메뉴 건너뛰기




Volumn 9, Issue 4, 2002, Pages 683-688

Changes in blood-brain barrier permeability induced by radiotherapy: Implications for timing of chemotherapy? (Review)

Author keywords

Blood brain barrier; Chemotherapy; Irradiation; Mannitol; Radiotherapy

Indexed keywords

ANTINEOPLASTIC AGENT;

EID: 0036632353     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.9.4.683     Document Type: Review
Times cited : (211)

References (64)
  • 1
    • 0032936851 scopus 로고    scopus 로고
    • The cell biology of the blood-brain barrier
    • DOI 10.1146/annurev.neuro.22.1.11
    • Rubin LL and Staddon JM: The cell biology of the blood-brain barrier. Annu Rev Neurosci 22: 11-28, 1999. (Pubitemid 29144879)
    • (1999) Annual Review of Neuroscience , vol.22 , pp. 11-28
    • Rubin, L.L.1    Staddon, J.M.2
  • 2
    • 0033981738 scopus 로고    scopus 로고
    • Determinants of passive drug entry into the central nervous system
    • DOI 10.1023/A:1007001923498
    • Habgood MD, Begley DJ and Abbott NJ: Determinants of passive drug entry into the central nervous system. Cell Mol Neurobiol 20: 231-253, 2000. (Pubitemid 30091458)
    • (2000) Cellular and Molecular Neurobiology , vol.20 , Issue.2 , pp. 231-253
    • Habgood, M.D.1    Begley, D.J.2    Abbott, N.J.3
  • 4
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P and Jain RK: Angiogenesis in cancer and other diseases. Nature 407: 249-257, 2000.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 5
    • 0011909453 scopus 로고
    • Blood vessel changes following local irradiation of the brain with high energy protons
    • Larsson B: Blood vessel changes following local irradiation of the brain with high energy protons. Acta Soc Med Ups 65: 61-64, 1960.
    • (1960) Acta Soc Med Ups , vol.65 , pp. 61-64
    • Larsson, B.1
  • 6
    • 0025094551 scopus 로고
    • A review of hyperosmotic blood-brain barrier disruption in seven experimental brain tumor models
    • Blasberg RG, Groothuis D and Molnar P: A review of hyperosmotic blood-brain barrier disruption in seven experimental brain tumor models. In: Pathophysiology of the Blood-Brain Barrier. Johansson BB and Widner COH (eds). Elsevier, New York, pp 197-220, 1990. (Pubitemid 20353019)
    • (1990) Fernstrom Foundation Series , vol.14 , pp. 197-220
    • Blasberg, R.G.1    Groothuis, D.2    Molnar, P.3
  • 7
    • 0025615466 scopus 로고
    • Influence of radiation on the blood-brain barrier and optimum time of chemotherapy
    • Qin DX, Zheng R, Tang J, Li JX and Hu Y: Influence of radiation on the blood-brain barrier and optimum time of chemotherapy. Int J Radiat Oncol Biol Phys 19: 1507-1510, 1990.
    • (1990) Int J Radiat Oncol Biol Phys , vol.19 , pp. 1507-1510
    • Qin, D.X.1    Zheng, R.2    Tang, J.3    Li, J.X.4    Hu, Y.5
  • 8
    • 0030477277 scopus 로고    scopus 로고
    • The role of chemotherapy in recurrent malignant gliomas: An overview
    • Brandes AA and Fiorentino MV: The role of chemotherapy in recurrent malignant gliomas: an overview. Cancer Invest 14: 551-559, 1996. (Pubitemid 26423517)
    • (1996) Cancer Investigation , vol.14 , Issue.6 , pp. 551-559
    • Brandes, A.A.1    Fiorentino, M.V.2
  • 10
    • 0025866115 scopus 로고
    • Primary CNS lymphoma treated with osmotic blood-brain barrier disruption: Prolonged survival and preservation of cognitive function
    • Neuwelt EA, Goldman DL, Dahlborg SA, Crossen J, Ramsey F, Roman-Goldstein S, Braziel R and Dana B: Primary CNS lymphoma treated with osmotic blood-brain barrier disruption: prolonged survival and preservation of cognitive function. J Clin Oncol 9: 1580-1590, 1991.
