Human stem cells for modeling neurological disorders: Accelerating the drug discovery pipeline

Journal of Cellular Biochemistry

Volumn 105, Issue 6, 2008, Pages 1361-1366

  Crook, Jeremy Micah ^a   Kobayashi, Nao Rei ^a  

^a INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

Author keywords

Disease models; Drug discovery; Human embryonic; Induced pluripotent; Neurology; Stem cells

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; NEUROTRANSMITTER;

ADULT STEM CELL; BIOLOGICAL MODEL; BLASTOCYST; BRAIN DEVELOPMENT; BRAIN NERVE CELL; CELL CULTURE; CELL ISOLATION; CELL TYPE; DRUG RESEARCH; EMBRYONIC STEM CELL; HIGH THROUGHPUT SCREENING; HUMAN; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NEUROLOGIC DISEASE; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVIEW; SOMATIC CELL; STEM CELL;

ANIMALS; CELL DIFFERENTIATION; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; NERVOUS SYSTEM DISEASES; NEUROGENESIS; PLURIPOTENT STEM CELLS; REGENERATIVE MEDICINE; STEM CELL TRANSPLANTATION; STEM CELLS;

EID: 57349129017     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21967     Document Type: Review

References (54)

1. Altman J, Das GD. 1965. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. J Comp Neurol 124:319-335.
2. Ben-Yosef D, Malcov M, Eiges R. 2008. PGD-derived human embryonic stem cell lines as a powerful tool for the study of human genetic disorders. Mol Cell Endocrinol 282:153-158.
3. Braam SR, Denning C, van den Brink S, Kats P, Hochstenbach R, Passier R, Mummery CL. 2008. Improved genetic manipulation of human embryonic stem cells. Nat Methods 5:389-392.
4. Braude P, Pickering S, Flinter F, Ogilvie CM. 2002. Preimplantation genetic diagnosis. Nat Rev Genet 3:941-953.
5. Cho KJ, Trzaska KA, Greco SJ, McArdle J, Wang FS, Ye JH, Rameshwar P. 2005. Neurons derived from human mesenchymal stem cells show synaptic transmission and can be induced to produce the neurotransmitter substance P by interleukin-1 alpha. Stem Cells 23:383-391.
6. Cho MS, Lee YE, Kim JY, Chung S, Cho YH, Kim DS, Kang SM, Lee H, Kim MH, Kim JH, Leem JW, Oh SK, Choi YM, Hwang DY, Chang JW, Kim DW. 2008. Highly efficient and large-scale generation of functional dopamine neurons from human embryonic stem cells. Proc Natl Acad Sci USA 105:3392-3397.
7. Crook JM, Peura TT, Kravets L, Bosman AG, Buzzard JJ, Horne R, Hentze H, Dunn NR, Zweigerdt R, Chua F, Upshall A, Colman A. 2007. The generation of six clinical-grade human embryonic stem cell lines. Cell Stem Cell 1:490-494.
8. Dimasi JA. 2001. Risks in new drug development: Approval success rates for investigational drugs. Clin Pharmacol Ther 69:297-307.
9. Dimos JT, Rodolfa KT, Niakan KK, Weisenthal LM, Mitsumoto H, Chung W, Croft GF, Saphier G, Leibel R, Goland R, Wichterle H, Henderson CE, Eggan K. 2008. Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 321:1218-1221.
10. Eiges R, Urbach A, Malcov M, Frumkin T, Schwartz T, Amit A, Yaron Y, Eden A, Yanuka O, Benvenisty N, Ben-Yosef D. 2007. Developmental study of fragile X syndrome using human embryonic stem cells derived from pre-implantation genetically diagnosed embryos. Cell Stem Cell 1:568-577.
11. Encinas JM, Vaahtokari A, Enikolopov G. 2006. Fluoxetine targets early progenitor cells in the adult brain. Proc Natl Acad Sci USA 103:8233-8238.
12. Fernandes KJ, Kobayashi NR, Gallagher CJ, Barnabe-Heider F, Aumont A, Kaplan DR, Miller FD. 2006. Analysis of the neurogenic potential of multi-potent skin-derived precursors. Exp Neurol 201:32-48.
