Biomarkers of folate and vitamin B12 status in cerebrospinal fluid

Clinical Chemistry and Laboratory Medicine

Volumn 45, Issue 12, 2007, Pages 1614-1620

  Herrmann, Wolfgang ^a   Obeid, Rima ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Cobalamin; Folate; Homocysteine; Methyl

Indexed keywords

BIOLOGICAL MARKER; COBALAMIN; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHIONINE; S ADENOSYLHOMOCYSTEINE;

BLOOD BRAIN BARRIER; BRAIN DISEASE; BRAIN LEVEL; BRAIN METABOLISM; CARBON METABOLISM; CEREBROSPINAL FLUID; CEREBROVASCULAR DISEASE; CONFERENCE PAPER; DEGENERATIVE DISEASE; DEMENTIA; DEPRESSION; FOLIC ACID BLOOD LEVEL; HUMAN; MENTAL DISEASE; METABOLITE; METHYLATION; NERVE CELL; NERVE DEGENERATION; NEUROLOGIC DISEASE; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; VITAMIN BLOOD LEVEL;

BIOLOGICAL MARKERS; BRAIN; FOLIC ACID; HOMOCYSTEINE; HUMANS; VITAMIN B 12;

EID: 36849063224     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2007.310     Document Type: Conference Paper

References (11)

1. Serot JM, Christmann D, Dubost T, Bene MC, Faure GC. CSF-folate levels are decreased in late-onset AD patients. J Neural Transm 2001;108:93-9.
2. Weir DG, Scott JM. Brain function in the elderly: role of vitamin B12 and folate. Br Med Bull 1999;55:669-82.
3. Scott JM, Molloy AM, Kennedy DG, Kennedy S, Weir DG. Effects of the disruption of transmethylation in the central nervous system: an animal model. Acta Neurol Scand Suppl 1994;154:27-31.
4. Tudball N, Griffiths R. Biochemical changes in the brain of experimental animals in response to elevated plasma homocystine and methionine. J Neurochem 1976;26:1149-54.
5. Garcia A, Zanibbi K. Homocysteine and cognitive function in elderly people. Can Med Assoc J 2004;171:897-904.
6. McCaddon A, Regland B, Hudson P, Davies G. Functional vitamin B(12) deficiency and Alzheimer's disease. Neurology 2002;58:1395-9.
7. Herrmann W, Knapp JP. Hyperhomocysteinemia: a new risk factor for degenerative diseases. Clin Lab 2002;48:471-81.
8. Selhub J, Bagley LC, Miller J, Rosenberg IH. B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr 2000;71:S614-20.
9. Herrmann W, Obeid R, Schorr H, Geisel J. The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings. Curr Drug Metab 2005;6:47-53.
10. Obeid R, Schorr H, Eckert R, Herrmann W. Vitamin B12 status in the elderly as judged by available biochemical markers. Clin Chem 2004;50:238-41.
11. Herrmann W, Schorr H, Obeid R, Geisel J. Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians. Am J Clin Nutr 2003;78:131-6.