Natural History of Hemochromatosis: Heading Down the Up Escalator?

Gastroenterology

Volumn 135, Issue 6, 2008, Pages 1855-1857

  Adams, Paul C ^a  

^a LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; HEPCIDIN;

DEATH; EDITORIAL; GENE; GENE MUTATION; GENETIC DISORDER; GENOTYPE; HEMOCHROMATOSIS; HEMOCHROMATOSIS GENE; HOMOZYGOTE; HUMAN; IRON ABSORPTION; IRON OVERLOAD; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; PHLEBOTOMY; PRIORITY JOURNAL;

EID: 57249104885     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.11.001     Document Type: Editorial

References (27)

1. Adams P.C., and Chakrabarti S. Genotypic/phenotypic correlations in genetic hemochromatosis: evolution of diagnostic criteria. Gastroenterology 114 (1998) 319-323
2. Wojcik J., Speechley M., Kertesz A., et al. Natural history of C282Y homozygotes for haemochromatosis. Can J Gastro 16 (2002) 297-302
3. Olynyk J., Trinder D., Ramm G.A., et al. Hereditary hemochromatosis in the post-HFE era. Hepatology 48 (2008) 991-1001
4. Adams P.C., Deugnier Y., Moirand R., et al. The relationship between iron overload, clinical symptoms and age in 410 patients with genetic hemochromatosis. Hepatology 25 (1997) 162-166
5. Lazarescu A., Snively B., and Adams P.C. Phenotype variation in C282Y homozygotes for the hemochromatosis gene. Clin Gastroenterol Hepatol 3 (2005) 1043-1046
6. Phatak P., Bonkovsky H., and Kowdley K. Hereditary hemochromatosis: time for targeted screening. Ann Intern Med 149 (2008) 270-272
7. Adams P.C., and Valberg L.S. Screening blood donors for hereditary hemochromatosis: decision analysis model comparing genotyping to phenotyping. Am J Gastroenterol 94 (1999) 1593-1600
8. Adams P.C. Population screening for haemochromatosis. Gut 46 (2000) 301-303
9. Whitlock E., Garlitz B., Harris E., et al. Screening for hereditary hemochromatosis: a systematic review for the U.S. Preventative Services Task Force. Ann Intern Med 145 (2006) 209-223
10. Adams P.C. Population screening for hemochromatosis. Hepatology 29 (1999) 1324-1327
11. Gurrin L.C., Osborne N.J., Constantine C.C., et al. The natural history of serum iron indices for HFE C282Y homozygosity associated with hereditary hemochromatosis. Gastroenterology 135 (2008) 1945-1952
12. Guyader D., Jacquelinet C., Moirand R., et al. Non-invasive prediction of fibrosis in C282Y homozygous hemochromatosis. Gastroenterology 115 (1998) 929-936
13. Bozzini C., Campostrini N., Trombini P., et al. Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis. Blood Cells Mol Dis 40 (2007) 34-352
14. Piperno A., Girelli D., Nemeth E., et al. Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. Blood 110 (2007) 4096-4100
15. Adams P.C., Frei J.V., Bradley C., et al. Hepatic iron and iron absorption in hemochromatosis. Clin Invest Med 13 (1990) 256-258
16. Beutler E. Natural history of hemochromatosis. Mayo Clin Proc 79 (2004) 305-306
17. Waalen J., Felitti V.J., Gelbart T., et al. Screening for hemochromatosis by measuring ferritin levels: a more effective approach. Blood 111 (2008) 3373-3376
18. Andersen R., Tybjaerg-Hansen A., Appleyard M., et al. Hemochromatosis mutations in the general population: iron overload progression rate. Blood 103 (2004) 2914-2919
19. Olynyk J., Cullen D., Aquilia S., et al. A population-based study of the clinical expression of the hemochromatosis gene. N Engl J Med 341 (1999) 718-724
20. Pankow J., Boerwinkle E., Adams P.C., et al. HFE C282Y homozygotes have reduced low-density lipoprotein cholesterol: the Atherosclerosis Risk in Communities (ARIC) Study. Transl Res 152 (2008) 3-10
21. Beaton M., Guyader D., Deugnier Y., et al. Non-invasive prediction of cirrhosis in C282Y-linked hemochromatosis. Hepatology 36 (2002) 673-678
22. Yamashita C., and Adams P.C. Natural history of the C282Y homozygote of the hemochromatosis gene (HFE) with a normal serum ferritin level. Clin Gastroenterol Hepatol 1 (2003) 388-391
23. Adams P.C., Kertesz A.E., and Valberg L.S. Rate of iron reaccumulation following iron depletion in hereditary hemochromatosis. Implications for venesection therapy. J Clin Gastroenterol 16 (1993) 207-210
24. Beaton M., and Adams P.C. Assessment of silent liver fibrosis in hemochromatosis C282Y homozygotes with normal transaminase levels. Clin Gastroenterol Hepatol 6 (2008) 713-714
25. Adhoute X., Foucher J., Laharie D., et al. Diagnosis of liver fibrosis using FibroScan and other noninvasive methods in patients with hemochromatosis: a prospective study. Gastroenterol Clin Biol 32 (2008) 180-187
26. Falize L., Guillygomarch A., Perrin M., et al. Reversibility of hepatic fibrosis in treated genetic hemochromatosis: a study of 36 cases. Hepatology 44 (2006) 472-477
27. Powell L., Dixon J., Ramm G., et al. Screening for hemochromatosis in asymptomatic subjects with or without a family history. Arch Intern Med 166 (2006) 294-301