Hot target on nociceptors: Perspectives, caveats and unique features

British Journal of Pharmacology

Volumn 155, Issue 8, 2008, Pages 1142-1144

  Szolcsanyi J ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

C polymodal nociceptor; Capsaicin; Lipid raft; Nocisensor; Resiniferatoxin; Sensocrine; Sensory efferent function; Somatostatin; Thermosensor; TRPV1 cation channel

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CATION CHANNEL; SOMATOSTATIN; TACHYKININ; VANILLOID RECEPTOR 1;

ANTIINFLAMMATORY ACTIVITY; CHANNEL GATING; DESENSITIZATION; DRUG RESEARCH; EFFERENT NERVE; GENE DELETION; LIPID RAFT; NERVE ENDING; NEUROGENIC INFLAMMATION; NOCICEPTIVE RECEPTOR; NONHUMAN; NOTE; PRIORITY JOURNAL; RECEPTOR POTENTIAL; SENSE ORGAN; SENSITIZATION; SIGNAL TRANSDUCTION;

ANIMALS; HUMANS; ION CHANNEL GATING; NOCICEPTORS; SIGNAL TRANSDUCTION;

EID: 57349129590     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.374     Document Type: Note

References (12)

1. Bessou P, Perl ER (1969). Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J Neurophysiol 32: 1025-1043.
2. Caterina MJ (2007). Transient receptor potential ion channels as participants in thermosensation and thermoregulation. Am J Physiol Regul Integr Comp Physiol 292: R64-R76.
3. Holzer P (2008). The pharmacological challenge to tame the transient receptor potential vanilloid-1 (TRPV1) nocisensor. Br J Pharmacol 155: 1145-1162 (this issue).
4. Lishko PV, Procko E, Jin X, Phelps ChB, Gaudet R (2007). The ankyrin repeats of TRPV1 bind multiple ligand and modulate channel sensitivity. Neuron 54: 905-918.
5. Myers BR, Bohlen ChJ, Julius D (2008). A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating. Neuron 58: 362-373.
6. Perl ER (1996). Cutaneous polymodal receptors: characteristics and plasticity. Progr Brain Res 113: 21-37.
7. Raisinghani M, Pabbidi RM, Premkumar LS (2005). Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin. J Physiol 567: 771-786.
8. Szolcsányi J (1996). Capsaicin-sensitive sensory nerve terminals with local and systemic efferent functions: facts and scopes of an unorthodox neuroregulatory mechanism. Progr Brain Res 113: 343-359.
9. Szolcsányi J (2002). Capsaicin receptors as target molecules on nociceptors for development of novel analgesic agents. In: Kéri Gy, Toth J (eds). Molecular Pathomechanisms and New Trends in Drug Research. Taylor and Francis: London, pp. 319-333.
10. Szolcsányi J, Pintér E, Helyes ZS, Oroszi G, Németh J (1998). Systemic anti-inflammatory effect induced by counter-irritation through a local release of somatostatin from nociceptors. Br J Pharmacol 125: 916-922.
11. Szolcsányi J, Pintér E, Helyes ZS (2004). Sensocrine function of capsaicin-sensitive nociceptors mediated by somatostatin regulates against inflammation and hyperalgesia. In: Handwerker HO, Brune K (eds). Hyperalgesia: Molecular Mechanisms and Clinical Implications. IASP Press: Seattle, pp 113-128.
12. Zhang X, Li L, McNaughton PA (2008). Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150. Neuron 59: 450-461.