13. Ferrero I, Mazzini L, Rustichelli D, Gunetti M, Mareschi K, Testa L, Nasuelli N, Oggioni GD, Fagioli F. 2008. Bone marrow mesenchymal stem cells from healthy donors and sporadic amyotrophic lateral sclerosis patients. Cell Transplant 17:255-266.
14. Jessberger S, Toni N, Clemenson GD, Jr., Ray J, Gage FH. 2008. Directed differentiation of hippocampal stem/progenitor cells in the adult brain. Nat Neurosci 11:888-893.
15. Kaitin KI. 2008. Obstacles and opportunities in new drug development. Clin Pharmacol Ther 83:210-212.
16. Kukekov VG, Laywell ED, Suslov O, Davies K, Scheffler B, Thomas LB, O'Brien TF, Kusakabe M, Steindler DA. 1999. Multipotent stem/progenitor cells with similar properties arise from two neurogenic regions of adult human brain. Exp Neurol 156:333-344.
17. Li XJ, Zhang SC. 2006. In vitro differentiation of neural precursors from human embryonic stem cells. Methods Mol Biol 331:169-177.
18. Liew CG, Draper JS, Walsh J, Moore H, Andrews PW. 2007. Transient and stable transgene expression in human embryonic stem cells. Stem Cells 25:1521-1528.
19. Lovell MA, Geiger H, Van Zant GE, Lynn BC, Markesbery WR. 2006. Isolation of neural precursor cells from Alzheimer's disease and aged control postmortem brain. Neurobiol Aging 27:909-917.
20. Low CB, Liou YC, Tang BL. 2008. Neural differentiation and potential use of stem cells from the human umbilical cord for central nervous system transplantation therapy. J Neurosci Res 86:1670-1679.
21. Mateizel I, De Temmerman N, Ullmann U, Cauffman G, Sermon K, Van de Velde H, De Rycke M, Degreef E, Devroey P, Liebaers I, Van Steirteghem A. 2006. Derivation of human embryonic stem cell lines from embryos obtained after IVF and after PGD for monogenic disorders. Hum Reprod 21:503-511.
22. Murrell W, Wetzig A, Donnellan M, Feron F, Burne T, Meedeniya A, Kesby J, Bianco J, Perry C, Silburn P, Mackay-Sim A. 2008. Olfactory mucosa is a potential source for autologous stem cell therapy for Parkinson's disease. Stem Cells 26:2183-2192.
23. Nat R, Nilbratt M, Narkilahti S, Winblad B, Hovatta O, Nordberg A. 2007. Neurogenic neuroepithelial and radial glial cells generated from six human embryonic stem cell lines in serum-free suspension and adherent cultures. Glia 55:385-399.
24. Nistor GI, Totoiu MO, Haque N, Carpenter MK, Keirstead HS. 2005. Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation. Glia 49:385-396.
25. Palmer TD, Schwartz PH, Taupin P, Kaspar B, Stein SA, Gage FH. 2001. Cell culture. Progenitor cells fromhuman brain after death. Nature 411:42-43.
26. Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, Lensch MW, Cowan C, Hochedlinger K, Daley GQ. 2008a. Disease-specific induced pluripotent stem cells. Cell 134:877-886.
27. Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW, Daley GQ. 2008b. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451:141-146.
28. Peura T, Bosman A, Chami O, Jansen RP, Texlova K, Stojanov T. 2008. Karyotypically normal and abnormal human embryonic stem cell lines derived from PGD-analyzed embryos. Cloning Stem Cells 10:203-216.
29. Phillips BW, Horne R, Lay TS, Rust WL, Teck TT, Crook JM. 2008. Attachment and growth of human embryonic stem cells on microcarriers. J Biotechnol. DOI: 10.1016/j.jbiotec.2008.07.1997.
30. Reynolds BA, Weiss S. 1992. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255:1707-1710.
31. Roisen FJ, Klueber KM, Lu CL, Hatcher LM, Dozier A, Shields CB, Maguire S. 2001. Adult human olfactory stem cells. Brain Res 890:11-22.
32. Ross JJ, Verfaillie CM. 2008. Evaluation of neural plasticity in adult stem cells. Philos Trans R Soc Lond B Biol Sci 363:199-205.
