Aristolochic acid induces heart failure in zebrafish embryos that is mediated by inflammation

Toxicological Sciences

Volumn 100, Issue 2, 2007, Pages 486-494

  Huang, Cheng chen ^a   Chen, Peng Chi ^a,b   Huang, Chin Wei ^a   Yu, John ^a,b  

^a INSTITUTE OF CELLULAR AND ORGANISMIC BIOLOGY   (Taiwan)

^b NATIONAL TAIWAN OCEAN UNIVERSITY   (Taiwan)

Author keywords

Aristolochic acid; Cox 2; Heart failure; Inflammation; Zebrafish

Indexed keywords

ARISTOLOCHIC ACID; CYCLOOXYGENASE 2; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOXORUBICIN; INTERLEUKIN 1BETA; ISOPRENALINE; METOPROLOL; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CELL DAMAGE; CONTROLLED STUDY; EMBRYO; EMBRYOTOXICITY; HEART FAILURE; HEART HYPERTROPHY; HISTOPATHOLOGY; INFLAMMATION; LETHALITY; NONHUMAN; PATHOPHYSIOLOGY; TRANSMISSION ELECTRON MICROSCOPY; ZEBRA FISH;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ARISTOLOCHIC ACIDS; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG SYNERGISM; EMBRYO, NONMAMMALIAN; ENDOCARDIUM; GENE EXPRESSION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; HEART FAILURE; INFLAMMATION; ISOPROTERENOL; METOPROLOL; MUTAGENS; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; NITROBENZENES; SULFONAMIDES; ZEBRAFISH;

DANIO RERIO;

EID: 36249028714     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm235     Document Type: Article

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