    • (1991) J Clin Oncol , vol.9 , pp. 1580-1590
    • Neuwelt, E.A.1    Goldman, D.L.2    Dahlborg, S.A.3    Crossen, J.4    Ramsey, F.5    Roman-Goldstein, S.6    Braziel, R.7    Dana, B.8
  • 11
    • 0032894990 scopus 로고    scopus 로고
    • Pharmacokinetics of etoposide and carboplatin in cerebrospinal fluid and plasma during hyperosmotic disruption of the blood brain barrier and intraarterial combination chemotherapy
    • Morikawa N, Mori T, Abe T, Kawashima H, Takeyama M and Hori S: Pharmacokinetics of etoposide and carboplatin in cerebrospinal fluid and plasma during hyperosmotic disruption of the blood brain barrier and intraarterial combination chemotherapy. Biol Pharm Bull 22: 428-431, 1999. (Pubitemid 29219991)
    • (1999) Biological and Pharmaceutical Bulletin , vol.22 , Issue.4 , pp. 428-431
    • Morikawa, N.1    Mori, T.2    Abe, T.3    Kawashima, H.4    Takeyama, M.5    Hori, S.6
  • 13
    • 0034142246 scopus 로고    scopus 로고
    • Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors
    • DOI 10.1002/(SICI)1097-0142(20000201)88:3<637::AID
    • Doolittle ND, Miner ME, Hall WA, Siegal T, Jerome E, Osztie E, McAllister LD, Bubalo JS, Kraemer DF, Fortin D, Nixon R, Muldoon LL and Neuwelt EA: Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors. Cancer 1: 637-647, 2000. (Pubitemid 30056941)
    • (2000) Cancer , vol.88 , Issue.3 , pp. 637-647
    • Doolittle, N.D.1    Miner, M.E.2    Hall, W.A.3    Siegal, T.4    Hanson, E.J.5    Osztie, E.6    McAllister, L.D.7    Bubalo, J.S.8    Kraemer, D.F.9    Fortin, D.10    Nixon, R.11    Muldoon, L.L.12    Neuwelt, E.A.13
  • 14
    • 0032037129 scopus 로고    scopus 로고
    • Blood-brain barrrier disruption for the treatment of malignant brain tumors: The National Program
    • Doolittle ND, Petrillo A, Bell S, Cummings P and Eriksen S: Blood-brain barrrier disruption for the treatment of malignant brain tumors: The National Program. J Neurosci Nurs 30: 81-90, 1998.
    • (1998) J Neurosci Nurs , vol.30 , pp. 81-90
    • Doolittle, N.D.1    Petrillo, A.2    Bell, S.3    Cummings, P.4    Eriksen, S.5
  • 16
    • 0034061487 scopus 로고    scopus 로고
    • Pharmacokinetics of carboplatin administered in combination with the bradykinin agonist Cereport (RMP-7) for the treatment of brain tumours
    • Thomas HD, Lind MJ, Ford J, Bleehen N, Calvert AH and Boddy AV: Pharmacokinetics of carboplatin administered in combination with the bradykinin agonist Cereport (RMP-7) for the treatment of brain tumors. Cancer Chemother Pharmacol 45: 284-290, 2000. (Pubitemid 30151521)
    • (2000) Cancer Chemotherapy and Pharmacology , vol.45 , Issue.4 , pp. 284-290
    • Thomas, H.D.1    Lind, M.J.2    Ford, J.3    Bleehen, N.4    Calvert, A.H.5    Boddy, A.V.6
  • 18
    • 0022192855 scopus 로고
    • 82Rb: The effect of dexamethasone and whole-brain radiation therapy
    • Jarden JO, Dhawan V, Poltorak A, Posner JB and Rottenberg DA: Positron emission tomographic measurement of blood-to-brain and blood-to-tumor transport of 82Rb: the effect of dexamethasone and whole brain radiation therapy. Ann Neurol 18: 636-646, 1985. (Pubitemid 16085157)
    • (1985) Annals of Neurology , vol.18 , Issue.6 , pp. 636-646
    • Jarden, J.O.1    Dhawan, V.2    Poltorak, A.3
  • 19
    • 0021115110 scopus 로고
    • Radiation related disturbance of blood/brain barrier during therapy of acute lymphoblastic leucaemia
    • Stephani U, Rating D, Korinthenberg R, Siemes H, Riehm H and Hanefeld F: Radiation related disturbance of blood/brain barrier during therapy of acute lymphoblastic leucaemia. Lancet 2: 1036-1037, 1983.
