-
1
-
-
0342452981
-
A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration
-
Donehower LA, Varmus HE. A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration. Proc Natl Acad Sci U S A 1984; 81:6461-6465.
-
(1984)
Proc Natl Acad Sci U S A
, vol.81
, pp. 6461-6465
-
-
Donehower, L.A.1
Varmus, H.E.2
-
3
-
-
0031434606
-
Molecular mechanisms in retrovirus DNA integration
-
Asante-Appiah E, Skalka AM. Molecular mechanisms in retrovirus DNA integration. Antiviral Res 1997; 36:139-156.
-
(1997)
Antiviral Res
, vol.36
, pp. 139-156
-
-
Asante-Appiah, E.1
Skalka, A.M.2
-
5
-
-
34047200871
-
Virus evolution reveals an exclusive role for LEDGF/p7S in chromosomal tethering of HIV
-
Hombrouck A, De Rijck J, Hendrix J, et al. Virus evolution reveals an exclusive role for LEDGF/p7S in chromosomal tethering of HIV. PLoS Pathog 2007; 3:47.
-
(2007)
PLoS Pathog
, vol.3
, pp. 47
-
-
Hombrouck, A.1
De Rijck, J.2
Hendrix, J.3
-
6
-
-
0027199982
-
Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection
-
Bukrinsky MI, Sharova N, McDonald TL, Pushkarskaya T, Tarpley WG, Stevenson M. Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection. Proc Natl Acad Sci U S A 1993; 90:6125-6129.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 6125-6129
-
-
Bukrinsky, M.I.1
Sharova, N.2
McDonald, T.L.3
Pushkarskaya, T.4
Tarpley, W.G.5
Stevenson, M.6
-
7
-
-
0032189652
-
Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction
-
Esposito D, Craigie R. Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction. EMBO J 1998; 17:5832-5843.
-
(1998)
EMBO J
, vol.17
, pp. 5832-5843
-
-
Esposito, D.1
Craigie, R.2
-
8
-
-
0036184671
-
Ty3 integrase is required for initiation of reverse transcription
-
Nymark-McMahon MH, Beliakova-Bethell NS, Darlix JL, Le Grice SE Sandmeyer SB. Ty3 integrase is required for initiation of reverse transcription. J Virol 2002; 76:2804-2816.
-
(2002)
J Virol
, vol.76
, pp. 2804-2816
-
-
Nymark-McMahon, M.H.1
Beliakova-Bethell, N.S.2
Darlix, J.L.3
Le Grice, S.E.4
Sandmeyer, S.B.5
-
9
-
-
0141870046
-
Replication of chimeric human immunodeficiency virus type I (HIV-1) containing HIV-2 integrase (IN): Naturally selected mutations in IN augment DNA synthesis
-
Padow M, Lai L, Deivanayagam C, et al. Replication of chimeric human immunodeficiency virus type I (HIV-1) containing HIV-2 integrase (IN): naturally selected mutations in IN augment DNA synthesis. J Virol 2003; 77:11050-11059.
-
(2003)
J Virol
, vol.77
, pp. 11050-11059
-
-
Padow, M.1
Lai, L.2
Deivanayagam, C.3
-
10
-
-
2342648913
-
Interaction between human immunodeficiency virus type 1 reverse transcriptase and integrase proteins
-
Hehl EA, Joshi P, Kalpana GV, Prasad VR. Interaction between human immunodeficiency virus type 1 reverse transcriptase and integrase proteins. J Virol 2004; 78:5056-5067.
-
(2004)
J Virol
, vol.78
, pp. 5056-5067
-
-
Hehl, E.A.1
Joshi, P.2
Kalpana, G.V.3
Prasad, V.R.4
-
11
-
-
0031886388
-
Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir)
-
Este JA, Cabrera C, Schols D, et al. Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir). Mol Pharmacol 1998; 53:340-345.
-
(1998)
Mol Pharmacol
, vol.53
, pp. 340-345
-
-
Este, J.A.1
Cabrera, C.2
Schols, D.3
-
12
-
-
34147136222
-
Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
-
Grinsztejn B, Nguyen BY, Katlama C, et al. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial. Lancet 2007; 369:1261-1269.
-
(2007)
Lancet
, vol.369
, pp. 1261-1269
-
-
Grinsztejn, B.1
Nguyen, B.Y.2
Katlama, C.3
-
13
-
-
34248177765
-
Results of BENCHMRK-1, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus
-
25-29 February, Los Angeles, CA, USA
-
Cooper D, Gatell J, Rockstroh J. Results of BENCHMRK-1, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus. 14th Conference on Retroviruses and Opportunistic Infections. 25-29 February 2007, Los Angeles, CA, USA.
