Increased interleukin-12 release from peripheral blood mononuclear cells in nephrotic phase of minimal change nephrotic syndrome

Acta Paediatrica Taiwanica

Volumn 45, Issue 2, 2004, Pages 77-80

  Lin, Ching Yuang ^a,b   Chien, Jien Wen ^a,c  

^a CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^b CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Interleukin 12; Minimal change nephrotic syndrome; Th1 cells

Indexed keywords

INTERLEUKIN 12; LIPOPOLYSACCHARIDE;

ARTICLE; BLOOD LEVEL; CELLULAR IMMUNITY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DIAGNOSTIC KIT; DISEASE ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; MALE; MINIMAL CHANGE NEPHROTIC SYNDROME; NEPHROTIC PHASE; NEPHROTIC SYNDROME; PERIPHERAL BLOOD MONONUCLEAR CELL; REMISSION; TH1 CELL; URINE LEVEL;

CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERLEUKIN-12; LEUKOCYTES, MONONUCLEAR; MALE; NEPHROSIS, LIPOID;

EID: 3142701278     PISSN: 16088115     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Giangiacomo J, Cleary TG, Cole BR, Hoffstein P, Robson AM. Serum immunoglobulina, nephrotic syndrome. N Engl J Med 1975; 293:8-12.
2. Sobel AT, Intrator L. Lagure G. Serum immunoglobulins in idiopathic minimal change nephrotic syndrome. N Engl J Med 1976; 294:50.
3. Shalhoub RJ. Pathogenesis of lipoid nephrosis: a disorder of T-cell function. Lancet II 1974; 556-60.
4. Lin CY, Hsu HC. Histopathological and immunological studies in spontaneous remission of nephrotic syndrome after intercurrent measles infection. Nephron 1986; 42:110-5.
5. Sobel At, Branellec AI, Blanc CN, Lagrue GA. Physiochemical characterization of a vascular permeability factor produced by Con A stimulated human lymphocytes. J Immunol 1977; 119:1230-6.
6. Lin CY. T cell subsets and response to mitogens in patients with steroid responsive nephrotic syndrome. Clin J Microbiol Immunol 1985; 18:13-20.
7. Cherwinski HM, Schumacher JH, Brown KD, Mosmann TR. Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J Exp Med 1987; 166:1229-44.
8. Mosmann TR, Coffman RL. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989; 7:145-73.
9. Fowell D, McKnight AJ, Powrie F, Dyke R, Mason D. Subsets of CD4+ T cells and their role in the induction and prevention of autoimmunity. Immunol Rev 1991; 123:37-64.
10. Romagnani S. Human TH1 and TH2 subsets: doubt no more. Immunol Today 1991; 12:256-7.
11. Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol 1994; 12:227-57.
12. Heinzel FP, Schoenhaut DS, Rerko RM, Rosser LE, Gately MK. Recombinant interleukin 12 cures mice infected with Leishmania major. J Exp Med 1993; 177:1505-9.
13. Matsumoto K, Kanmatsuse K. Interleukin-15 and interleukin-12 have an additive effect on the release of vascular permeability factor by peripheral blood mononuclear cells in normal and in patients with nephrotic syndrome. Clin Nephrol, 1999; 52:10-8.
14. Stefanovic V, Golubovic E, Mitic-Zlatkovic M, Vlahovic P, Jovanovic O, Bogdanovic R. Interleukin-12 and interferon-gamma production in childhood idiopathic nephrotic syndrome, Ped Nephrol 1998; 12:463-6.
15. Lin JT, Lin CY, Huang FY, Lee PP, Chen CH, Hsu HC. A clinicopathological study of idiopathic nephrotic syndrome in children. Jpn J Nephrol 1995; 37:442-50.
16. Churg J, Sobin H. WHO monographs: renal disease. Classification and atlas of glomerular disease. Tokyo: Igaku-Soin. 1982.
17. Matsumoto K, Kanmatsuse K. Increased IL-12 release by monocytes in nephrotic patients. Clin Exp Immuno 1999; 117:361-7.
18. Matsumoto K, Ohi H, Kanmatsuse K. Interleukin 12 Upregulates the Release of Vascular Permeability Factor by Peripheral Blood Mononuclear Cells from Patients with Lipoid Nephrosis. Nephron 1998; 78:403-9.
19. Matsumoto K, Kanmatsues K, Interleukin-18 and interleukin-12 Synergize to Stimulate the Production of Vascular Permeability Factor by T Lymphocytes in Normal Subjects and in Patients with Minimal-Change Nephrotic Syndrome. Nephron 2000; 85:127-33.
20. Tokano Y, Morimoto S, Kanedo H, et al. Levels of IL-12 in the sera of patients with systemic lupus erythematosus (SLE): relation to Th1 and Th2-derived cytokines. Clin Exp Immumol 1999; 116:169-73.
21. Kuchroo VK, Das MP, Brown JA, et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 development pathways: Application to autoimmune disease therapy. Cell 1995; 80:707-18.
22. Stuber E, Strober W, Neurath M. Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion. J Exp Med 1996; 183:693-8.
23. Trinchieri G. Interleukin-12: a cytokine produced by antigen presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 1994; 84:4008-27.
24. Tamura T, Nakano H, Nagase H, et al. Early activation signal transduction pathways of Th1 and Th2 cell clones stimulated with anti-CD3. J Immunol 1995; 155:4692-701.
25. Rook GAW, Hernandez-Pando R, Lightman SL. Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance. Immunol Today 1994; 15:301-3.
26. Shankar AH, Titus RG. T cell and non-T cell compartments can independently determine resistance to Leishmania major. J Exp Med 1995; 181:845-55.
27. Pfeiffer C, Murray J, Madri J, Bottomly K. Selective activation of Th1 and Th2-like cells, in vivo response to human collagen IV. Immunol Rev 1991; 123:68-84.
28. Liblau RS, Singer SM, McDevitt HO. Th1 and Th2 CD4+ T-cells in the pathogenesis of organ-specific autoimmune disease. Immunol Today 1995; 16:34-8.