    • (1983) Lancet , vol.2 , pp. 1036-1037
    • Stephani, U.1    Rating, D.2    Korinthenberg, R.3    Siemes, H.4    Riehm, H.5    Hanefeld, F.6
  • 21
    • 0021932127 scopus 로고
    • Acute changes in blood-CSF barrier permselectivity to serum proteins after intrathecal methotrexate and CNS irradiation
    • DOI 10.1007/BF00313712
    • Livrea P, Trojano M, Simone IL, Zimatore GB, Logroscino GC, Pisicchio L, Lojacono G, Colella R and Ceci A: Acute changes in blood-CSF barrier permselectivity to serum proteins after intrathecal methotrexate and CNS irradiation. J Neurol 231: 336-339, 1985. (Pubitemid 15197063)
    • (1985) Journal of Neurology , vol.231 , Issue.6 , pp. 336-339
    • Livrea, P.1    Trojano, M.2    Simone, I.L.3
  • 22
    • 0023276729 scopus 로고
    • Effect of cranial irradiation on the bloodcerebrospinal fluid and blood-brain barrier
    • Ludwig R: Effect of cranial irradiation on the bloodcerebrospinal fluid and blood-brain barrier. Klin Padiatr 199: 233-238, 1987.
    • (1987) Klin Padiatr , vol.199 , pp. 233-238
    • Ludwig, R.1
  • 23
    • 0023636008 scopus 로고
    • DIE DYNAMISCHE CT ZUR VERLAUFSBEURTEILUNG BESTRAHLTER INTRAKRANIELLER TUMOREN
    • Tellkamp H and Kohler K: Dynamic CT in the follow-up assessment of irradiated intracranial tumors. Digitale Bilddiagn 7: 183-186, 1987. (Pubitemid 18040872)
    • (1987) Digitale Bilddiagnostik , vol.7 , Issue.4 , pp. 183-186
    • Tellkamp, H.1    Kohler, K.2
  • 24
    • 0023522713 scopus 로고
    • 125I interstitial radiotherapy on blood-brain barrier function in normal canine brain
    • Groothuis DR, Wright DC and Ostertag CB: The effect of 125I interstitial radiotherapy on blood-brain barrier function in normal canine brain. J Neurosurg 67: 895-902, 1987. (Pubitemid 18005537)
    • (1987) Journal of Neurosurgery , vol.67 , Issue.6 , pp. 895-902
    • Groothuis, D.R.1    Wright, D.C.2    Ostertag, C.B.3
  • 26
    • 0032246317 scopus 로고    scopus 로고
    • Radiation-Induced Blood-Brain Barrier Changes: Pathophysiological Mechanisms and Clinical Implications
    • D'Avella D, Cicciarelllo R, Angileri FF, Lucerna S, La Toirre D and Tomassello F: Radiation-induced blood brain barrier changes: pathophysiological mechanisms and clinical implications. Acta Neurochir Suppl Wien 71: 282-284, 1998. (Pubitemid 128444421)
    • (1998) Acta Neurochirurgica, Supplement , vol.1998 , Issue.SUPPL. 71 , pp. 282-284
    • D'Avella, D.1    Cicciarello, R.2    Angileri, F.F.3    Lucerna, S.4    La, T.D.5    Tomasello, F.6
  • 29
    • 0018925851 scopus 로고
    • Multiple sclerosis de novo CNS IgG synthesis. Effect of CNS irradiation
    • Tourtellotte WW, Potvin AR, Baumheffner RW, Potvin JH, Ma BI, Syndulko K and Petrovich Z: Multiple sclerosis de novo CNS IgG synthesis. Effect of CNS irradiation. Arch Neurol 37: 620-624, 1980. (Pubitemid 10018486)
    • (1980) Archives of Neurology , vol.37 , Issue.10 , pp. 620-624
    • Tourtellotte, W.W.1    Potvin, A.R.2    Baumhefner, R.W.3
  • 30
    • 0022461302 scopus 로고
    • Focal cerebral vasculitis associated with circulating immune complexes and brain irradiation
    • Groothuis DR and Mikhael MA: Focal cerebral vasculitis associated with circulating immune complexes and brain irradiation. Ann Neurol 19: 590-592, 1986. (Pubitemid 16085194)
    • (1986) Annals of Neurology , vol.19 , Issue.6 , pp. 590-592
    • Groothuis, D.R.1    Mikhael, M.A.2
  • 31
    • 0025730959 scopus 로고
    • Possible alteration of the blood-brain barrier by boron-neutron capture therapy
    • Hatanaka H, Moritani M and Camillo M: Possible alteration of the blood-brain barrier by boron-neutron capture therapy. Acta Oncol 30: 375-378, 1991.
