Pilocarpine-induced epileptogenesis in the rat: Impact of initial duration of status epilepticus on electrophysiological and neuropathological alterations

Epilepsy Research

Volumn 51, Issue 1-2, 2002, Pages 93-107

  Klitgaard, Henrik ^a   Matagne, Alain ^a   Vanneste Goemaere, Jocelyne ^a   Margineanu, Doru Georg ^a  

^a UCB PHARMA   (Belgium)

Author keywords

Epileptogenesis; Hippocampal field potentials; Pilocarpine; Rat; Spontaneous seizures; Status epilepticus

Indexed keywords

ANTICONVULSIVE AGENT; DIAZEPAM; PILOCARPINE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; BRAIN INJURY; BRAIN NECROSIS; CONTROLLED STUDY; DISEASE DURATION; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; EPILEPTIC STATE; EPILEPTOGENESIS; HIPPOCAMPUS; MALE; NEUROPATHOLOGY; NONHUMAN; OLFACTORY CORTEX; PRIORITY JOURNAL; RAT; SEIZURE; SPIKE; THALAMUS; TIME; WEIGHT GAIN;

ANIMALS; BODY WEIGHT; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; ELECTROPHYSIOLOGY; HIPPOCAMPUS; MALE; MEMBRANE POTENTIALS; MUSCARINIC AGONISTS; OLFACTORY PATHWAYS; PILOCARPINE; RATS; RATS, SPRAGUE-DAWLEY; STATUS EPILEPTICUS;

EID: 0036752274     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(02)00099-2     Document Type: Article

References (15)

1. Cavalheiro E.A., Leite J.P., Bortolotto Z.A., Turski W.A., Ikonomidou C., Turski L. Long-term effect of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneously recurrent seizures. Epilepsia. 32:1991;778-782.
2. Doherty J., Dingledine R. Reduced excitatory drive onto interneurons in the dentate gyrus after status epilepticus. J. Neurosci. 21:2001;2048-2057.
3. Engel J. Clinical evidence for the progressive nature of epilepsy. Heinemann U., Engel J. Jr., Avanzini G., Meldrum B.S., Mouritzen-Dam A., Wasterlain C., Progressive Nature of Epileptogenesis (Epilepsy Res. Suppl. 12). 1996;9-20 Elsevier, Amsterdam.
4. Fariello R.G. Experimental evidence contrasting the concept of progressive epileptogenensis. Heinemann U., Engel J. Jr., Avanzini G., Meldrum B.S., Mouritzen-Dam A., Wasterlain C., Progressive Nature of Epileptogenesis (Epilepsy Res. Suppl. 12). 1996;3-8 Elsevier, Amsterdam.
5. Houser C.R., Esclapez M. Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures. Epilepsy Res. 26:1996;207-218.
6. Klitgaard H., Matagne A., Gobert J., Wülfert E. Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. Eur. J. Pharmacol. 353:1998;191-206.
7. A receptor-associated epileptiform effect of bicuculline in rat hippocampus. Br. J. Pharmacol. 122:1997;1146-1150.
8. Margineanu D.G., Niespodziany I., Wülfert E. Hippocampal slices from long-term streptozotocin-injected rats are prone to epileptiform responses. Neurosci. Lett. 252:1998;183-186.
9. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 4th ed. 1998;Academic Press, San Diego.
10. Prince D.A., Jacobs K. Inhibitory function in two models of chronic epileptogenesis. Epilepsy Res. 32:1998;83-92.
11. Racine R.J. Modification of seizure activity by electrical stimulation. II. Motro seizures. Electroencephalogr. Clin. Neurophysiol. 32:1972;295-299.
12. 2+-dependent intrinsic bursting in the rat pilocarpine model of temporal lobe epilepsy. J. Physiol. 532.1:2001;205-216.
13. Smith B.N., Dudek F.E. Short- and long-term changes in CA1 network excitability after kainate treatment in rats. J. Neurophysiol. 85:2001;1-9.
14. Turski W.A., Cavalheiro E.A., Schwarz M., Czuczwar S.J., Kleinrok Z., Turski L. Limbic seizures produced by pilocarpine in rats: a behavioural, electroencephalographic and neuropathological study. Behav. Brain Res. 9:1983;315-336.
15. Vanneste-Goemaere J., Klitgaard H., Matagne A., Margineanu D.-G. Electrophysiological and neuropathological changes resulting from pilocarpine-induced epileptogenesis in the rat: dependence on seizure duration. Epilepsia. 40:(Suppl. 7):1999;38.