenetic mechanism in certain diseases of the CNS New England J. Med. 312 11 1985 714 718
14. B. Wolf The fertile triangle 1999 Food Products Press; An imprint of the Haworth Press Binghamton, New York
15. A.H. Frey, S.R. Field, and B. Frey Neural function and behaviour; defining the relationship Ann. NY Acad. Sci. 247 1975 433 439
16. P. Esposito, N. Chandler, K. Kandere, S. Basu, S. Jacobson, and R. Connolly Corticotropin-releasing hormone and brain mast cells regulates blood-brain-barrier permeability induced by acute stress J. Pharmacol. Exp. Ther. 303 3 2002 1061 1066
17. M. Dambska Blood-brain barrier in young rabbit brain after dichlorvos intoxication Neuropatol. Pol. 22 1984 129 137
18. M.C. Van Vulpen, H.B. Kal, M.J.B. Taphoorn, and S.Y.E. Sharouni Changes in blood brain barrier permeability induced by radiotherapy Oncol. Rep. 9 2002 683 688
19. Z. Fei, X. Zhang, X. Wang, Z. Li, P. Lu, and X. Liu The changes of rat blood brain barrier permeability and expression of heat shock protein 70 after infrasonic damage J. Low Frequency Noise Vib. Active Control 19 2 2000 93 99
20. B.R. Persson, L.G. Salford, and A. Brun Blood-brain barrier permeability in rats exposed to electromagnetic fields used in wireless communication Wireless Network 3 1997 455 461
21. A. Schirmacher, S. Winters, and S. Fisder Electromagnetic field increased permeability to sucrose of blood brain barrier in vitro Bioelectromagnetism 21 2000 338 345
22. K. Oscar, and T. Hawkins Microwave alteration of blood brain barrier system of rats Brain Res. 126 1977 281 293
23. M. Ascher, and J.L. Ascher Manganese neurotoxicity; cellular effects and blood brain barrier transport Neurosci. Biobehav. Rev. 1991 333 340
24. B. Halliwell J.M.C. Gutteridge Free radicals in biology and medicine 2nd ed. 1989 Clarendon Press Oxford, UK
25. M. Purdey Chronic barium intoxication disrupts sulphated proteoglycan synthesis; a hypothesis for the origins of multiple sclerosis Med. Hypotheses 62 5 2004 746 754
26. www.purdeyenvironment.com/Mag%20suscept%20protocol.htm
27. E.J. Underwood Trace elements in human and animal nutrition 4th ed. 1977 Academic Press New York
28. I. Pais, and J. Benton Jones The handbook of trace elements 1997 St Lucie Press Florida
29. Operation Crossroads 1946' DNA6032F; United States Atmospheric nuclear weapons tests personnel review (Human Radiation Experiments Database: Operation Crossroads 1946, Defense Nuclear Agency government pubs Dept; released September 23, 1984, pp. 142-3, 348-50, 444-7)
30. Celestial RN, Perez WC. Teaching Ethics. Society for Ethics across the curriculum, vol 3 (2), Spring 2003, Utah Valley State University; p. 87
31. H. Choudhury, and R. Cary Concise International chemical assessment document; 33 - Barium and barium compounds 2001 WHO publications Geneva
32. M. Eisenbud, and T. Gesell Environmental radioactivity 4th ed. 1997 Academic Press London
33. M.E. Evans, and F. Heller Environmental magnetism. Principles and applications of enviromagnetics 2003 Academic Press San Diego, USA
34. W. O'Reilly Rock and mineral magnetism 1984 Blackie Glasgow
35. J.A. Dearing Environmental magnetic susceptibility-using the Bartington MS2 system 2nd ed. 1999 Chi Publishing Kenilworth, UK
36. R. Thompson, and F. Oldfield Environmental magnetism 1986 George Allen and Unwin UK
37. A.F. Orchard Magnetochemistry 2003 Oxford University Press Oxford
38. Purdey M. The pathogenesis of Machado-Joseph disease; a high manganese/low magnesium induced CAG expansion mutation in susceptible genotypes? Proceedings of a conference; 10th International Magnesium symposium, Cairns, Australia. September 7-11, 2003. J Amer Coll Nutr 2004;23, in press
