The role of African American ethnicity and metabolism in sentinel polychlorinated biphenyl congener serum levels

Environmental Toxicology and Pharmacology

Volumn 27, Issue 1, 2009, Pages 54-61

  McGraw Sr , Joseph E ^a   Waller, Donald P ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

CYP 450; Great Lakes; Metabolism; Polychlorinated biphenyls; Pregnant African American women; Race

Indexed keywords

CYTOCHROME P450; POLYCHLORINATED BIPHENYL;

ADULT; AFRICAN AMERICAN; ARTICLE; BIOLOGICAL MONITORING; BLOOD LEVEL; CONTROLLED STUDY; ETHNICITY; FEMALE; HUMAN; HUMAN CELL; LIVER MICROSOME; METABOLISM; PREGNANCY; PRIORITY JOURNAL;

EID: 57149142497     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2008.08.008     Document Type: Article

References (71)

1. Ariyoshi N., Koga N., Oguri K., and Yoshimura H. Metabolism of 2,4,5,2′,4′,5′-hexachlorobiphenyl with liver microsomes of phenobarbital-treated dog; the possible formation of PCB 2,3-arene oxide intermediate. Xenobiotica 22 (1992) 1275-1290
2. Ariyoshi N., Ito S., Okudaira A., Mise M., Matsusue K., Yamada H., and Oguri K. Studies on PCB toxicity involving 2C subfamily cytochrome P450. Fukuoka Igaku Zasshi 86 (1995) 153-162
3. Ariyoshi N., Oguri K., Koga N., Yoshimura H., and Funae Y. Metabolism of highly persistent PCB congener, 2,4,5,2′,4′,5′-hexachlorobiphenyl, by human CYP2B6. Biochem. Biophys. Res. Commun. 212 (1995) 455-460
4. ATSDR, 2000. Toxicological Profile For Polychlorinated Biphenyls (PCBs). US Public Health Service, Agency for Toxic Substances and Disease Registry, Atlanta, GA.
5. Bergman A., Klasson-Wehler E., and Kuroki H. Selective retention of hydroxylated PCB metabolites in blood. Environ. Health Perspect. 102 (1994) 464-469
6. Burse V.W., Groce D.F., Korver M.P., McClure P.C., Head S.L., Needham L.L., Lapeza Jr. C.R., and Smrek A.L. Use of reference pools to compare the qualitative and quantitative determination of polychlorinated biphenyls by packed and capillary gas chromatography with electron capture detection. Part 1. Serum. Analyst 115 (1990) 243-251
7. Caraballo R.S., Giovino G.A., Pechacek T.F., Mowery P.D., Richter P.A., Strauss W.J., Sharp D.J., Eriksen M.P., Pirkle J.L., and Maurer K.R. Racial and ethnic differences in serum cotinine levels of cigarette smokers: Third National Health and Nutrition Examination Survey, 1988-1991. JAMA 280 (1998) 135-139
8. Chen J.J., Chen G.S., and Bunce N.J. Inhibition of CYP 1A2-dependent MROD activity in rat liver microsomes: an explanation of the hepatic sequestration of a limited subset of halogenated aromatic hydrocarbons. Environ. Toxicol. 18 (2003) 115-119
9. Chikuni O., Skare J.U., Nyazema N., and Polder A. Residues of organochlorine pesticides in human milk from mothers living in the greater Harare area of Zimbabwe. Cent. Afr. J. Med. 37 (1991) 136-141
10. Conley D., and Bennett N.G. Race and the inheritance of low birth weight. Soc. Biol. 47 (2000) 77-93
11. Demers A., Ayotte P., Brisson J., Dodin S., Robert J., and Dewailly E. Plasma concentrations of polychlorinated biphenyls and the risk of breast cancer: a congener-specific analysis. Am. J. Epidemiol. 155 (2002) 629-635
12. Dempsey D., Jacob III P., and Benowitz N.L. Accelerated metabolism of nicotine and cotinine in pregnant smokers. J. Pharmacol. Exp. Ther. 301 (2002) 594-598