    • (1991) Acta Oncol , vol.30 , pp. 375-378
    • Hatanaka, H.1    Moritani, M.2    Camillo, M.3
  • 32
    • 0024557283 scopus 로고
    • The effects of ionizing radiation and dexamethasone on the blood-brain-barrier and blood-tumor-barrier: implications for boron neutron capture therapy of brain tumors
    • Dorn RV, Spickard JH and Griebenow ML: The effects of ionizing radiation and dexamethasone on the blood-brain barrier and blood-tumor-barrier: implications for boron neutron capture therapy of brain tumors. Strahlenther Onkol 165: 219-221, 1989. (Pubitemid 19073431)
    • (1989) Strahlentherapie und Onkologie , vol.165 , Issue.2-3 , pp. 219-221
    • Dorn III, R.V.1    Spickard, J.H.2    Griebenow, M.L.3
  • 33
    • 0021940179 scopus 로고
    • Effect of X-irradiation on the pharmacokinetics of methotrexate in rats: Alteration of the blood-brain barrier
    • DOI 10.1016/0277-5379(85)90275-5
    • Storm AJ, van der Kogel AJ and Nooter K: Effect of X-irradiation on the pharmacokinetics of methotrexate in rats: alteration of the blood-brain barrier. Eur J Cancer Clin Oncol 21:759-764, 1985. (Pubitemid 15119338)
    • (1985) European Journal of Cancer and Clinical Oncology , vol.21 , Issue.6 , pp. 759-764
    • Storm, A.J.1    Van Der, K.A.J.2    Nooter, K.3
  • 35
    • 0035889349 scopus 로고    scopus 로고
    • Improved efficacy of chemotherapy for glioblastoma by radiation-induced opening of blood-brain barrier: Clinical results
    • DOI 10.1016/S0360-3016(01)01735-7, PII S0360301601017357
    • Qin D, Ou G, Mo H, Song Y, Kang G, Hu Y and Gu X: Improved efficacy of chemotherapy for glioblastoma by radiation-induced opening of blood-brain barrier: clinical results. Int J Radiat Oncol Biol Phys 5: 959-962, 2001. (Pubitemid 33026426)
    • (2001) International Journal of Radiation Oncology Biology Physics , vol.51 , Issue.4 , pp. 959-962
    • Qin, D.1    Ou, G.2    Mo, H.3    Song, Y.4    Kang, G.5    Hu, Y.6    Gu, X.7
  • 36
    • 0026527243 scopus 로고
    • Neuropsychologic assessment outcomes of non-acquired immunodeficiency syndrome patients with primary central nervous system lymphoma before and after blood-brain barrier disruption chemotherapy
    • Crossen JR, Goldman DL, Dahlborg SA and Neuwelt EA: Neuropsychologic assessment outcomes of non-acquired immunodeficiency syndrome patients with primary central nervous system lymphoma before and after blood-brain barrier disruption chemotherapy. Neurosurgery 30: 23-29, 1992.
    • (1992) Neurosurgery , vol.30 , pp. 23-29
    • Crossen, J.R.1    Goldman, D.L.2    Dahlborg, S.A.3    Neuwelt, E.A.4
  • 37
    • 0033974507 scopus 로고    scopus 로고
    • Osmotic opening of the blood-brain barrier: Principles, mechanism, and therapeutic applications
    • Rapaport SI: Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications. Cell Mol Neurobiol 20: 217-230, 2000.
