Polymorphic variants of genes encoding MTHFR, MTR, and MTHFD1 and the risk of depression in postmenopausal women in Poland

Maturitas

Volumn 61, Issue 3, 2008, Pages 252-255

  Slopien R ^a   Jasniewicz, K ^a   Meczekalski, B ^a   Warenik Szymankiewicz, A ^a   Lianeri, M ^a   Jagodzinski P P ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Depression; MTHFD1; MTHFR; MTR; Polymorphisms

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE CYCLOHYDROLASE; FORMATE TETRAHYDROFOLATE LIGASE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; METHYLENETETRAHYDROFOLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; DEPRESSION; DNA POLYMORPHISM; FEMALE; GENETIC CODE; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MENOPAUSAL SYNDROME; POLAND; POSTMENOPAUSE; RISK FACTOR;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ADULT; AGED; DEPRESSION; DNA; FEMALE; FORMATE-TETRAHYDROFOLATE LIGASE; GENOTYPE; HUMANS; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLAND; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTMENOPAUSE;

EID: 56949085834     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2008.08.002     Document Type: Article

References (32)

1. Gracia C.R., Freeman E.W., Sammel M.D., Lin H., and Mogul M. Hormones and sexuality during transition to menopause. Obstet Gynecol 109 (2007) 831-840
2. Herrmann W., and Obeid R. Biomarkers of folate and vitamin B(12) status in cerebrospinal fluid. Clin Chem Lab Med 45 (2007) 1614-1620
3. Redell J.B., and Dash P.K. Traumatic brain injury stimulates hippocampal catechol-O-methyl transferase expression in microglia. Neurosci Lett 413 (2007) 36-41
4. Mandelli L., Serretti A., Marino E., Pirovano A., Calati R., and Colombo C. Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders. Int J Neuropsychopharmacol 10 (2007) 437-447
5. Cantoni G.L. S-adenosylmethionine; a new intermediate fordem enzymatically from L-methionine and adenosinetriphosphate. J Biol Chem 204 (1953) 403-416
6. Arakawa T., Narisawa K., Tanno K., Hirooka Y., and Ono T. Megaloblastic anemia and mental retardation associated with hyperfolic-acidemia: probably due to N-5-methyltetrahydrofolate transferase deficiency. Tohoku J Exp Med 93 (1967) 1-22
7. Frosst P., Blom H.J., Milos R., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genet 10 (1995) 111-113
8. Hum D.W., Bell A.W., Rozen R., and MacKenzie R.E. Primary structure of a human trifunctional enzyme: isolation of a cDNA encoding methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthetase. J Biol Chem 263 (1988) 15946-15950
9. Robertson K.D., Uzvolgyi E., Liang G., et al. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res 27 (1999) 2291-2298
10. James S.J., Melnyk S., Pogribna M., Pogribny I.P., and Caudill M.A. Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr 132 (2002) 2361S-2366S
11. Paz M.F., Avila S., Fraga M.F., et al. Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. Cancer Res 62 (2002) 4519-4524
12. Brody L.C., Conley M., Cox C., et al. A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group. Am J Hum Genet 71 (2002) 1207-1215
13. Parle-McDermott A., Mills J.L., Kirke P.N., et al. MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruption placentae. Am J Med Genet A 132 (2005) 365-368
14. Hol F.A., van der Put N.M., Geurds M.P., et al. Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate-dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthetase) in patients with neural tube defects. Clin Genet 53 (1998) 119-125
15. Mostowska A., Hozyasz K.K., and Jagodzinski P.P. Maternal MTR genotype contributes to the risk of non-syndromic cleft lip and palate in the Polish population. Clin Genet 69 (2006) 512-517
16. Elhwuegi A.S. Central monoamines and their role in major depression. Prog Neuropsychopharmacol Biol Psychiatry 28 (2004) 435-451
17. Bakker R.C., and Brandjes D.P. Hyperhomocysteinaemia and associated disease. Pharm World Sci 19 (1997) 126-132
18. Frankenburg F.R. The role of one-carbon metabolism in schizophrenia and depression. Harv Rev Psychiatry 15 (2007) 146-160
19. Bjelland I., Tell G.S., Vollset S.E., Refsum H., and Ueland P.M. Folate, vitamin B12, homocysteine, and the MTHFR 677C → T polymorphism in anxiety and depression: the Hordaland Homocysteine Study. Arch Gen Psychiatry 60 (2003) 618-626
20. Kelly C.B., McDonnell A.P., Johnston T.G., et al. The MTHFR C677T polymorphism is associated with depressive episodes in patients from Northern Ireland. J Psychopharmacol 18 (2004) 567-571
21. Almeida O.P., Flicker L., Lautenschlager N.T., Leedman P., Vasikaran S., and van Bockxmeer F.M. Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life. Neurobiol Aging 26 (2005) 251-257
22. Coppen A., and Bolander-Gouaille C. Treatment of depression: time to consider folic acid and vitamin B12. J Psychopharmacol 19 (2005) 59-65
23. Regland B. Schizophrenia and single-carbon metabolism. Prog Neuropsychopharmacol Biol Psychiatry 29 (2005) 1124-1132
24. Andreoli V.M., and Maffei F. Blood-levels of S-adenosylmethionine in schizophrenia. Lancet 2 (1975) 922
25. Olney J.W. Role of excitotoxins in developmental neuropathology. APMIS Suppl 40 (1993) 103-112
26. Doolin M.T., Barbaux S., McDonnell M., Hoess K., Whitehead A.S., and Mitchell L.E. Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida. Am J Hum Genet 71 (2002) 1222-1226
27. Bosco P., Gueant-Rodriguez R.M., Anello G., et al. Methionine synthase (MTR) 2756 (A → G) polymorphism, double heterozygosity methionine synthase 2756 AG/methionine synthase reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having a child with Down syndrome. Am J Med Genet A 121 (2003) 219-224
28. Burzynski M., Duriagin S., Mostowska M., Wudarski M., and Chwalinska-Sadowska H. Jagodzinski PP. MTR 2756 A > G polymorphism is associated with the risk of systemic lupus erythematosus in the Polish population. Lupus 16 (2007) 450-454
29. Tsai M.Y., Bignell M., Yang F., Welge B.G., Graham K.J., and Hanson N.Q. Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine beta-synthase and A(2756)G of methionine synthase, with lowered plasma homocysteine levels. Atherosclerosis 1 (2000) 131-137
30. Chen J., Stampfer M.J., Ma J., et al. Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction. Atherosclerosis 3 (2001) 667-672
31. Silaste M.L., Rantala M., Sampi M., Alfthan G., Aro A., and Kesaniemi Y.A. Polymorphisms of key enzymes in homocysteine metabolism affect diet responsiveness of plasma homocysteine in healthy women. J Nutr 10 (2001) 2643-2647
32. Ulvik A., Vollset S.E., Hansen S., Gislefoss R., Jellum E., and Ueland P.M. Colorectal cancer and the methylenetetrahydrofolate reductase 677C → T and methionine synthase 2756A → G polymorphisms: a study of 2,168 case-control pairs from the JANUS cohort. Cancer Epidemiol Biomarkers Prev 13 (2004) 2175-2180