39. T. Burt, P. Blumbergs, and B. Currie A dominant hereditary ataxia resembling Machado-Josephs disease in Arnhem Land, Australia Neurology 43 1993 1750 1752
40. C. Kilburn Manganese, malformations and motor disorders; findings in a manganese exposed population Neurotoxicology 8 1987 421 430
41. Sacks O. Poison in Paradise. BBC 2, London, UK
42. USS Hornet (CV-12). Dictionary of American fighting ships, vol. 3. 1968. Navy Dept, Office of the Chief of Naval Operations, Naval History Division, Washington, DC
43. M.P. Alpers Kuru Chapter 16 M.P. Alpers R.D. Attenborough Human biology in Papua New Quinea 1992, Clarenden Press Melbourne 314
44. CJD surveillance in the UK. 10th Annual Report 2001. The National CJD Surveillance Unit, Western General Hospital, Edinburgh EH4 2XU
45. B. Aberg F.P. Hungate Radioecological concentration processes 1966 Pergamon Press New York
46. Donaldson LR, Seymour AH, Nevissi AE. University of Washington's Radioecological studies in the Marshall islands, 1946-1977
47. A.P. Dowling, and J.E. Williams Sound and sources of sound 1983 Ellis Horwood Chichester
48. K. Mitani Relationship between aluminium load and magnesium status Magnesium Res. 5 3 1992 202 213
49. M.D. Denton, and A. Ginsberg Conformational changes in glutamine synthetase from Escherichia coli. 1. The binding of Mn in relation to some aspects of the enzyme structure and activity Biochemistry 8 4 1969 1714 1725
50. S. Karlin, Z. Zhan-Yang, and K.D. karlin The extended environment of mononuclear metal centres in protein structures Proc. Natl. Acad. Sci. USA 94 1997 14225 14230
51. Frausto Da Silva, and R.J.P. Williams The Biological chemistry of the elements 2nd ed. 2001 Oxford University Press Oxford
52. D. Grant, W.F. Long, and F.B. Williamson Infrared spectroscopy of heparin-cation complexes Biochem. J. 244 1987 143 149
53. D. Grant, W.F. Long, and F.B. Williamson A potentiometric titration study of the interaction of heparin with metal cations Biochem. J. 285 1992 477 480
54. M. Kan, F. Wang, M. Kan, B. To, J.L. Gabriel, and W.L. McKeehan Divalent cations and heparin/heparan sulphate cooperate to control assembly and activity of the fibroblast growth factor receptor complex The Am. Soc. Biochem. Mol. Biol. 271 42 1996 26143 26148
55. R.G. Cutler, W.A. Pederson, S. Camandola, J.D. Rothskin, and M.P. Mattson Evidence that accumulation of ceramides and cholesterol esters mediate oxidative stress induced death of motor neurones in ALS Ann. Neurol. 52 2002
56. T. Siddique Nature Genet. 3 October 2001
57. H.J. Fore E. Cadenas Oxidative stress and signal transduction 1997 Chapman and Hall New York
58. M. Purdey Ecosystems supporting clusters of sporadic TSEs demonstrate excesses of the radical generating divalent cation, manganese, and deficiencies of antioxidant co factors Cu, Se, Fe, Zn. Does a foreign cation substitution at Prp's Cu domain initiate TSE Med. Hypotheses 54 2 2000 278 306
59. M. Bara, A. Guiet-Bara, and J. Durlach Regulation of sodium and potassium pathways by magnesium in cell membranes Magnesium Res. 6 2 1993 167 177
60. K. Schulten Magnetic field effects in chemistry and biology Adv. Solid State Phys. 22 1982 61 83
61. B. Brocklehurst, and K.A. McLauchlan Free radical mechanism fopr the effects of environmental electromagnetic fields on biological systems Int. J. Radiat. Biol. 69 1 1996 3 24
62. C.R. Timmel, U. Till, B. Brocklehurst, K.A. Mclauchlan, and P.J. Hore Effects of weak magnetic fields on free radical recombination reactions Mol. Phys. 95 1 1998 71 89
