Protective effect of aqueous extract of Embelia ribes Burm fruits in middle cerebral artery occlusion-induced focal cerebral ischemia in rats

Indian Journal of Pharmacology

Volumn 40, Issue 5 SUPPL., 2008, Pages 215-220

  Bhandari, Uma ^a   Ansari, M ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Cerebral ischemia; Embelia ribes; Middle cerebral artery occlusion; Oxidative stress

Indexed keywords

EMBELIA RIBES EXTRACT; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LACTATE DEHYDROGENASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG; CHLORAL HYDRATE; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG DOSE COMPARISON; FRUIT; GRIP STRENGTH; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MYRSINACEAE; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; REPERFUSION INJURY; TREATMENT DURATION; BRAIN LEVEL; BRAIN TISSUE; CHEMICAL PARAMETERS; DRUG EFFECT; EMBELIA; EMBELIA RIBES; FRONTAL CORTEX; HIPPOCAMPUS; SHAM PROCEDURE; TREATMENT OUTCOME;

EID: 57349093972     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.44153     Document Type: Article

References (40)

1. Wolf PA. Epidemiology of stroke. In: Mohr JP, Choi DW, Grotta JC, Weir B, Wolf PA, editors. Stroke: pathophysiology, diagnosis, and management. 4th ed. Philadelphia: Churchill Livingstone; 2004. p. 13-34.
2. Abumiya T, Fitridge R, Mazur C, Copeland BR, Koziol JA, Tschopp JF, et al. Integrin alpha(IIb)beta(3) inhibitor preserves microvascular patency in experimental acute focal cerebral ischemia. Stroke 2000;31:1402-9.
3. Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001;21:2-14.
4. Lipton P. Ischemic cell death in brain neurons. Physiol Rev 1999;79:1431-568.
5. Traystman RJ, Kirsch JR, Koehler RC. Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J Appl Physiol 1991;71:1185-95.
6. Margaill I, Plotkine M, Lerouet D. Antioxidant strategies in the treatment of stroke. Free Radic Biol Med 2005;39:429-43.
7. Shimizu K, Rajapakse N, Horiguchi T, Payne RM, Busija DW. Protective effect of a new nonpeptidyl mimetic of SOD, M40401, against focal cerebral ischemia in the rat. Brain Res 2003;963:8-14.
8. Wang NL, Liou YL, Lin MT, Lin CL, Chang CK. Chinese herbal medicine, Shengmai San, is effective for improving circulatory shock and oxidative damage in the brain during heatstroke. J Pharmacol Sci 2005;97:253-65.
9. Kim H. Neuroprotective herbs for stroke therapy in traditional eastern medicine. Neurol Res 2005;27:287-301.
10. Bei W, Peng W, Ma Y, Xu A. NaoXinQing, an anti-stroke herbal medicine, reduces hydrogen peroxide-induced injury in NG108-15 cells. Neurosci Lett 2004;33:262-5.
11. Hordegen P, Cabaret J, Hertzberg H, Langhans W, Maurer V. In vitro screening of six anthelmintic plant products against larval Haemonchus contortus with a modified methyl-thiazolyl-tetrazolium reduction assay. J Ethnopharmacol 2006;108:85-9.
12. Gupta S, Sanyal SN, Kanwar U. Antispermatogenic effect of embelin, a plant benzoquinone, on male albino rats in vivo and in vitro. Contraception 1989;39:307-20.
13. Zutshi U, Johri RK, Atal CK. Possible interaction of potassium embelate: A putative analgesic agent, with opiate receptors. Indian J Exp Biol 1989;27:656-7.
14. Kapoor VK, Chawla AS, Kumar M, Kumar P. Anti-inflammatory agent in Indian Laboratories. Indian Drugs 1983;30:481-8.
15. Kirthikar KR, Basu BD. Indian Medicinal Plants. Lalit Mohan Basu, Vol. 2. Allahabad, India: 1987. p. 1479.
16. Bhandari U, Kanojia R, Pillai KK. Effect of ethanolic extract of Embelia ribes on dyslipidaemia in diabetic rats. Int J Exp Diab Res 2002;3:159-62.