33. Roy NS, Wang S, Jiang L, Kang J, Benraiss A, Harrison-Restelli C, Fraser RA, Couldwell WT, Kawaguchi A, Okano H, Nedergaard M, Goldman SA. 2000. In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. Nat Med 6:271-277.
34. Safford KM, Hicok KC, Safford SD, Halvorsen YD, Wilkison WO, Gimble JM, Rice HE. 2002. Neurogenic differentiation of murine and human adipose-derived stromal cells. Biochem Biophys Res Commun 294:371-379.
35. Sanchez-Ramos JR, Song S, Kamath SG, Zigova T, Willing A, Cardozo-Pelaez F, Stedeford T, Chopp M, Sanberg PR. 2001. Expression of neural markers in human umbilical cord blood. Exp Neurol 171:109-115.
36. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R. 2003. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805-809.
37. Schaffler A, Buchler C. 2007. Concise review: Adipose tissue-derived stromal cells-basic and clinical implications for novel cell-based therapies. Stem Cells 25:818-827.
38. Schnabel J. 2008. Neuroscience: Standard model. Nature 454:682-685.
39. Schwartz PH, Brick DJ, Stover AE, Loring JF, Muller FJ. 2008. Differentiation of neural lineage cells from human pluripotent stem cells. Methods 45:142-158.
40. Sollano JA, Kirsch JM, Bala MV, Chambers MG, Harpole LH. 2008. The economics of drug discovery and the ultimate valuation of pharmacotherapies in the marketplace. Clin Pharmacol Ther 84:263-266.
41. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. 2007. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872.
42. Temple S. 2001. The development of neural stem cells. Nature 414:112-117.
43. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM. 1998. Embryonic stem cell lines derived from human blastocysts. Science 282:1145-1147.
44. Togel F, Westenfelder C. 2007. Adult bone marrow-derived stem cells for organ regeneration and repair. Dev Dyn 236:3321-3331.
45. Toma JG, McKenzie IA, Bagli D, Miller FD. 2005. Isolation and characterization of multipotent skin-derived precursors from human skin. Stem Cells 23:727-737.
46. Urbach A, Schuldiner M, Benvenisty N. 2004. Modeling for Lesch-Nyhan disease by gene targeting in human embryonic stem cells. Stem Cells 22:635-641.
47. Verlinsky Y, Strelchenko N, Kukharenko V, Rechitsky S, Verlinsky O, Galat V, Kuliev A. 2005. Human embryonic stem cell lines with genetic disorders. Reprod Biomed Online 10:105-110.
48. Vieyra DS, Goodell MA. 2007. Pluripotentiality and conditional transgene regulation in human embryonic stem cells expressing insulated tetracycline-ON transactivator. Stem Cells 25:2559-2566.
49. Westerlund U, Moe MC, Varghese M, Berg-Johnsen J, Ohlsson M, Langmoen IA, Svensson M. 2003. Stem cells from the adult human brain develop into functional neurons in culture. Exp Cell Res 289:378-383.
50. Winstead W, Marshall CT, Lu CL, Klueber KM, Roisen FJ. 2005. Endoscopic biopsy of human olfactory epithelium as a source of progenitor cells. Am J Rhinol 19:83-90.
51. Wislet-Gendebien S, Wautier F, Leprince P, Rogister B. 2005. Astrocytic and neuronal fate of mesenchymal stem cells expressing nestin. Brain Res Bull 68:95-102.
52. Xia X, Zhang Y, Zieth CR, Zhang SC. 2007. Transgenes delivered by lentiviral vector are suppressed in human embryonic stem cells in a promoter-dependent manner. Stem Cells Dev 16:167-176.
53. Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, Slukvin II, Thomson JA. 2007. Induced pluripotent stem cell lines derived from human somatic cells. Science 318:1917-1920.
54. Zhang Z, Wang X, Wang S. 2008. Isolation and characterization of mesenchymal stem cells derived from bone marrow of patients with Parkinson's disease. In Vitro Cell Dev Biol Anim 44:169-177.