63. D.T. Edmonds Electricity and magnetism in biological systems 2001 Oxford University Press Oxford
64. H.W. De Valk Magnesium in diabetes mellitus Neth. J. Med. 54 1999 139 146
65. L.T. Iseri, J. Freed, and A.R. Bures Magnesium deficiency and cardiac disorders Am. J. Med. 58 6 1975 837 846
66. T.M. Devlin Textbook of biochemistry with clinical correlations 3rd ed. 1992 Wiley-Liss New York
67. P.S. Spencer H.H. Schaumburg Experimental and clinical neurotoxicology 2nd ed. 2000 Oxford University Press Oxford
68. D.W. Choi Glutamate neurotoxicity and diseases of the nervous system Neuron 1 1988 623 634
69. + channels J. Neurochem. 61 1993 1220 1230
70. S. Winkler, R.C. Stahl, D.J. Carey, and R. Bansal Syndecan-3 and perlecan are differentially expressed by progenitors and mature oligodendrocytes and accumulate in the extracellular matrix J. Neurosci. Res. 69 4 2002 477 487
71. S.E. Stringer, M. Mayer-Proschel, A. Kalyani, M. Rao, and J.T. Gallagher Heparin is a unique marker of progenitors in the Glial cell lineage J. Biol. Chem. 274 36 1999 25455 25460
72. N. Perriman, and M. Bernfield Nature 404 2000 725 728
73. K. Lund-Olesen Etiology of MS: role of superoxide dismutase Med. Hypotheses 54 2 2000 321 322
74. A.I. Bush Metals and Neuroscience Curr. Opin. Chem. Biol. 4 2000 184 191
75. J.R. Cooper, F.E. Bloom, and R.H. Roth The biochemical basis of neuropharmacology 7th ed. 1996 Oxford University Press New York
76. Markianos M, Sfagos C. Altered serotonin uptake kinetics in MS. J Neurol 88 235(4):236-7
77. M. Perez, F. Wandosell, C. Colaco, and J. Avila Sulphated glycoaminoglycans prevent neurotoxicity of a human prion protein fragment Biochem. J. 335 1998 369 374
78. www.purdeyenvironment/web%20references.htm
79. J.L. Kirschvink, A. Kobayashi-Kirschvink, and B.J. Woodford Magnetite biomineralisation in the human brain Proc. Natl. Acad. Sci. USA 89 1992 7683 7687
80. J.L. Kirschvink, and J.L. Gould Biogenic magnetite as a basis for magnetic field detection in animals Biosystems 13 1981 181 201
81. D.T. Edmonds A sensitive optically detected magnetic compass for animals Proc. R. Soc. Lond. B 263 1996 295 298
82. D.B. Dusenbery Sensory ecology 1992 WH Freeman and Co New York
83. S. Mann, T.T. Moench, and R.J.P. Williams A high resolution electron microscope investigation of bacterial magnetite Proc. Roy. Soc. B 221 1984 385 393
84. D.P. Naughton Iron (111)-mediated intra-articular crystal deposition in arthritis: a therapeutic role for iron chelators Med. Hypotheses 57 1 2001 120 122
85. J.T. Jarrett, and P.T. Lansbury Seeding one dimensional crystallization of amyloid; a pathogenic mechanism in Alzheimer's disease and Scrapie Cell 73 1993 1055 1058
86. D.C. Gajdusek Spontaneous generation of infectious nucleating amyloids in the transmissible and nontransmissible cerebral amyloidoses Mol. Neurobiol. 8 1 1994 1 13
87. Magnetic Fields; Environmental Health Criteria 69, Geneva: WHO; 1986
88. M. Lindauer, and H. Martin Die Schwere-orientierung der Beinen unter dem einfluss der Erdmagnetfeldes, A Vgl. Physiol. 60 1968 219
89. P. Semm, and R.C. Beason Magnetic responses of the trigeminal nerve system of the bobolink Neurosci. Lett. 80 1987 229 234
90. M. Purdey Elevated silver, barium and strontium in antlers, Vegetation and soils sourced from CWD cluster areas: Do Ag/Ba/Sr piezoelectric crystals represent the transmissible pathogenic agent in TSEs Med Hypotheses 63 2 2004 211 225
91. J. Collinge M.S. Palmer Prion diseases 1997 Oxford University Press Oxford