17. Bhandari U, Jain N, Pillai KK. Further studies on antioxidant potential and protection of pancreatic β-cells by Embelia ribes in Experimental diabetes. Exp Diabetes Res 2007;2007:15803.
18. Bhandari U, Ansari MN, Islam F. Cardioprotective effect of aqueous extract of Embelia ribes Burm fruits against isoproterenol- induced myocardial infarction in albino rats. Indian J Exp Biol 2008;46:35-40.
19. Belayev L, Busto R, Zhao W, Ginsberg MD. HU-211, a novel noncompetitive N-methyl-D aspartate antagonist, improves neurological deficit and reduces infarct volume after reversible focal cerebral ischemia in the rat. Stroke 1995;26:2313-20.
20. Gupta YK. Briyal S. Animal models of cerebral ischemia for evaluation of drugs. Indian J Physiol Pharmacol 2004;48:379-94.
21. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989;20:84-91.
22. Ali A, Ahmad FJ, Pillai KK, Vohora D. Evidence of the antiepileptic potential of amiloride with neuropharmacological benefits in rodent models of epilepsy and behavior. Epilepsy Behav 2004;5:322-8.
23. Lum G, Gambino SR. A comparison of serum Vs heparinised plasma for routine chemistry tests. Am J Clin Pathol 1974;61:108-13.
24. Utley HC, Bernheim F, Hochslein P. Effect of sulfhydryl reagent on peroxidation in microsome. Arch Biochem Biophys 1967;260:521-31.
25. Islam F, Zia S, Sayeed I, Zafar KS, Ahmad AS. Selenium-induced alteration of lipids, lipid peroxidation, and thiol group in circadian rhythm centers of rat. Biol Trace Elem Res 2002;90:203-14.
26. Jollow DJ, Mitchell JR, Zampagline N, Gillette JR. Bromobenzene induced liver necrosis: Protective role of glutathione and evidence for 3,4-bromobenzene as the hepatic metabolite. Pharmacology 1974;11:151-69.
27. Wheeler CR, Salzman JA, Elsayed NM, Omaye ST, Korte DW Jr. Automated assays for superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activity. Anal Biochem 1990;184:193-9.
28. Carlberg I, Mannerviek B. Glutathione reductase levels in rat brain. J Biol Chem 1975;250:5475-80.
29. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases: The first enzymatic step in mercapturic acid formation. J Biol Chem 1974;249:7130-9.
30. Joshi CN, Jain SK, Murthy PS. An optimized triphenyltetrazolium chloride method for identification of cerebral infarcts. Brain Res Protocols 2004;13:11-7.
31. Gilgun-Sherki Y, Rosenbaum Z, Melamed E, Offen D. Antioxidant therapy in acute central nervous system injury: Current state. Pharmacol Rev 2002;54:271-84.
32. Traystman RJ, Kirsch JR, Koehler RC. Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J Appl Physiol 1991;71:1185-95.
33. Ajitha M, Rajnarayana K. Role of oxygen free radicals in Human Disease. Indian Drugs 2001;38:545-54.
34. Fukui K, Omoi NO, Hayasaka T, Shinnkai, T, Suzuki S, Abe K, et al. Cognitive impairment of rats caused by oxidative stress. Ann N Y Acad Sci 2002;959:275-84.
35. Love S. Oxidative stress in brain ischemia. Brain Pathol 1999;9:119-31.
36. Sun AY, Chen YM. Oxidative stress and neurodegenerative disorders. J Biomed Sci 1998;5:401-14.
37. Halliwell B, Gutteridge JM. Free radicals in biology and medicine. 3rd ed. New York, NY: Oxford University Press; 1999.
38. Coyle JT, Puttfarcken PO. Oxidative stress, glutamate and neurodegenera¬tive disorders. Science 1993;262:689-95.
39. Bains JS, Shaw CA. Neurodegenerative disorders in humans: The role of glutathione in oxidative stress-mediated neuronal death. Brain Res Rev 1997;25:335-8.
40. Shivakumar BR, Kolluri SV, Ravindranath V. Glutathione and protein thiol homeostasis in brain during reperfusion after cerebral ischemia. J Pharma¬col Exp Ther 1995;274:1167-73.