Oil-filled polymer microcapsules for ultrasound-mediated delivery of lipophilic drugs

Journal of Controlled Release

Volumn 133, Issue 2, 2009, Pages 109-118

  Kooiman, Klazina ^a   Böhmer, Marcel R ^b   Emmer, Marcia ^a   Vos, Hendrik J ^a   Chlon, Ceciel ^b   Shi, William T ^b   Hall, Christopher S ^b   de Winter, Suzanne H P M ^b   Schroën, Karin ^c   Versluis, Michel ^d   de Jong, Nico ^a,d,e   van Wamel, Annemieke ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b PHILIPS RESEARCH LABORATORIES   (Netherlands)

^c WAGENINGEN UNIVERSITY   (Netherlands)

^d UNIVERSITY OF TWENTE   (Netherlands)

^e ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

Author keywords

Acoustic properties; Drug delivery; Lipophilic drug; Polymer shelled microcapsule; Ultrasound contrast agent

Indexed keywords

ACOUSTIC PROPERTIES; ACOUSTIC WAVES; ACOUSTICS; AGENTS; DRUG DELIVERY; EMULSIFICATION; LACTIC ACID; MEDICAL IMAGING; OIL WELL PRODUCTION; ORGANIC ACIDS; PARAFFINS; POLYMERS; ULTRASONIC TRANSMISSION; ULTRASONICS;

ACOUSTIC ACTIVATIONS; ACOUSTIC PRESSURES; AND MODELS; CHARACTERISATION; CURRENT LIMITATIONS; DRUG LOADS; DRUG RELEASES; FILLED POLYMERS; GASEOUS PHASE; HEXADECANE; LIPOPHILIC DRUG; LIPOPHILIC DRUGS; LOCAL DELIVERIES; LOCAL DRUG DELIVERIES; MEMBRANE EMULSIFICATIONS; MICROCAPSULES; POLIES (L-LACTIC ACID); ULTRASOUND CONTRAST AGENT; ULTRASOUND CONTRAST AGENTS; ULTRASOUND IMAGES;

ULTRASONIC IMAGING;

DRUG CARRIER; ECHO CONTRAST MEDIUM; HEXADECANE; POLYLACTIC ACID; POLYMER;

ACOUSTICS; ARTICLE; B SCAN; DRUG DELIVERY SYSTEM; EMULSION; ENCAPSULATION; MICROCAPSULE; PRIORITY JOURNAL;

ALKANES; CALORIMETRY, DIFFERENTIAL SCANNING; CAPSULES; CYCLODECANES; DRUG DELIVERY SYSTEMS; FLUOROCARBONS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GASES; HYDROPHOBICITY; LACTIC ACID; MICROSCOPY, ELECTRON; PARTICLE SIZE; PHANTOMS, IMAGING; PHARMACEUTICAL PREPARATIONS; POLYMERS; POLYVINYL ALCOHOL; SURFACE PROPERTIES; ULTRASONICS; ULTRASONOGRAPHY;

EID: 57349105134     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.09.085     Document Type: Article

References (48)

