Reversibility of hepatic fibrosis in treated genetic hemochromatosis: A study of 36 cases

Hepatology

Volumn 44, Issue 2, 2006, Pages 472-477

  Falize, Ludivine ^a,b   Guillygomarc'h, Anne ^a   Perrin, Michele ^a   Lainé, Fabrice ^a   Guyader, Dominique ^a   Brissot, Pierre ^a   Turlin, Bruno ^a   Deugnier, Yves ^a  

^a PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^b NONE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; PROTHROMBIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DATA BASE; FEMALE; GENETIC DISORDER; HEMOCHROMATOSIS; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER CANCER; LIVER CIRRHOSIS; LIVER FIBROSIS; LIVER SURGERY; MALE; PATHOLOGIST; PHLEBOTOMY; PRIORITY JOURNAL; REMISSION; SCORING SYSTEM;

ADOLESCENT; ADULT; AGED; BIOPSY; DISEASE PROGRESSION; FOLLOW-UP STUDIES; HEMOCHROMATOSIS; HUMANS; LIVER CIRRHOSIS; MIDDLE AGED; PHLEBOTOMY; TREATMENT OUTCOME;

EID: 33747042226     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.21260     Document Type: Article

References (43)

1. Zimmermann H, Reichen J, Zimmermann A, Sagesser H, Thenisch B, Hoflin F. Reversibility of secondary biliary fibrosis by biliodigestive anastomosis in the rat. Gastroenterology 1992;103:579-589.
2. Lai CL, Chien RN, Leung NW, Chang TT, Guan R, Tai DI, et al. A one-year trial of lamivudine for chronic hepatitis B. Asia Hepatitis Lamivudine Study Group. N Engl J Med 1998;339:61-68.
3. Brook MG, Petrovic L, McDonald JA, Scheuer PJ, Thomas HC. Histological improvement after anti-viral treatment for chronic hepatitis B virus infection. J Hepatol 1989;8:218-225.
4. Yao FY, Terrault NA, Freise C, Maslow L, Bass NM. Lamivudine treatment is beneficial in patients with severely decompensated cirrhosis and actively replicating hepatitis B infection awaiting liver transplantation: a comparative study using a matched, untreated cohort. HEPATOLOGY 2001; 34:411-416.
5. Malekzadeh R, Mohamadnejad M, Rakhshani N, Nasseri-Moghaddam S, Merat S, Tavangar SM, et al. Reversibility of cirrhosis in chronic hepatitis B. Clin Gastroenterol Hepatol 2004;2:344-347.
6. Lau DT, Kleiner DE, Park Y, Di Bisceglie AM, Hoofnagle JH. Resolution of chronic delta hepatitis after 12 years of interferon alfa therapy. Gastroenterology 1999;117:1229-1233.
7. Knauer CM, Gamble CN, Monroe LS. The reversal of hemochromatotic cirrhosis by multiple phlebotomies: report of a case. Gastroenterology 1965;49:667-671.
8. Powell LW, Kerr JF. Reversal of "cirrhosis" in idiopathic haemochromatosis following long-term intensive venesection therapy. Australas Ann Med 1970;19:54-57.
9. Niederau C, Fischer R, Purschel A, Stremmel W, Haussinger D, Strohmeyer G. Long-term survival in patients with hereditary hemochromatosis. Gastroenterology 1996;110:1107-1119.
10. Kaplan MM, DeLellis RA, Wolfe HJ. Sustained biochemical and histologic remission of primary biliary cirrhosis in response to medical treatment. Ann Intern Med 1997;126:682-688.
11. Hammel P, Couvelard A, O'Toole D, Ratouis A, Sauvanet A, Flejou JF, et al. Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct. N Engl J Med 2001; 344:418-423.
12. Soyer MT, Ceballos R, Aldrete JS. Reversibility of severe hepatic damage caused by jejunoileal bypass after re-establishment of normal intestinal continuity. Surgery 1976;79:601-604.
13. Dixon JB, Bhathal PS, Hughes NR, O'Brien PE. Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss. HEPATOLOGY 2004;39:1647-1654.
14. Pradhan AM, Bhave SA, Joshi VV, Bavdekar AR, Pandit AN, Tanner MS. Reversal of Indian childhood cirrhosis by D-penicillamine therapy. J Pediatr Gastroenterol Nutr 1995;20:28-35.
15. Dufour JF, DeLellis R, Kaplan MM. Reversibility of hepatic fibrosis in autoimmune hepatitis. Ann Intern Med 1997;127:981-985.
16. Czaja AJ, Carpenter HA. Decreased fibrosis during corticosteroid therapy of autoimmune hepatitis. J Hepatol 2004;40:646-652.
17. Malekzadeh R, Mohamadnejad M, Nasseri-Moghaddam S, Rakhshani N, Tavangar SM, Sohrabpour AA, et al. Reversibility of cirrhosis in autoimmune hepatitis. Am J Med 2004;117:125-129.
18. Camma C, Giunta M, Linea C, Pagliaro L. The effect of interferon on the liver in chronic hepatitis C: a quantitative evaluation of histology by metaanalysis. J Hepatol 1997;26:1187-1199.