    • (2000) Cell Mol Neurobiol , vol.20 , pp. 217-230
    • Rapaport, S.I.1
  • 38
    • 0032776321 scopus 로고    scopus 로고
    • Phase II studies of RMP-7 and carboplatin in the treatment of recurrent high grade glioma
    • RMP-7 European Study Group
    • Gregor A, Lind M, Newman H, Grant R, Hadley DM, Barton T and Osborn C: Phase II studies of RMP-7 and carboplatin in the treatment of recurrent high grade glioma. RMP-7 European Study Group. J Neurooncol 44: 137-145, 1999.
    • (1999) J Neurooncol , vol.44 , pp. 137-145
    • Gregor, A.1    Lind, M.2    Newman, H.3    Grant, R.4    Hadley, D.M.5    Barton, T.6    Osborn, C.7
  • 39
    • 0035889378 scopus 로고    scopus 로고
    • Efficacy after sequencing of brain radiotherapy and enhanced antibody targeted chemotherapy delivery in a rodent human lung cancer brain xenograft model
    • DOI 10.1016/S0360-3016(01)01743-6, PII S0360301601017436
    • Remsen LG, Marquez C, Garcia R, Thrun LA and Neuwelt EA: Efficacy after sequencing of brain radiotherapy and enhanced antibody targeted chemotherapy delivery in a rodent human lung cancer brain xenograft model. Int J Radiat Oncol Biol Phys 15: 1045-1049,2001. (Pubitemid 33026436)
    • (2001) International Journal of Radiation Oncology Biology Physics , vol.51 , Issue.4 , pp. 1045-1049
    • Remsen, L.G.1    Marquez, C.2    Garcia, R.3    Thrun, L.A.4    Neuwelt, E.A.5
  • 41
    • 17744368252 scopus 로고    scopus 로고
    • Improved survival after boron neutron capture therapy of brain tumors by Cereport-mediated blood-brain barrier modulation to enhance delivery of boronophenylalanine
    • Yang W, Barth RF, Bartus RT, Rotaru JH, Moeschberger ML, Ferketich AK, Nawrocky MM, Coderre JA and Goodman JH: Improved survival after boron neutron capture therapy of brain tumors by Cereport-mediated blood-brain barrier modulation to enhance delivery of boronophenylalanine. Neurosurgery 47: 189-197, 2000.
    • (2000) Neurosurgery , vol.47 , pp. 189-197
    • Yang, W.1    Barth, R.F.2    Bartus, R.T.3    Rotaru, J.H.4    Moeschberger, M.L.5    Ferketich, A.K.6    Nawrocky, M.M.7    Coderre, J.A.8    Goodman, J.H.9
  • 43
    • 0032699828 scopus 로고    scopus 로고
    • Late radiation injury to the temporal lobes: Morphologic evaluation at MR imaging
    • Chan YL, Leung SF, King AD, Choi PH and Metreweli C: Late radiation injury to the temporal lobes: morphologic evaluation at MR imaging. Radiology 213: 800-807, 1999.
    • (1999) Radiology , vol.213 , pp. 800-807
    • Chan, Y.L.1    Leung, S.F.2    King, A.D.3    Choi, P.H.4    Metreweli, C.5
  • 44
    • 0031755577 scopus 로고    scopus 로고
    • Malignant glioma: Who benefits from adjuvant chemotherapy?
    • DOI 10.1002/ana.410440418
    • DeAngelis LM, Burger PC, Green SB and Cairncross JG: Malignant glioma: who benefits from adjuvant chemotherapy? Ann Neurol 44: 691-695, 1998. (Pubitemid 28477860)
    • (1998) Annals of Neurology , vol.44 , Issue.4 , pp. 691-695
    • DeAngelis, L.M.1    Burger, P.C.2    Green, S.B.3    Cairncross, J.G.4
  • 46
    • 0028899922 scopus 로고
    • Prophylactic cranial irradiation in limited stage small cell lung cancer
    • Liengswangwong V and Bonner JA: Prophylactic cranial irradiation in limited stage small cell lung cancer. Cancer 75: 1302-1309, 1995.