13. Diczfalusy U., Miura J., Roh H.K., Mirghani R.A., Sayi J., Larsson H., Bodin K.G., Allqvist A., Jande M., Kim J.W., Aklillu E., Gustafsson L.L., and Bertilsson L. 4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians. Pharmacogenet. Genomics 18 (2008) 201-208
14. Dragnev K.H., Nims R.W., Fox S.D., Lindahl R., and Lubet R.A. Relative potencies of induction of hepatic drug-metabolizing enzyme genes by individual PCB congeners. Toxicol. Appl. Pharmacol. 132 (1995) 334-342
15. Dreisbach A.W., Japa S., Sigel A., Parenti M.B., Hess A.E., Srinouanprachanh S.L., Rettie A.E., Kim H., Farin F.M., Hamm L.L., and Lertora J.J. The Prevalence of CYP2C8, 2C9, 2J2, and soluble epoxide hydrolase polymorphisms in African Americans with hypertension. Am. J. Hypertens. 18 (2005) 1276-1281
16. Easterbrook J., Fackett D., and Li A.P. A comparison of aroclor 1254-induced and uninduced rat liver microsomes to human liver microsomes in phenytoin O-deethylation, coumarin 7-hydroxylation, tolbutamide 4-hydroxylation, S-mephenytoin 4′-hydroxylation, chloroxazone 6-hydroxylation and testosterone 6beta-hydroxylation. Chem. Biol. Interact. 134 (2001) 243-249
17. Environmental_Justice_and_Health_Union, Environmental Exposure and Racial Disparities, Environmental Justice & Health Union, Accessed 9/26/07 http://www.ejhu.org/about_us.html.
18. Fangstrom B., Athanasiadou M., Grandjean P., Weihe P., and Bergman A. Hydroxylated PCB metabolites and PCBs in serum from pregnant Faroese women. Environ. Health Perspect. 110 (2002) 895-899
19. Forgue S.T., and Allen J.R. Identification of an arene oxide metabolite of 2,2′,5-5′-tetrachlorobiphenyl by gas chromatography-mass spectroscopy. Chem. Biol. Interact. 40 (1982) 233-245
20. Fukami T., Nakajima M., Higashi E., Yamanaka H., McLeod H.L., and Yokoi T. A novel CYP2A6*20 allele found in African-American population produces a truncated protein lacking enzymatic activity. Biochem. Pharmacol. 70 (2005) 801-808
21. Fuller K.E. Low birth-weight infants: the continuing ethnic disparity and the interaction of biology and environment. Ethn. Dis. 10 (2000) 432-445
22. Gerstenberger S., Dellinger J., and Hansen L. Concentrations and frequencies of polychlorinated biphenyl congeners in a native American population that consumes Great Lakes fish. Clin. Toxicol. 38 7 (2000) 729-746
23. Gervot L., Rochat B., Gautier J.C., Bohnenstengel F., Kroemer H., de Berardinis V., Martin H., Beaune P., and de Waziers I. Human CYP2B6: expression, inducibility and catalytic activities. Pharmacogenetics 9 (1999) 295-306
24. Hansen L. The Ortho Side of PCBs: Occurrence and Disposition (1999), Kluwer Publishing, Norwell, MA 02061 Appendix Table 2. pp. 205-210
25. Haraguchi H., Kuroki H., Masuda Y., and Shigematsu N. Determination of methylthio and methylsulphone polychlorinated biphenyls in tissues of patients with 'yusho'. Food Chem. Toxicol. 22 (1984) 283-288
26. Haraguchi K., Kato Y., Kimura R., and Masuda Y. Tissue distribution of methylsulfonyl metabolites derived from 2,2′,4,5,5′-penta- and 2,2′,3,4′,5′,6-hexachlorobiphenyls in rats. Arch. Environ. Contam. Toxicol. 37 (1999) 135-142