-
(2007)
14th Conference on Retroviruses and Opportunistic Infections
-
-
Cooper, D.1
Gatell, J.2
Rockstroh, J.3
-
14
-
-
34248205567
-
Results of BENCHMRK-2, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus
-
25-29 February, Los Angeles, CA, USA
-
Steigbigel R, Kumar P, Eton J. Results of BENCHMRK-2, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus. 14th Conference on Retroviruses and Opportunistic Infections. 25-29 February 2007, Los Angeles, CA, USA.
-
(2007)
14th Conference on Retroviruses and Opportunistic Infections
-
-
Steigbigel, R.1
Kumar, P.2
Eton, J.3
-
15
-
-
0026459411
-
Requirement of active human immunodeficiency virus type 1 trite rase enzyme for productive infection of human T-lymphM cells
-
LaFemina RL, Schneider CL, Robbins HL, et al. Requirement of active human immunodeficiency virus type 1 trite rase enzyme for productive infection of human T-lymphM cells. J Virol 1992; 66:7414-7419.
-
(1992)
J Virol
, vol.66
, pp. 7414-7419
-
-
LaFemina, R.L.1
Schneider, C.L.2
Robbins, H.L.3
-
16
-
-
0034723439
-
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
-
Hazuda DJ, Felock P, Witmer M, et al. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science 2000; 287:646-650.
-
(2000)
Science
, vol.287
, pp. 646-650
-
-
Hazuda, D.J.1
Felock, P.2
Witmer, M.3
-
17
-
-
7744240084
-
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360
-
Fikkert V, Hombrouck A, Van Remoortel B, et al. Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360. AIDS 2004; 18:2019-2028.
-
(2004)
AIDS
, vol.18
, pp. 2019-2028
-
-
Fikkert, V.1
Hombrouck, A.2
Van Remoortel, B.3
-
18
-
-
3242769788
-
Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques
-
Hazuda DJ, Young SD, Guare JP, et al. Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques. Science 2004; 305:528-532.
-
(2004)
Science
, vol.305
, pp. 528-532
-
-
Hazuda, D.J.1
Young, S.D.2
Guare, J.P.3
-
19
-
-
37249065868
-
Zhao Resistance to the HIV-integrase inhibitor raltegravir: Analysis of protocol 005, a Phase II study in patients with triple-class resistant HIV- 1 infection
-
Hazuda DJ, Miller MD, Nguyen BY, Zhao Resistance to the HIV-integrase inhibitor raltegravir: analysis of protocol 005, a Phase II study in patients with triple-class resistant HIV- 1 infection. Antivir Ther 2007; 12 Suppl 1:S10.
-
(2007)
Antivir Ther
, vol.12
, Issue.SUPPL. 1
-
-
Hazuda, D.J.1
Miller, M.D.2
Nguyen, B.Y.3
-
20
-
-
37849002059
-
Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)
-
Shimura K, Kodama E, Sakagami Y, et al. Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). J Virol 2008; 82:764-774.
-
(2008)
J Virol
, vol.82
, pp. 764-774
-
-
Shimura, K.1
Kodama, E.2
Sakagami, Y.3
-
21
-
-
40549125135
-
Resistance and cross-resistance to first generation integrase inhibitors: Insights from a Phase II study of elvitegarvir (GS-9137)
-
McColl DJ, Fransen S, Gupta S, et al. Resistance and cross-resistance to first generation integrase inhibitors: insights from a Phase II study of elvitegarvir (GS-9137). Antivir Ther 2007; 12 Suppl 1:S11.
-
(2007)
Antivir Ther
, vol.12
, Issue.SUPPL. 1
-
-
McColl, D.J.1
Fransen, S.2
Gupta, S.3
-
22
-
-
27544496497
-
An automated genotyping system for analysis of HIV-1 and other microbial sequences
-
de Oliveira T, Deforche K, Cassol S, et al. An automated genotyping system for analysis of HIV-1 and other microbial sequences. Bioinformatics 2005; 21:3797-3800.
-
(2005)
Bioinformatics
, vol.21
, pp. 3797-3800
-
-
de Oliveira, T.1
Deforche, K.2
Cassol, S.3
-
23
-
-
56749175874
-
-
Los Alamos National Laboratory HIV Database Tools. (Updated 22 July 2008. Accessed 18 September 2008.) Available from www.hiv.lanl.gov.
-
Los Alamos National Laboratory HIV Database Tools. (Updated 22 July 2008. Accessed 18 September 2008.) Available from www.hiv.lanl.gov.
-
-
-
-
24
-
-
0002222776
-
HIV signature and sequence variation analysis._In
-
Edited by & GH Learn. Dordrecht: Kluwer Academic Publishers
-
Korber B. HIV signature and sequence variation analysis._In Computational analysis of HIV molecular sequences. Edited by AG Rodrigo & GH Learn. Dordrecht: Kluwer Academic Publishers 2000; pp. 55-72.