19. Dufour JF, DeLellis R, Kaplan MM. Regression of hepatic fibrosis in hepatitis C with long-term interferon treatment. Dig Dis Sci 1998;43: 2573-2576.
20. Sobesky R, Mathurin P, Charlotte F, Moussalli J, Olivi M, Vidaud M, et al. Modeling the impact of interferon alfa treatment on liver fibrosis progression in chronic hepatitis C: a dynamic view. The Multivirc Group. Gastroenterology 1999;116:378-386.
21. Poynard T, McHutchison J, Davis GL, Esteban-Mur R, Goodman Z, Bedossa P, et al. Impact of interferon alfa-2b and ribavirin on progression of liver fibrosis in patients with chronic hepatitis C. HEPATOLOGY 2000; 32:1131-1137.
22. Poynard T, McHutchison J, Manns M, Trepo C, Lindsay K, Goodman Z, et al. Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C. Gastroenterology 2002;122:1303-1313.
23. Pol S, Carnot F, Nalpas B, Lagneau JL, Fontaine H, Serpaggi J, et al. Reversibility of hepatitis C virus-related cirrhosis. Hum Pathol 2004;35: 107-112.
24. Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. HEPATOLOGY 1996;24:289-293.
25. Deugnier YM, Loreal O, Turlin B, Guyader D, Jouanolle H, Moirand R, et al. Liver pathology in genetic hemochromatosis: a review of 135 homozygous cases and their bioclinical correlations. Gastroenterology 1992; 102:2050-2059.
26. Desmet VJ, Roskams T. Cirrhosis reversal: a duel between dogma and myth. J Hepatol 2004;40:860-867.
27. Barry M, Sherlock S. Measurement of liver-iron concentration in needle-biopsy specimens. Lancet 1971;1:100-103.
28. Bedossa P, Dargere D, Paradis V. Sampling variability of liver fibrosis in chronic hepatitis C. HEPATOLOGY 2003;38:1449-1457.
29. Schiano TD AS, Bodian CA, Bodenheimer HC, Merati S, Thung SN, Hytiroglou P. Importance of specimen size in accurate needle liver biopsy evaluation of patients with chronic hepatitis C. Clin Gastroenterol Hepatol 2005;3:930-935.
30. Ortiz V, Berenguer M, Rayon JM, Carrasco D, Berenguer J. Contribution of obesity to hepatitis C-related fibrosis progression. Am J Gastroenterol 2002;97:2408-2414.
31. Adinolfi LE, Gambardella M, Andreana A, Tripodi MF, Utili R, Ruggiero G. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. HEPATOLOGY 2001;33:1358-1364.
32. Hourigan LF, Macdonald GA, Purdie D, Whitehall VH, Shorthouse C, Clouston A, et al. Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis. HEPATOLOGY 1999;29: 1215-1219.
33. Naveau S, Giraud V, Borotto E, Aubert A, Capron F, Chaput JC. Excess weight risk factor for alcoholic liver disease. HEPATOLOGY 1997;25:108-111.
34. Powell EE, Ali A, Clouston AD, Dixon JL, Lincoln DJ, Purdie DM, et al. Steatosis is a cofactor in liver injury in hemochromatosis. Gastroenterology 2005;129:1937-1943.
35. Powell LW, Dixon JL, Ramm GA, Purdie DM, Lincoln DJ, Anderson GJ, et al. Screening for hemochromatosis in asymptomatic subjects with or without a family history. Arch Intern Med 2006;166:294-301.
36. Desmet VJ. Comments on cirrhosis reversal. Dig Liver Dis 2005;37:909-916.
37. Wanless IR, Nakashima E, Sherman M. Regression of human cirrhosis: morphologic features and the genesis of incomplete septal cirrhosis. Arch Pathol Lab Med 2000;124:1599-1607.
38. Fellows IW, Stewart M, Jeffcoate WJ, Smith PG, Toghill PJ. Hepatocellular carcinoma in primary haemochromatosis in the absence of cirrhosis. Gut 1988;29:1603-1606.
39. Deugnier YM, Guyader D, Crantock L, Lopez JM, Turlin B, Yaouanq J, et al. Primary liver cancer in genetic hemochromatosis: a clinical, pathological, and pathogenetic study of 54 cases. Gastroenterology 1993;104:228-234.
40. Goh J, Callagy G, McEntee G, O'Keane JC, Bomford A, Crowe J. Hepatocellular carcinoma arising in the absence of cirrhosis in genetic haemochromatosis: three case reports and review of literature. Eur J Gastroenterol Hepatol 1999;11:915-919.
41. Kohler HH, Hohler T, Kusel U, Kirkpatrick CJ, Schirmacher P. Hepatocellular carcinoma in a patient with hereditary hemochromatosis and noncirrhotic liver: a case report. Pathol Res Pract 1999;195:509-513.
42. Britto MR, Thomas LA, Balaratnam N, Griffiths AP, Duane PD. Hepatocellular carcinoma arising in non-cirrhotic liver in genetic haemochromatosis. Scand J Gastroenterol 2000;35:889-893.
43. Blumberg RS, Chopra S, Ibrahim R, Crawford J, Farraye FA, Zeldis JB, et al. Primary hepatocellular carcinoma in idiopathic hemochromatosis after reversal of cirrhosis. Gastroenterology 1988;95:1399-1402.