1. Pitt W.G., Husseini G.A., and Staples B.J. Ultrasonic drug delivery - a general review. Expert Opin. Drug Deliv. 1 1 (2004) 37-56
2. Klibanov A.L. Microbubble contrast agents: targeted ultrasound imaging and ultrasound-assisted drug-delivery applications. Invest. Radiol. 41 3 (2006) 354-362
3. Dijkmans P.A., Juffermans L.J., Musters R.J., van Wamel A., ten Cate F.J., van Gilst W., Visser C.A., de Jong N., and Kamp O. Microbubbles and ultrasound: from diagnosis to therapy. Eur. J. Echocardiog. 5 4 (2004) 245-256
4. Unger E.C., Matsunaga T.O., McCreery T., Schumann P., Sweitzer R., and Quigley R. Therapeutic applications of microbubbles. Eur. J. Radiol. 42 2 (2002) 160-168
5. Juffermans L.J., Dijkmans P.A., Musters R.J., van Wamel A., Bouakaz A., ten Cate F.J., Deelman L., Visser C.A., de Jong N., and Kamp O. Local drug and gene delivery through microbubbles and ultrasound: a safe and efficient alternative for viral vectors?. Neth. Heart J. 12 9 (2004) 398-403
6. Liu Y., Miyoshi H., and Nakamura M. Encapsulated ultrasound microbubbles: therapeutic application in drug/gene delivery. J. Control. Release 114 1 (2006) 89-99
7. Ferrara K., Pollard R., and Borden M. Ultrasound microbubble contrast agents: fundamentals and application to gene and drug delivery. Annu. Rev. Biomed. Eng. 9 (2007) 415-447
8. Postema M., and Schmitz G. Bubble dynamics involved in ultrasonic imaging. Expert Rev. Mol. Diagn. 6 3 (2006) 493-502
9. Muro S., Koval M., and Muzykantov V. Endothelial endocytic pathways: gates for vascular drug delivery. Curr. Vasc. Pharmacol. 2 3 (2004) 281-299
10. Kavanagh C.A., Rochev Y.A., Gallagher W.M., Dawson K.A., and Keenan A.K. Local drug delivery in restenosis injury: thermoresponsive co-polymers as potential drug delivery systems. Pharmacol. Ther. 102 1 (2004) 1-15
11. Torchilin V.P. Drug targeting. Eur. J. Pharm. Sci. 11 Suppl 2 (2000) S81-S91
12. Reddy L.H. Drug delivery to tumours: recent strategies. J. Pharm. Pharmacol. 57 10 (2005) 1231-1242
13. van Wamel A., Kooiman K., Harteveld M., Emmer M., ten Cate F.J., Versluis M., and de Jong N. Vibrating microbubbles poking individual cells: drug transfer into cells via sonoporation. J. Control. Release 112 2 (2006) 149-155
14. Chappell J.C., and Price R.J. Targeted therapeutic applications of acoustically active microspheres in the microcirculation. Microcirculation 13 1 (2006) 57-70
15. Bekeredjian R., Grayburn P.A., and Shohet R.V. Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine. J. Am. Coll. Cardiol. 45 3 (2005) 329-335
16. Unger E.C., McCreery T.P., Sweitzer R.H., Caldwell V.E., and Wu Y. Acoustically active lipospheres containing paclitaxel: a new therapeutic ultrasound contrast agent. Invest. Radiol. 33 12 (1998) 886-892
17. Tartis M.S., McCallan J., Lum A.F.H., LaBell R., Stieger S.M., Matsunaga T.O., and Ferrara K.W. Therapeutic effects of paclitaxel-containing ultrasound contrast agents. Ultrasound Med. Biol. 32 11 (2006) 1771-1780
18. Böhmer M.R., Schroeders R., Steenbakkers J.A.M., de Winter S.H.P.M., Duineveld P.A., Lub J., Nijssen W.P.M., Pikkemaat J.A., and Stapert H.R. Preparation of monodisperse polymer particles and capsules by ink-jet printing. Colloids Surf., A Physicochem. Eng. Asp. 289 (2006) 96-104
19. Lee W.K., Losito I., Gardella J.A., and Hicks W.L. Synthesis and surface properties of fluorocarbon end-capped biodegradable polyesters. Macromolecules 34 9 (2001) 3000-3006
20. Bloedow D.C., and Hayton W.L. Effects of lipids on bioavailability of sulfisoxazole acetyl, dicumarol, and griseofulvin in rats. J. Pharm. Sci. 65 3 (1976) 328-334
21. Dowding P.J., Atkin R., Vincent B., and Bouillot P. Oil core/polymer shell microcapsules by internal phase separation from emulsion droplets. II: controlling the release profile of active molecules. Langmuir 21 12 (2005) 5278-5284
22. Ma G.H. Preparation of uniform poly(lactide) microspheres by employing the Shirasu Porous Glass (SPG) emulsification technique. Colloids Surf., A Physicochem. Eng. Asp. 153 (1999) 383-394
23. Romero-Cano M.S., and Vincent B. Controlled release of 4-nitroanisole from poly(lactic acid) nanoparticles. J. Control. Release 82 1 (2002) 127-135
24. Shi W.T., Bohmer M., van Wamel A., Celebi M., Klibanov A.L., Chin C.T., Chlon C., Emmer M., Kooiman K., de Jong N., and Hall C.S. Ultrasound therapy with drug loaded microcapsules. IEEE Ultrasonics Symposium Proceedings (2007) 773-776