27. Haraguchi K., Kato Y., Koga N., and Degawa M. Species differences in the tissue distribution of catechol and methylsulphonyl metabolites of 2,4,5,2′,5′-penta- and 2,3,4,2′,3′,6′-hexachlorobiphenyls in rats, mice, hamsters and guinea pigs. Xenobiotica 35 (2005) 85-96
28. Herrlin K., Massele A.Y., Jande M., Alm C., Tybring G., Abdi Y.A., Wennerholm A., Johansson I., Dahl M.L., Bertilsson L., and Gustafsson L.L. Bantu Tanzanians have a decreased capacity to metabolize omeprazole and mephenytoin in relation to their CYP2C19 genotype. Clin. Pharmacol. Ther. 64 (1998) 391-401
29. Herrlin K., Massele A.Y., Rimoy G., Alm C., Rais M., Ericsson O., Bertilsson L., and Gustafsson L.L. Slow chloroguanide metabolism in Tanzanians compared with white subjects and Asian subjects confirms a decreased CYP2C19 activity in relation to genotype. Clin. Pharmacol. Ther. 68 (2000) 189-198
30. Hovander L., Malmberg T., Athanasiadou M., Athanassiadis I., Rahm S., Bergman A., and Wehler E.K. Identification of hydroxylated PCB metabolites and other phenolic halogenated pollutants in human blood plasma. Arch. Environ. Contam. Toxicol. 42 (2002) 105-117
31. H.-P.I. James, R.A., Willman, E., Keller, J.A., Charles, J., 2002. Determinants of serum polychlorinated biphenyls and organochlorine pesticides measured in women from the child health and development cohort, 1963-1967. Environ. Health Perspect. 110, 617-640.
32. Hsu I.C., van Miller J.P., Seymour J.L., and Allen J.R. Urinary metabolites of 2,5,2′,5′-tetrachlorobiphenyl in the nonhuman primate. Proc. Soc. Exp. Biol. Med. 150 (1975) 185-188
33. Hsu Y.K., Holsen T.M., and Hopke P.K. Locating and quantifying PCB sources in Chicago: receptor modeling and field sampling. Environ. Sci. Technol. 37 (2003) 681-690
34. IJC, 2002. 11th Biennial Report-Great Lakes Water Quality, IJC 11th Biennial Report-Great Lakes Water Quality.
35. Ishida C., Koga N., Hanioka N., Saeki H.K., and Yoshimura H. Metabolism in vitro of 3,4,3′,4′- and 2,5,2′,5′-tetrachlorobiphenyl by rat liver microsomes and highly purified cytochrome P-450. J. Pharmacobiodyn. 14 (1991) 276-284
36. Kidd R.S., Curry T.B., Gallagher S., Edeki T., Blaisdell J., and Goldstein J.A. Identification of a null allele of CYP2C9 in an African-American exhibiting toxicity to phenytoin. Pharmacogenetics 11 (2001) 803-808
37. Koga N., Beppu M., and Yoshimura H. Metabolism in vivo of 3,4,5,3′,4′-pentachlorobiphenyl and toxicological assessment of the metabolite in rats. J. Pharmacobiodyn. 13 (1990) 497-506
38. Koga N., Kikuichi-Nishimura N., Hara T., Harada N., Ishii Y., Yamada H., Oguri K., and Yoshimura H. Purification and characterization of a newly identified isoform of cytochrome P450 responsible for 3-hydroxylation of 2,5,2′,5′-tetrachlorobiphenyl in hamster liver. Arch. Biochem. Biophys. 317 (1995) 464-470
39. Koga N., Kikuichi N., Kanamaru T., Ariyoshi N., Oguri K., and Yoshimura H. Hamster liver cytochrome P450 (CYP2A8) as a 4-hydroxylase for 2,5,2′,5′-tetrachlorobiphenyl. Biochem. Biophys. Res. Commun. 225 (1996) 685-688
40. Kramer, H.J., 2001. Comparative toxicokinetics of tetrachlorobenzyltoluenes (TCBTs) and polychlorobiphenyls (PCBs), Universiteit Utrecht, Faculteit Diergeneeskunde L2-http://www.library.uu.nl/digiarchief/dip/diss/1954469/inhoud.htm.
