Transcriptionally active PCR for antigen identification and vaccine development: In vitro genome-wide screening and in vivo immunogenicity

Molecular and Biochemical Parasitology

Volumn 158, Issue 1, 2008, Pages 32-45

  Regis, David P ^a   Dobaño, Carlota ^a,b   Quiñones Olson, Paola ^a,b   Liang, Xiaowu ^c   Graber, Norma L ^a,b   Stefaniak, Maureen E ^a,b   Campo, Joseph J ^a,b   Carucci, Daniel J ^a   Roth, David A ^c   He, Huaping ^c   Felgner, Philip L ^c   Doolan, Denise L ^a,d  

^a NAVAL MEDICAL RESEARCH CENTER   (United States)

^b HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

^c Genlantis Inc   (United States)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Antigen; Genome; Malaria; PCR; Plasmodium; Screening

Indexed keywords

AMA1 ANTIGEN; CSP ANTIGEN; DNA VACCINE; EBA175 RII ANTIGEN; EXP1 ANTIGEN; GENOMIC DNA; HEP17 ANTIGEN; MSP1 ANTIGEN; PARASITE ANTIGEN; PLASMID DNA; PLASMID VECTOR; SSP2 ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN DETECTION; ANTIGEN SPECIFICITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DNA SUPERCOILING; DRUG EFFICACY; ENZYME LINKED IMMUNOSPOT ASSAY; EVIDENCE BASED MEDICINE; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENT ANTIBODY TECHNIQUE; GENE AMPLIFICATION; GENE SEQUENCE; GENETIC DATABASE; GENETIC TRANSCRIPTION; GENOME; HIGH THROUGHPUT SCREENING; HUMAN; IMMUNIZATION; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MALARIA; MOUSE; NONHUMAN; OPEN READING FRAME; PLASMODIUM YOELII; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROVOCATION TEST; SPOROZOITE; VACCINE PRODUCTION;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; CYTOKINES; FEMALE; MALARIA VACCINES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; POLYMERASE CHAIN REACTION; SPLEEN; T-LYMPHOCYTES; VACCINES, DNA;

MUS; PLASMODIUM FALCIPARUM; PLASMODIUM PARASITES; PLASMODIUM YOELII;

EID: 38649119184     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2007.11.009     Document Type: Article

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