The effects of sivelestat sodium hydrate (ONO-5046 · Na) on neutrophil phylaxis function in vitro

Japanese Pharmacology and Therapeutics

Volumn 31, Issue 1, 2003, Pages 85-91

  Akimoto, Akira ^a   Moro, Hideaki ^a   Namba, Toshiaki ^a   Matsuoka, Syozo ^a   Ohshima, Yukio ^a   Suzuki, Tatsuya ^a   Naito, Yukiko ^a  

^a NONE

Author keywords

Bactericidal activities; Human neutrophils; Phagocytic activity; Rat neutrophils; Sivelestat sodium hydrate; Superoxide production

Indexed keywords

SIVELESTAT;

ANIMAL CELL; ARTICLE; BACTERICIDAL ACTIVITY; CELL ACTIVITY; CELL FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ESCHERICHIA COLI; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OPSONIZATION; PHAGOCYTOSIS; RAT; STAPHYLOCOCCUS AUREUS;

EID: 0037286995     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Janoff A. Elastase in tissue injury. Annu Rev Med 1985; 36: 207-16.
2. Japanese source
3. Belaaouaj A, McCarthy R, Baumann M, Gao Z, Ley TJ, Abraham SN, et al. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat Med 1998; 4(5): 615-8.
4. Lee WL, Downey GP. Leukocyte elastase: physiological functions and role in acute lung injury. Am J Respir Crit Care Med 2001; 164: 896-904.
5. Zeiher BG, Matsuoka S, Kawabata K, Repine JE. Neutrophil elastase and acute lung injury:prospects for sivelestat and other neutrophil elastase inhibitors as therapeutics. Crit Care Med 2002; 30(5): S281-7.