41. Kuroki H., Haraguchi K., Saito H., Masuda Y., Wehler E.K., and Bergman A. Accumulation of hydroxylated PCB metabolites in blood. Fukuoka Igaku Zasshi 84 (1993) 248-256
42. Langer P., Kocan A., Tajtakova M., Petrik J., Chovancova J., Drobna B., Jursa S., Pavuk M., Trnovec T., Sebokova E., and Klimes I. Human thyroid in the population exposed to high environmental pollution by organochlorinated pollutants for several decades. Endocr. Regul. 39 (2005) 13-20
43. Longnecker M.P., Klebanoff M.A., Brock J.W., and Zhou H. Polychlorinated biphenyl serum levels in pregnant subjects with diabetes. Diabetes Care 24 (2001) 1099-1101
44. Longnecker M.P., Klebanoff M.A., Brock J.W., and Guo X. Maternal levels of polychlorinated biphenyls in relation to preterm and small-for-gestational-age birth. Epidemiology 16 (2005) 641-647
45. McGraw Sr. J.E., and Waller D.P. Specific human CYP 450 isoform metabolism of a pentachlorobiphenyl (PCB-IUPAC# 101). Biochem. Biophys. Res. Commun. 344 (2006) 129-133
46. Miksys S., Lerman C., Shields P.G., Mash D.C., and Tyndale R.F. Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain. Neuropharmacology 45 (2003) 122-132
47. Millikan D.E., Duell R., Tse Chiu-Kit E.J., Savitz D.A., Beach J., Edmiston S., Jackson S., and Newman B. Dichlorodiphenyldichloroethene, polychlorinated biphenyls, and breast cancer among African-American and White Women in North Carolina. Cancer, Epidemiol., Biomarkers Prevent. 9 (2000) 1233-1240
48. Mirghani R.A., Sayi J., Aklillu E., Allqvist A., Jande M., Wennerholm A., Eriksen J., Herben V.M., Jones B.C., Gustafsson L.L., and Bertilsson L. CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population. Pharmacogenet. Genomics 16 (2006) 637-645
49. Moolchan E.T., Franken F.H., and Jaszyna-Gasior M. Adolescent nicotine metabolism: ethnoracial differences among dependent smokers. Ethn. Dis. 16 (2006) 239-243
50. Nakajima M., Kuroiwa Y., and Yokoi T. Interindividual differences in nicotine metabolism and genetic polymorphisms of human CYP2A6. Drug Metab. Rev. 34 (2002) 865-877
51. N.I.T. Program, 2006. NTP toxicology and carcinogenesis studies of a binary mixture of 3,3′,4,4′,5-pentachlorobiphenyl (PCB 126) (CAS No. 57465-28-8) and 2,3′,4,4′,5-pentachlorobiphenyl (PCB 118) (CAS No. 31508-00-6) in female harlan Sprague-Dawley rats (Gavage Studies), Natl Toxicol Program Tech Rep Ser, 1-218.
52. Ohta C., Haraguchi K., Kato Y., and Koga N. Metabolism of 2,3′,4,4′,5-pentachlorobiphenyl in guinea pig microsomes. Fukuoka Igaku Zasshi 96 (2005) 232-240
53. Park J.S., Linderholm L., Charles M.J., Athanasiadou M., Petrik J., Kocan A., Drobna B., Trnovec T., Bergman A., and Hertz-Picciotto I. Polychlorinated biphenyls and their hydroxylated metabolites (OH-PCBS) in pregnant women from eastern Slovakia. Environ. Health Perspect. 115 (2007) 20-27
54. Perera F.P., Rauh V., Tsai W.Y., Kinney P., Camann D., Barr D., Bernert T., Garfinkel R., Tu Y.H., Diaz D., Dietrich J., and Whyatt R.M. Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population. Environ. Health Perspect. 111 (2003) 201-205
55. Raucy J.L., Mueller L., Duan K., Allen S.W., Strom S., and Lasker J.M. Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes. J. Pharmacol. Exp. Ther. 302 (2002) 475-482