25. Nijsen J.F., van Steenbergen M.J., Kooijman H., Talsma H., Kroon-Batenburg L.M., van De Weert M., van Rijk P.P., De Witte A., Van Schip A.D., and Hennink W.E. Characterization of poly(l-lactic acid) microspheres loaded with holmium acetylacetonate. Biomaterials 22 22 (2001) 3073-3081
26. Nijsen J.F., van Het Schip A.D., van Steenbergen M.J., Zielhuis S.W., Kroon-Batenburg L.M., van de Weert M., van Rijk P.P., and Hennink W.E. Influence of neutron irradiation on holmium acetylacetonate loaded poly(l-lactic acid) microspheres. Biomaterials 23 8 (2002) 1831-1839
27. Solarski S., Ferreira M., and Devaux E. Characterization of the thermal properties of PLA fibers by modulated differential scanning calorimetry. Polymer 46 25 (2005) 11187-11192
28. Bjerknes K., Sontum P.C., Smistad G., and Agerkvist I. Preparation of polymeric microbubbles: formulation studies and product characterisation. Int. J. Pharm. 158 2 (1997) 129-136
29. Schneider M., Bussat P., Barrau M.B., Arditi M., Yan F., and Hybl E. Polymeric microballoons as ultrasound contrast agents - physical and ultrasonic properties compared with sonicated albumin. Invest. Radiol. 27 2 (1992) 134-139
30. de Jong N., Hoff L., Skotland T., and Bom N. Absorption and scatter of encapsulated gas filled microspheres: theoretical considerations and some measurements. Ultrasonics 30 2 (1992) 95-103
31. Shi W., Bohmer M., de Winter S., Steenbakkers J., Emmer M., van Wamel A., de Jong N., and Hall C.S. Ultrasonic characterization of novel monodispersed contrast agents. IEEE Ultrasonics Symposium Proceedings (2006) 301-304
32. Chin C.T., Lancee C., Borsboom J., Mastik F., Frijlink M., de Jong N., Versluis M., and Lohse D. Brandaris 128: a 25 million frames per second digital camera with 128 highly sensitive frames. Rev. Sci. Instrum. 74 12 (2003) 5026-5034
33. Emmer M., van Wamel A., Goertz D.E., and de Jong N. The onset of microbubble vibration. Ultrasound Med. Biol. 33 6 (2007) 941-949
34. van der Meer S.M., Dollet B., Voormolen M.M., Chin C.T., Bouakaz A., de Jong N., Versluis M., and Lohse D. Microbubble spectroscopy of ultrasound contrast agents. J. Acoust. Soc. Am. 121 1 (2007) 648-656
35. Emmer M., Vos H.J., van Wamel A., Goertz D.E., Versluis M., and de Jong N. Clinical relevance of pressure-dependent scattering at low acoustic pressures. Ultrasonics 47 1-4 (2007) 74-77
36. Hoff L., Sontum P.C., and Hovem J.M. Oscillations of polymeric microbubbles: effect of the encapsulating shell. J. Acoust. Soc. Am. 107 4 (2000) 2272-2280
37. Leighton T.G. The acoustic bubble (1994), Academic Press, London
38. May D.J., Allen J.S., and Ferrara K.W. Dynamics and fragmentation of thick-shelled microbubbles. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 49 10 (2002) 1400-1410
39. Meltzer R.S., Tickner E.G., and Popp R.L. Why do the lungs clear ultrasonic contrast?. Ultrasound Med. Biol. 6 3 (1980) 263-269
40. Barnett S.B., Ter Haar G.R., Ziskin M.C., Rott H.D., Duck F.A., and Maeda K. International recommendations and guidelines for the safe use of diagnostic ultrasound in medicine. Ultrasound Med. Biol. 26 3 (2000) 355-366
41. Shortencarier M.J., Dayton P.A., Bloch S.H., Schumann P.A., Matsunaga T.O., and Ferrara K.W. A method for radiation-force localized drug delivery using gas-filled lipospheres. IEEE Trans. Ultrason. Ferroelectr. Freq. Control 51 7 (2004) 822-831
42. Seemann S., Hauff P., Schultze-Mosgau M., Lehmann C., and Reszka R. Pharmaceutical evaluation of gas-filled microparticles as gene delivery system. Pharm. Res. 19 3 (2002) 250-257
43. Bloch S.H., Wan M., Dayton P.A., and Ferrara K. Optical observation of lipid- and polymer-shelled ultrasound microbubble contrast agents. Appl. Phys. Lett. 84 4 (2004) 631-633
44. Bevan P.D., Karshafian R., Tickner E.G., and Burns P.N. Quantitative measurement of ultrasound disruption of polymer-shelled microbubbles. Ultrasound Med. Biol. 33 11 (2007) 1777-1786
45. Bouakaz A., Versluis M., and de Jong N. High-speed optical observations of contrast agent destruction. Ultrasound Med. Biol. 31 3 (2005) 391-399
46. Leong-Poi H., Song J., Rim S.J., Christiansen J., Kaul S., and Lindner J.R. Influence of microbubble shell properties on ultrasound signal: implications for low-power perfusion imaging. J. Am. Soc. Echocardiogr. 15 10 Pt 2 (2002) 1269-1276
47. Anderson J.M., and Shive M.S. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv. Drug Deliv. Rev. 28 1 (1997) 5-24
48. Straub J.A., Chickering D.E., Hartman T.G., Gloff C.A., and Bernstein H. AI-700 pharmacokinetics, tissue distribution and exhaled elimination kinetics in rats. Int. J. Pharm. 328 1 (2007) 35-41