    • (1995) Cancer , vol.75 , pp. 1302-1309
    • Liengswangwong, V.1    Bonner, J.A.2
  • 51
    • 0027240060 scopus 로고
    • Lack of complications in long-term survivors after treatment with Fluosol(R) and oxygen as an adjuvant to radiation therapy for high-grade brain tumors
    • Evans RG, Kimler BF, Morantz RA and Batnitzky S: Lack of complications in long-term survivors after treatment with Fluosol and oxygen as an adjuvant to radiation therapy for high-grade brain tumors. Int J Radiat Oncol Biol Phys 26: 649-652, 1993. (Pubitemid 23220164)
    • (1993) International Journal of Radiation Oncology Biology Physics , vol.26 , Issue.4 , pp. 649-652
    • Evans, R.G.1    Kimler, B.F.2    Morantz, R.A.3    Batnitzky, S.4
  • 54
    • 0028356814 scopus 로고
    • Neurobehavioral sequelae of cranial irradiation in adults: A review of radiation-induced encephalopathy
    • Crossen JR, Garwood D, Glatstein E and Neuwelt EA: Neurobehavioral sequelae of cranial irradiation in adults: a review of radiation-induced encephalopathy. J Clin Oncol 12: 627-642, 1994. (Pubitemid 24079908)
    • (1994) Journal of Clinical Oncology , vol.12 , Issue.3 , pp. 627-642
    • Crossen, J.R.1    Garwood, D.2    Glatstein, E.3    Neuwelt, E.A.4
  • 55
    • 0028247765 scopus 로고
    • Pathophysiologic aspects of malignant brain tumors studied with positron emission tomography
    • Jarden JO: Pathophysiologic aspects of malignant brain tumors studied with positron emission tomography. Acta Neurol Scand (Suppl. 156): 1-35, 1994.
    • (1994) Acta Neurol Scand , Issue.SUPPL. 156 , pp. 1-35
    • Jarden, J.O.1
  • 56
    • 0024338963 scopus 로고
    • Radiation-induced dementia in patients cured of brain metastases
    • DeAngelis LM, Delattre JY and Posner JB: Radiation-induced dementia in patients cured of brain metastases. Neurol 39: 789-796, 1989. (Pubitemid 19150153)
    • (1989) Neurology , vol.39 , Issue.6 , pp. 789-796
    • DeAngelis, L.M.1    Delattre, J.-Y.2    Posner, J.B.3
  • 57
    • 0029242949 scopus 로고
    • Prophylactic cranial irradiation for patients with small cell lung cancer
    • Bunn PA and Kelly K: Prophylactic cranial irradiation for patients with small cell lung cancer. J Natl Cancer Inst 87: 161-162, 1995.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 161-162
    • Bunn, P.A.1    Kelly, K.2
  • 59
    • 0031852664 scopus 로고    scopus 로고
    • Malignant glioma: Should chemotherapy be overthrown by experimental treatments?
    • DOI 10.1023/A:1008267312782
    • Hosli P, Sappino AP, de Tribolet N and Dietrich PY: Malignant glioma: should chemotherapy be overthrown by experimental treatments? Ann Oncol 9: 589-600, 1998. (Pubitemid 28318190)
    • (1998) Annals of Oncology , vol.9 , Issue.6 , pp. 589-600
    • Hosli, P.1    Sappino, A.P.2    De Tribolet, N.3    Dietrich, P.Y.4
  • 60
    • 0034081472 scopus 로고    scopus 로고
    • Temozolomide in early stages of newly diagnosed malignant glioma and neoplastic meningitis
    • Friedman HS: Temozolomide in early stages of newly diagnosed malignant glioma and neoplastic meningitis. Semin Oncol 27: 35-40, 2000.
    • (2000) Semin Oncol , vol.27 , pp. 35-40
    • Friedman, H.S.1
  • 61
    • 0034823436 scopus 로고    scopus 로고
    • New approaches for temozolomide therapy: Use in newly diagnosed glioma
    • Stupp R and Newlands E: New approaches for temozolomide therapy: use in newly diagnosed glioma. Semin Oncol 28 (Suppl. 13): 19-23,2001. (Pubitemid 32879942)
    • (2001) Seminars in Oncology , vol.28 , Issue.4 SUPPL. 13 , pp. 19-23
    • Stupp, R.1    Newlands, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.