The contribution of podocytes to chronic allograft nephropathy

Nephron - Experimental Nephrology

Volumn 111, Issue 1, 2009, Pages

  Pippin, Jeffrey ^a   Kumar, Vineeta ^a   Stein, Alicia ^b   Jablonski, Paula ^b   Shankland, Stuart J ^a   Davis, Connie L ^a,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b MONASH UNIVERSITY   (Australia)

^c NONE   (United States)

Author keywords

Chronic allograft nephropathy; Kidney transplant; Podocyte

Indexed keywords

NEPHRIN; PODOCIN; SYNAPTOPODIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL FUNCTION; CELL LOSS; CHRONIC ALLOGRAFT NEPHROPATHY; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DARK AGOUTI RAT; GLOMERULOSCLEROSIS; GRAFT FAILURE; HISTOLOGY; IMMUNOHISTOCHEMISTRY; ISOGRAFT; KIDNEY TRANSPLANTATION; MALE; NEPHRECTOMY; NONHUMAN; PATHOLOGY; PODOCYTE; PRIORITY JOURNAL; PROTEIN URINE LEVEL; PROTEINURIA; RAT; UNINEPHRECTOMY; URINARY EXCRETION;

ANIMALS; CELL COUNT; CHRONIC DISEASE; CREATININE; DISEASE MODELS, ANIMAL; GLOMERULONEPHRITIS; KIDNEY TRANSPLANTATION; MALE; MEMBRANE PROTEINS; MICROFILAMENT PROTEINS; PODOCYTES; PROTEINURIA; RATS; RATS, INBRED STRAINS; TRANSPLANTATION, HOMOLOGOUS;

EID: 57049149060     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000178762     Document Type: Article

References (47)

