Candidate antigens for Q fever serodiagnosis revealed by immunoscreening of a Coxiella burnetii protein microarray

Clinical and Vaccine Immunology

Volumn 15, Issue 12, 2008, Pages 1771-1779

  Beare, Paul A ^a   Chen, Chen ^b   Bouman, Timo ^b   Pablo, Jozelyn ^c   Unal, Berkay ^c   Cockrell, Diane C ^a   Brown, Wendy C ^d   Barbian, Kent D ^a   Porcella, Stephen F ^a   Samuel, James E ^b   Felgner, Philip L ^c   Heinzen, Robert A ^a,e  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d WASHINGTON STATE UNIVERSITY   (United States)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; BACTERIAL PROTEIN; PYROXYLIN; RECOMBINANT ANTIGEN;

ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; COXIELLA BURNETII; CROSS REACTION; DIAGNOSTIC TEST; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; HUMAN; IMMUNOASSAY; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN MICROARRAY; Q FEVER; SENSITIVITY AND SPECIFICITY; SERODIAGNOSIS; SERUM;

ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; CLONING, MOLECULAR; COXIELLA BURNETII; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; PROTEIN ARRAY ANALYSIS; PROTEOME; Q FEVER; RECOMBINANT PROTEINS; SENSITIVITY AND SPECIFICITY; SEROLOGIC TESTS;

EID: 57349121107     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00300-08     Document Type: Article

References (34)

