COX-2 promoter polymorphisms and the association with prostate cancer risk in South African men

Carcinogenesis

Volumn 29, Issue 12, 2008, Pages 2347-2350

  Fernandez, Pedro ^a   De Beer, Pieter M ^a,b   Van der Merwe, Lize ^c,d   Heyns, Chris F ^a,b  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b STELLENBOSCH UNIVERSITY   (South Africa)

^c SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^d UNIVERSITY OF THE WESTERN CAPE   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; CYCLOOXYGENASE 2; CYTIDINE; GUANOSINE; THYMIDINE;

ADULT; AGE; AGED; ARTICLE; CANCER RISK; CARCINOGENESIS; CASE CONTROL STUDY; CONTROLLED STUDY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; PROSTATECTOMY; SINGLE NUCLEOTIDE POLYMORPHISM; SOUTH AFRICA; TRANSURETHRAL RESECTION;

AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CYCLOOXYGENASE 2; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; PROSTATIC NEOPLASMS; RISK FACTORS; SOUTH AFRICA;

EID: 57349109883     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgn245     Document Type: Article

References (33)

1. Smith,W.L. et al. (2000) Cyclooxygenases: Structural, cellular, and molecular biology. Annu. Rev. Biochem., 69, 145-182.
2. Tsujii,M. et al. (1995) Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell, 83, 493-501.
3. Masferrer,J.L. et al. (2000) Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. Cancer Res., 60, 1306-1311.
4. O'Byrne,K.J. et al. (2001) Chronic immune activation and inflammation as the cause of malignancy. Br. J. Cancer, 85, 473-483.
5. Half,E. et al. (2002) Cyclooxygenase-2 expression in human breast cancers and adjacent ductal carcinoma in situ. Cancer Res., 62 1676-1681.
6. Shariat,S.F. et al. (2003) Cyclooxygenase-2 is highly expressed in carcinoma in situ and T1 transitional cell carcinoma of the bladder. J. Urol., 169, 938-942.
7. Yu,H.P. et al. (2003) Cyclooxygenase-2 expression in squamous dysplasia and squamous cell carcinoma of the esophagus. Cancer Lett. 198, 193-201.
8. Gupta,S. et al. (2000) Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma. Prostate, 42, 73-78.
9. Kirschenbaum,A. et al. (2000) Expression of cyclooxygenase-1 and cyclooxygenase-2 in the human prostate. Urology, 56, 671-676.
10. Zha,S. et al. (2001) Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma. Cancer Res., 61, 8617-8623.
11. Fritsche,E. et al. (2001) Functional characterization of cyclooxygenase-2 polymorphisms. J. Pharmacol. Exp. Ther., 299 468-476.
12. Campa,D. et al. (2004) Association of a common polymorphism in the cyclooxygenase 2 gene with risk of non-small cell lung cancer. Carcinogenesis, 25, 229-235.
13. Cox,D.G. et al. (2004) Polymorphisms in prostaglandin synthase 2/ cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer. Br. J. Cancer, 91, 339-343.
14. Panguluri,R.C. et al. (2004) COX-2 gene promoter haplotypes and prostate cancer risk. Carcinogenesis, 25, 961-966.
15. Shahedi,K. et al. (2006) Genetic variation in the COX-2 gene and the association with prostate cancer risk. Int. J. Cancer, 119 668-672.
16. Cheng,I. et al. (2007) COX2 genetic variation, NSAIDs, and advanced prostate cancer risk. Br. J. Cancer, 97, 557-561.
17. Danforth,K.N. et al. (2008) Polymorphic variants in PTGS2 and prostate cancer risk: Results from two large nested case-control studies. Carcinogenesis, 29, 568-572.
18. Nurse,G.T. et al. (1985) The growth of hybrid communities. In Harrison, G.A. (ed.) The Peoples of Southern Africa and Their Affinities. Clarendon Press, Oxford, UK, pp. 219-224.
19. Cardon,L.R. et al. (2003) Population stratification and spurious allelic association. Lancet, 361, 598-604.
20. Schaid,D.J. et al. (2002) Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am. J. Hum.Genet., 70, 425-434.
21. Barreiro,L.B. et al. (2006) Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis. PLoS Med., 3, e20.
22. Ziegler,A. et al. (2006) Association analysis in unrelated people. In A Statistical Approach to Genetic Epidemiology: Concepts and Applications. Wiley-VCH, Weinheim, Germany, pp. 210-213.
23. Bacanu,S.A. et al. (2000) The power of genomic control. Am. J. Hum. Genet., 66, 1933-1944.
24. Tazawa,R. et al. (1994) Characterization of the genomic structure, chromosomal location and promoter of human prostaglandin H synthase-2 gene. Biochem. Biophys. Res. Commun., 203, 190-199.
25. Uotila,P. et al. (2001) Increased expression of cyclooxygenase-2 and nitric oxide synthase-2 in human prostate cancer. Urol. Res., 29, 23-28.
26. Denkert,C. et al. (2007) Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of Polo-like kinase-1. Prostate, 67, 361-369.
27. Bol,D.K. et al. (2002) Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development. Cancer Res., 62, 2516-2521.
28. Kim,Y. et al. (1998) Transcriptional regulation of cyclooxygenase-2 in mouse skin carcinoma cells. Regulatory role of CCAAT/ enhancer-binding proteins in the differential expression of cyclooxygenase-2 in normal and neoplastic tissues. J. Biol. Chem., 273, 27686-27694.
29. Callejas,N.A. et al. (2000) Regulation of cyclooxygenase 2 expression in hepatocytes by CCAAT/enhancer-binding proteins. Gastroenterology, 119, 493-501.
30. Chen,Y.S. et al. (2000) mtDNA variation in the South African Kung and Khwe-and their genetic relationships to other African populations. Am. J. Hum. Genet., 66, 1362-1383.
31. Ely,B. et al. (2006) African-American mitochondrial DNAs often match mtDNAs found in multiple African ethnic groups. BMC Biol., 4, 34.
32. Tishkoff,S.A. et al. (2002) Genetic analysis of African populations: Human evolution and complex disease. Nature Rev. Genet. 3, 611-621.
33. Heyns,C.F. et al. (2003) Problems with prostate specific antigen screening for prostate cancer in the primary healthcare setting in South Africa. BJU Int., 91, 785-788.