1. Meier-Kriesche HU, Schold JD, Kaplan B: Long-term renal allograft survival: have we made significant progress or is it time to rethink our analytic and therapeutic strategies? Am J Transplant 2004;4:1289-1295.
2. Solez K, Colvin RB, Racusen LC, Sis B, Halloran PF, Birk PE, et al: Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy Am J Transplant 2007;7:518-526.
3. Mauiyyedi S, Crespo M, Collins AB, Schneeberger EE, Pascual MA, Saidman SL, et al: Acute humoral rejection in kidney transplantation. II. Morphology, immunopathology, and pathologic classification. J Am Soc Nephrol 2002;13:779-787.
4. Mauiyyedi S, Pelle PD, Saidman S, Collins AB, Pascual M, Tolkoff-Rubin NE, et al: Chronic humoral rejection: identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries. J Am Soc Nephrol 2001;12:574-582.
5. Couser W: Recurrent glomerulonephritis in the renal allograft: an update of selected areas. Exp Clin Transplant 2005;3:283-288.
6. Shankland SJ: The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int 2006;69:2131-2147.
7. Mundel P, Shankland SJ: Podocyte biology and response to injury. J Am Soc Nephrol 2002;13:3005-3015.
8. Kriz W, Elger M, Hosser H, Hähnel B, Provoost A, Kränzlin B, Gretz N: How does podocyte damage result in tubular damage? Kidney Blood Press Res 1999;22:26-36.
9. Kriz W, Gretz N, Lemley KV: Progression of glomerular diseases: Is the podocyte the culprit? Kidney Int 1998;54:687-697.
10. Ruotsalainen V, Ljungberg P, Wartiovaara J, Lenkkeri U, Kestilä M, Jalanko H, et al: Nephrin is specifically located at the slit diaphragm of glomerular podocytes. Proc Natl Acad Sci USA 1999;96:7962-7967.
11. Schwarz K, Simons M, Reiser J, Saleem MA, Faul C, Kriz W, et al: Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. J Clin Invest 2001;108:1621-1629.
12. Saleem MA, Ni L, Witherden I, Tryggvason K, Ruotsalainen V, Mundel P, Mathieson PW: Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation. Am J Pathol 2002;161:1459-1466.
13. Nakatsue T, Koike H, Han GD, Suzuki K, Miyauchi N, Yuan H, et al: Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy. Kidney Int 2005;67:2239-2253.
14. Hosoyamada M, Yan K, Nishibori Y, Takiue Y, Kudo A, Kawakami H, et al: Nephrin and podocin expression around the onset of puromycin aminonucleoside nephrosis. J Pharmacol Sci 2005;97:234-241.
15. Roth SU, Sommer C, Mundel P, Kiessling M: Expression of synaptopodin, an actin-associated protein, in the rat hippocampus after limbic epilepsy. Brain Pathol 2001;11:169-181.
16. Mundel P, Heid HW, Mundel TM, Krüger M, Reiser J, Kriz W: Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J Cell Biol 1997;139:193-204.
17. Asanuma K, Kim K, Oh J, Giardino L, Chabanis S, Faul C, et al: Synaptopodin regulates the actin-bundling activity of α-actinin in an isoform-specific manner. J Clin Invest 2005;115:1188-1198.
18. Siu B, Saha J, Smoyer WE, Sullivan KA, Brosius FC: Reduction in podocyte density as a pathologic feature in early diabetic nephropathy in rodents: prevention by lipoic acid treatment. BMC Nephrol 2006;7:6.
19. Macconi D, Bonomelli M, Benigni A, Plati T, Sangalli F, Longaretti L, et al: Pathophysiologic implications of reduced podocyte number in a rat model of progressive glomerular injury. Am J Pathol 2006;168:42-54.
20. Wharram BL, Goyal M, Wiggins JE, Sanden SK, Hussain S, Filipiak WE, et al: Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol 2005;16:2941-2952.
21. Pagtalunan ME, Miller PL, Jumping-Eagle S, Nelson RG, Myers BD, Rennke HG, et al: Podocyte loss and progressive glomerular injury in type II diabetes. J Clin Invest 1997;99:342-348.
22. Kretzler M: Role of podocytes in focal sclerosis: defining the point of no return. J Am Soc Nephrol 2005;16:2830-2832.
23. Kim YH, Goyal M, Kurnit D, Wharram B, Wiggins J, Holzman L, et al: Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat. Kidney Int 2001;60:957-968.
24. Nankivell BJ, Borrows RJ, Fung CLS, O'Connell PJ, Allen RDM, Chapman JR: Evolution and pathophysiology of renal-transplant glomerulosclerosis. Transplantation 2004;78:461-468.
25. Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Allen RDM, Chapman JR: Natural history, risk factors, and impact of subclinical rejection in kidney transplantation. Transplantation 2004;78:242-249.
26. Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Allen RDM, Chapman JR: The natural history of chronic allograft nephropathy. N Engl J Med 2003;349:2326-2333.
27. Coulson MT, Jablonski P, Howden BO, Thomson NM, Stein AN: Beyond operational tolerance: effect of ischemic injury on development of chronic damage in renal grafts. Transplantation 2005;80:353-361.
28. Jablonski P, Baxter K, Howden BO, Thomas AC, Marshall VC, Stein-Oakley A, Thomson NM: A reproducible model of chronic rejection in rat renal allografts. Aust NZ J Surg 1995;65:114-119.
29. Stein-Oakley AN, Jablonski P, Tzanidis A, Baxter K, Howden BO, Marshall VC, Thomson NM: Development of chronic injury and nature of interstitial infiltrate in a model of chronic renal allograft rejection. Transplantation 1993;56:1299-1305.
30. Tandon V, Botha JF, Banks J, Pontin AR, Pascoe MD, Kahn D: A tale of two kidneys - how long can a kidney transplant wait? Clin Transplant 2000;14:189-192.
31. Ojo AO, Wolfe RA, Held PJ, Port FK, Schmouder RL: Delayed graft function: risk factors and implications for renal allograft survival. Transplantation 1997;63:968-974.
32. Stratta RJ, Moore PS, Farney AC, Rogers J, Hartmann EL, Reeves-Daniel A, et al: Influence of pulsatile perfusion preservation on outcomes in kidney transplantation from expanded criteria donors. J Am Coll Surg 2007;204:873-884.
33. Vaughan MR, Pippin JW, Griffin SV, Krofft R, Fleet M, Haseley L, Shankland SJ: ATRA induces podocyte differentiation and alters nephrin and podocin expression in vitro and in vivo. Kidney Int 2005;68:133-144.
34. Eto N, Wada T, Inagi R, Takano H, Shimizu A, Kato H, et al: Podocyte protection by darbepoetin: preservation of the cytoskeleton and nephrin expression. Kidney Int 2007;72:455-463.
35. Nagase M, Shibata S, Yoshida S, Nagase T, Gotoda T, Fujita T: Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker. Hypertension 2006;47:1084-1093.
36. Logar CM, Brinkkoetter PT, Krofft RD, Pippin JW, Shankland SJ: Darbepoetin alfa protects podocytes from apoptosis in vitro and in vivo. Kidney Int 2007;72:489-498.
37. Marshall CB, Pippin JW, Krofft RD, Shankland SJ: Puromycin aminonucleoside induces oxidant-dependent DNA damage in podocytes in vitro and in vivo. Kidney Int 2006;70:1962-1973.
38. Monkawa T, Pippin J, Yo Y, Kopp JB, Alpers CE, Shankland SJ: The cyclin-dependent kinase inhibitor p21 limits murine mesangial proliferative glomerulonephritis. Nephron Exp Nephrol 2005;102:e8-e18.
39. Mundel P, Kriz W: Structure and function of podocytes: an update. Anat Embryol (Berl) 1995;192:385-397.
40. Pavenstädt H, Kriz W, Kretzler M: Cell biology of the glomerular podocyte. Physiol Rev 2002;83:253-307.
41. Barisoni L, Kopp JB: Update in podocyte biology: putting one's best foot forward. Curr Opin Nephrol Hypertens 2003;12:251-258.
42. Pätäri-Sampo A, Ihalmo P, Holthöfer H: Molecular basis of the glomerular filtration: nephrin and the emerging protein complex at the podocyte slit diaphragm. Ann Med 2006;38:483-492.
43. Kelly DJ, Aaltonen P, Cox AJ, Rumble JR, Langham R, Panagiotopoulos S, et al: Expression of the slit-diaphragm protein, nephrin, in experimental diabetic nephropathy: differing effects of anti-proteinuric therapies. Nephrol Dial Transplant 2002;17:1327-1332.
44. Luimula P, Ahola H, Wang SX, Solin ML, Aaltonen P, Tikkanen I, et al: Nephrin in experimental glomerular disease. Kidney Int 2000;58:1461-1468.
45. Garovic VD, Wagner SJ, Petrovic LM, Gray CE, Hall P, Sugimoto H, et al: Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia. Nephrol Dial Transplant 2007;22:1136-1143.
46. Menne J, Meier M, Park JK, Boehne M, Kirsch T, Lindschau C, et al: Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C α signaling in-vivo. Kidney Int 2006;70:1456-1462.
47. Wiggins RC: The spectrum of podocytopathies: a unifying view of glomerular diseases. Kidney Int 2007;71:1205-1214.