1. Baehr, W., Y. X. Zhang, T. Joseph, H. Su, F. E. Nano, K. D. Everett, and H. D. Caldwell. 1988. Mapping antigenic domains expressed by Chlamydia trachomatis major outer membrane protein genes. Proc. Natl. Acad. Sci. USA 85:4000-4004.
2. Barbour, A. G., A. Jasinskas, M. A. Kayala, D. H. Davies, A. C. Steere, P. Baldi, and P. L. Felgner. 2008. A genome-wide proteome array reveals a limited set of immunogens in natural infections of humans and white-footed mice with Borrelia burgdorferi. Infect. Immun. 76:3374-3389.
3. Beare, P. A., S. F. Porcella, R. Seshadri, J. E. Samuel, and R. A. Heinzen. 2005. Preliminary assessment of genome differences between the reference Nine Mile Isolate and two human endocarditis Isolates of Coxiella burnetii. Ann. N. Y. Acad. Sci. 1063:64-67.
4. Brinkman, M. B., M. McKevitt, M. McLoughlin, C. Perez, J. Howell, G. M. Weinstock, S. J. Norris, and T. Palzkill. 2006. Reactivity of antibodies from syphilis patients to a protein array representing the Treponema pallidum proteome. J. Clin. Microbiol. 44:888-891.
5. Cockrell, D. C., P. A. Beare, E. R. Fischer, D. Howe, and R. A. Heinzen. 2008. A method for purifying obligate intracellular Coxiella burnetii that employs digitonin lysis of host cells. J. Microbiol. Methods 72:321-325.
6. Coleman, S. A., E. R. Fischer, D. C. Cockrell, D. E. Voth, D. Howe, D. J. Mead, J. E. Samuel, and R. A. Heinzen. 2007. Proteome and antigen profiling of Coxiella burnetii developmental forms. Infect. Immun. 75:290-298.
7. Davies, D. H., X. Liang, J. E. Hernandez, A. Randall, S. Hirst, Y. Mu, K. M. Romero, T. T. Nguyen, M. Kalantari-Dehaghi, S. Crotty, P. Baldi, L. P. Villarreal, and P. L. Felgner. 2005. Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery. Proc. Natl. Acad. Sci. USA 102:547-552.
8. Davies, D. H., M. M. McCausland, C. Valdez, D. Huynh, J. E. Hernandez, Y. Mu, S. Hirst, L. Villarreal, P. L. Felgner, and S. Crotty. 2005. Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice. J. Virol. 79:11724-11733.
9. de Keyzer, J., C. van der Does, and A. J. Driessen. 2003. The bacterial translocase: a dynamic protein channel complex. Cell. Mol. Life Sci. 60:2034-2052.
10. Eyles, J. E., B. Unal, M. G. Hartley, S. L. Newstead, H. Flick-Smith, J. L. Prior, P. C. Oyston, A. Randall, Y. Mu, S. Hirst, D. M. Molina, D. H. Davies, T. Milne, K. F. Griffin, P. Baldi, R. W. Titball, and P. L. Felgner. 2007. Immunodominant Francisella tularensis antigens identified using proteome microarray. Proteomics 7:2172-2183.
11. Gat, O., H. Grosfeld, N. Ariel, I. Inbar, G. Zaide, Y. Broder, A. Zvi, T. Chitlaru, Z. Altboum, D. Stein, S. Cohen, and A. Shafferman. 2006. Search for Bacillus anthracis potential vaccine candidates by a functional genomic-serologic screen. Infect. Immun. 74:3987-4001.
12. Hendrix, L. R., L. P. Mallavia, and J. E. Samuel. 1993. Cloning and sequencing of Coxiella burnetii outer membrane protein gene com1. Infect. Immun. 61:470-477.
13. Jing, L., D. H. Davies, T. M. Chong, S. Chun, C. L. McClurkan, J. Huang, B. T. Story, D. M. Molina, S. Hirst, P. L. Felgner, and D. M. Koelle. 2008. An extremely diverse CD4 response to vaccinia virus in humans is revealed by proteome-wide T-cell profiling. J. Virol. 82:7120-7134.
14. Lopez, J. E., P. A. Beare, R. A. Heinzen, J. Norimine, K. K. Lahmers, G. H. Palmer, and W. C. Brown. 2008. High-throughput identification of T-lymphocyte antigens from Anaplasma marginale expressed using in vitro transcription and translation. J. Immunol. Methods 332:129-141.
15. Marmion, B. 2007. Q fever: the long journey to control by vaccination. Med. J. Aust. 186:164-166.
16. Marmion, B. P., R. A. Ormsbee, M. Kyrkou, J. Wright, D. A. Worswick, A. A. Izzo, A. Esterman, B. Feery, and R. A. Shapiro. 1990. Vaccine prophylaxis of abattoir-associated Q fever: eight years' experience in Australian abattoirs. Epidemiol. Infect. 104:275-287.
17. Maurin, M., and D. Raoult. 1999. Q fever. Clin. Microbiol. Rev. 12:518-553.
18. Mora, M., C. Donati, D. Medini, A. Covacci, and R. Rappuoli. 2006. Microbial genomes and vaccine design: refinements to the classical reverse vaccinology approach. Curr. Opin. Microbiol. 9:532-536.
19. Pan, X., A. Luhrmann, A. Satoh, M. A. Laskowski-Arce, and C. R. Roy. 2008. Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science 320:1651-1654.
20. Regis, D. P., C. Dobano, P. Quinones-Olson, X. Liang, N. L. Graber, M. E. Stefaniak, J. J. Campo, D. J. Carucci, D. A. Roth, H. He, P. L. Felgner, and D. L. Doolan. 2008. Transcriptionally active PCR for antigen identification and vaccine development: in vitro genome-wide screening and in vivo immunogenicity. Mol. Biochem. Parasitol. 158:32-45.
21. Scola, B. L. 2002. Current laboratory diagnosis of Q fever. Semin. Pediatr. Infect. Dis. 13:257-262.
22. Seshadri, R., I. T. Paulsen, J. A. Eisen, T. D. Read, K. E. Nelson, W. C. Nelson, N. L. Ward, H. Tettelin, T. M. Davidsen, M. J. Beanan, R. T. Deboy, S. C. Daugherty, L. M. Brinkac, R. Madupu, R. J. Dodson, H. M. Khouri, K. H. Lee, H. A. Carty, D. Scanlan, R. A. Heinzen, H. A. Thompson, J. E. Samuel, C. M. Fraser, and J. F. Heidelberg. 2003. Complete genome sequence of the Q-fever pathogen Coxiella burnetii. Proc. Natl. Acad. Sci. USA 100:5455-5460.
23. Shannon, J. G., and R. A. Heinzen. 2007. Infection of human monocytederived macrophages with Coxiella burnetii. Methods Mol. Biol. 431:189-200.
24. Sharma, J., Y. Zhong, F. Dong, J. M. Piper, G. Wang, and G. Zhong. 2006. Profiling of human antibody responses to Chlamydia trachomatis urogenital tract infection using microplates arrayed with 156 chlamydial fusion proteins. Infect. Immun. 74:1490-1499.
25. Sundaresh, S., A. Randall, B. Unal, J. M. Petersen, J. T. Belisle, M. G. Hartley, M. Duffield, R. W. Titball, D. H. Davies, P. L. Felgner, and P. Baldi. 2007. From protein microarrays to diagnostic antigen discovery: a study of the pathogen Francisella tularensis. Bioinformatics 23:i508-i518.
26. Teixeira-Gomes, A. P., A. Cloeckaert, G. Bezard, R. A. Bowden, G. Dubray, and M. S. Zygmunt. 1997. Identification and characterization of Brucella ovis immunogenic proteins using two-dimensional electrophoresis and immunoblotting. Electrophoresis 18:1491-1497.
27. Varghees, S., K. Kiss, G. Frans, O. Braha, and J. E. Samuel. 2002. Cloning and porin activity of the major outer membrane protein P1 from Coxiella burnetii. Infect. Immun. 70:6741-6750.
28. Vemulapalli, R., A. J. Duncan, S. M. Boyle, N. Sriranganathan, T. E. Toth, and G. G. Schurig. 1998. Cloning and sequencing of yajC and secD homologs of Brucella abortus and demonstration of immune responses to YajC in mice vaccinated with B. abortus RB51. Infect. Immun. 66:5684-5691.
29. Vogel, J. P. 2004. Turning a tiger into a house cat: using Legionella pneumophila to study Coxiella burnetii. Trends Microbiol. 12:103-105.
30. Voland, P., D. L. Weeks, D. Vaira, C. Prinz, and G. Sachs. 2002. Specific identification of three low molecular weight membrane-associated antigens of Helicobacter pylori. Aliment. Pharmacol. Ther. 16:533-544.
31. Williams, J. C., T. A. Hoover, D. M. Waag, N. Banerjee-Bhatnagar, C. R. Bolt, and G. H. Scott. 1990. Antigenic structure of Coxiella burnetii: a comparison of lipopolysaccharide and protein antigens as vaccines against Q fever. Ann. N. Y. Acad. Sci. 590:370-380.
32. Zhang, G., K. Kiss, R. Seshadri, L. R. Hendrix, and J. E. Samuel. 2004. Identification and cloning of immunodominant antigens of Coxiella burnetii. Infect. Immun. 72:844-852.
33. Zhang, G., and J. E. Samuel. 2004. Vaccines against Coxiella infection. Expert Rev. Vaccines 3:577-584.
34. Zhang, Y. X., N. Zhi, S. R. Yu, Q. J. Li, G. Q. Yu, and X. Zhang. 1994. Protective immunity induced by 67 K outer membrane protein of phase I Coxiella burnetii in mice and guinea pigs. Acta Virol. 38:327-332.