56. Safe S. Toxicology, structure-function relationship, and human and environmental health impacts of polychlorinated biphenyls: progress and problems. Environ. Health Perspect. 100 (1993) 259-268
57. Sams C., Cocker J., and Lennard M.S. Biotransformation of chlorpyrifos and diazinon by human liver microsomes and recombinant human cytochrome P450s (CYP). Xenobiotica 34 (2004) 861-873
58. Sandau C.D., Ayotte P., Dewailly E., Duffe J., and Norstrom R.J. Pentachlorophenol and hydroxylated polychlorinated biphenyl metabolites in umbilical cord plasma of neonates from coastal populations in Quebec. Environ. Health Perspect. 110 (2002) 411-417
59. Schantz S. Developmental neurotoxicity of PCBs in humans: what do we know and where do we go from here?. Neurotoxicol. Terato. 18 3 (1996) 217-227
60. Schnellmann R.G., Putnam C.W., and Sipes I.G. Metabolism of 2,2′,3,3′,6,6′-hexachlorobiphenyl and 2,2′,4,4′,5,5′-hexachlorobiphenyl by human hepatic microsomes. Biochem. Pharmacol. 32 (1983) 3233-3239
61. Schoedel K.A., Sellers E.M., Palmour R., and Tyndale R.F. Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration. Mol. Pharmacol. 63 (2003) 96-104
62. Shimada T., and Sawabe Y. Activation of 3,4,3′,4′-tetrachlorobiphenyl to protein-bound metabolites by rat liver microsomal cytochrome P-448-containing monooxygenase system. Toxicol. Appl. Pharmacol. 70 (1983) 486-493
63. Stresser D.M., and Kupfer D. Catalytic characteristics of CYP3A4: requirement for a phenolic function in ortho hydroxylation of estradiol and mono-O-demethylated methoxychlor. Biochemistry 36 (1997) 2203-2210
64. Sun P., Basu I., Blanchard P., Brice K.A., and Hites R.A. Temporal and spatial trends of atmospheric polychlorinated biphenyl concentrations near the Great Lakes. Environ. Sci. Technol. 41 (2007) 1131-1136
65. Tabrizi A.R., Zehnbauer B.A., Borecki I.B., McGrath S.D., Buchman T.G., and Freeman B.D. The frequency and effects of cytochrome P450 (CYP) 2C9 polymorphisms in patients receiving warfarin. J. Am. Coll. Surg. 194 (2002) 267-273
66. USEPA, 2003. Second National Report on Human Exposure to Environmental Chemicals. U.S. Environmental Protection Agency, Baltimore, MD.
67. van der Ven K., van der Ven H., Thibold A., Bauer O., Kaisi M., Mbura J., Mgaya H.N., Weber N., Diedrich K., and Krebs D. Chlorinated hydrocarbon content of fetal and maternal body tissues and fluids in full term pregnant women: a comparison of Germany versus Tanzania. Hum. Reprod. 1 7 Suppl. (1992) 95-100
68. Waller D., Presperin C., Drum M., Negrusz A., Larsen A., van der Ven H., and Hibbard J. Great lakes sport fish as a source of maternal and fetal exposure to chlorinated hydrocarbons. Toxicol. Ind. Health (1996)
69. Weiserbs K.F., Jacobson J.S., Begg M.D., Wang L.W., Wang Q., Agrawal M., Norkus E.P., Young T.L., and Santella R.M. A cross-sectional study of polycyclic aromatic hydrocarbon-DNA adducts and polymorphism of glutathione S-transferases among heavy smokers by race/ethnicity. Biomarkers 8 (2003) 142-155
70. WHO, 2005. WHO/WHO Sites/Food Safety/Chemical Risk in Food, WHO/WHO Sites/Food Safety/Chemical Risk in Food.
71. Yamazaki H., Inoue K., Hashimoto M., and Shimada T. Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch. Toxicol. 73 (1999) 65-70