Monitoring Enzyme Reaction and Screening of Inhibitors of Acetylcholinesterase by Quantitative Matrix-Assisted Laser Desorption/Ionization Fourier Transform Mass Spectrometry

Journal of the American Society for Mass Spectrometry

Volumn 19, Issue 12, 2008, Pages 1849-1855

  Xu, Zhe ^a   Yao, Shengjun ^a   Wei, Yuanlong ^a   Zhou, Jing ^a   Zhang, Li ^a   Wang, Cuihong ^a   Guo, Yinlong ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL COMPOUNDS; DESORPTION; ENZYMES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; RATE CONSTANTS; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS;

ACETYLCHOLINESTERASE; CHEMICAL LIBRARIES; ENZYME INHIBITORS; ENZYME REACTIONS; FOURIER TRANSFORM MASS SPECTROMETRIES; GALANTAMINE; HIGH RESOLUTIONS; HUPERZINE A; INHIBITORY CONCENTRATIONS; INTERNAL STANDARDS; KINETIC CONSTANTS; KINETIC MEASUREMENTS; LASER DESORPTION/IONIZATION; MICHAELIS CONSTANTS; PRESENT METHODS; QUANTITATIVE ANALYSES; QUANTITATIVE MATRIXES; QUANTITATIVE TOOLS; RHIZOMA COPTIDIS;

FOURIER TRANSFORMS;

ACETYLCHOLINESTERASE; COPTIS CHINENSIS EXTRACT; GALANTAMINE; HUPERZINE A; RIVASTIGMINE;

ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; FOURIER TRANSFORM MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MICHAELIS CONSTANT;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; FOURIER ANALYSIS; KINETICS; LASERS; PLANT EXTRACTS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 56949102231     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2008.07.025     Document Type: Article

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