-
(2000)
Computational analysis of HIV molecular sequences
, pp. 55-72
-
-
Korber, B.1
-
25
-
-
0028195026
-
Construction and in vitro properties of HIV-1 mutants with deletions in 'nonessential' genes
-
Gibbs JS, Regier DA, Desrosiers RC. Construction and in vitro properties of HIV-1 mutants with deletions in 'nonessential' genes. AIDS Res Hum Retroviruses 1994; 10:343-350.
-
(1994)
AIDS Res Hum Retroviruses
, vol.10
, pp. 343-350
-
-
Gibbs, J.S.1
Regier, D.A.2
Desrosiers, R.C.3
-
26
-
-
33745886803
-
Use of a novel assay based on intact recombinant viruses expressing green (EGFP) or red (DsRed2) fluorescent proteins to examine the contribution of pol and env genes to overall HIV-1 replicative fitness
-
Weber J, Weberova J, Carobene M, et al. Use of a novel assay based on intact recombinant viruses expressing green (EGFP) or red (DsRed2) fluorescent proteins to examine the contribution of pol and env genes to overall HIV-1 replicative fitness. J Virol Methods 2006; 136:102-117.
-
(2006)
J Virol Methods
, vol.136
, pp. 102-117
-
-
Weber, J.1
Weberova, J.2
Carobene, M.3
-
27
-
-
23244434512
-
Montefiori, Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies
-
Li M, Gao E Mascola JR, et al. Montefiori, Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies. J Virol 2005; 79:10108-10125.
-
(2005)
J Virol
, vol.79
, pp. 10108-10125
-
-
Li, M.1
Gao, E.2
Mascola, J.R.3
-
28
-
-
10744226580
-
Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations
-
Fikkert V, Van Maele B, Vercammen J, et al. Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations. J Virol 2003; 77:11459-11470.
-
(2003)
J Virol
, vol.77
, pp. 11459-11470
-
-
Fikkert, V.1
Van Maele, B.2
Vercammen, J.3
-
29
-
-
66249092459
-
Novel HIV-1 integrase mutations, found as minority quasispecies in patients naïve to integrase inhibitors, are associated with decreased susceptibility to integrase inhibitors
-
3-6 February, Boston, MA, USA
-
Ceccherini-Silberstein F, Van Baelen K, Armenia D, et al. Novel HIV-1 integrase mutations, found as minority quasispecies in patients naïve to integrase inhibitors, are associated with decreased susceptibility to integrase inhibitors in vitro. 1Sth Conference on Retroviruses and Opportunistic Infections. 3-6 February 2008, Boston, MA, USA.
-
(2008)
vitro. 1Sth Conference on Retroviruses and Opportunistic Infections
-
-
Ceccherini-Silberstein, F.1
Van Baelen, K.2
Armenia, D.3
-
30
-
-
0031684417
-
Analysis of a large collection of natural HIV-1 integrase sequences, including those from long-term nonprogressors
-
Skinner LM, Lamers SL, Sanders JC, Eyster ME, Goodenow MM, Katzman M. Analysis of a large collection of natural HIV-1 integrase sequences, including those from long-term nonprogressors. J Acquir Immune Defic Syndr Hum Retrovirol 1998; 19:99-110.
-
(1998)
J Acquir Immune Defic Syndr Hum Retrovirol
, vol.19
, pp. 99-110
-
-
Skinner, L.M.1
Lamers, S.L.2
Sanders, J.C.3
Eyster, M.E.4
Goodenow, M.M.5
Katzman, M.6
-
31
-
-
34447263572
-
Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance
-
Lataillade M, Chiarella J, Kozal MJ. Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance. Antivir Ther 2007; 12:563-570.
-
(2007)
Antivir Ther
, vol.12
, pp. 563-570
-
-
Lataillade, M.1
Chiarella, J.2
Kozal, M.J.3
-
32
-
-
0035805256
-
Natural selection results in conservation of HIV-1 integrase activity despite sequence variability
-
Reinke R, Steffen NR, Robinson WE. Natural selection results in conservation of HIV-1 integrase activity despite sequence variability. AIDS 2001; 15:823-830.
-
(2001)
AIDS
, vol.15
, pp. 823-830
-
-
Reinke, R.1
Steffen, N.R.2
Robinson, W.E.3
-
33
-
-
3843061223
-
Evolution of resistance to drugs in HIV-1-infected patients failing antiretroviral therapy
-
Kantor R, Shafer RW, Follansbee S, et al. Evolution of resistance to drugs in HIV-1-infected patients failing antiretroviral therapy. AIDS 2004; 18:1503-1511.
-
(2004)
AIDS
, vol.18
, pp. 1503-1511
-
-
Kantor, R.1
Shafer, R.W.2
Follansbee, S.3
-
34
-
-
30544446067
-
Genetic evolution of HIV in patients remaining on a stable HAART regimen despite insufficient viral suppression
-
Kristiansen TB, Pedersen AG, Eugen-Olsen J, Katzenstein TL, Lundgren JD. Genetic evolution of HIV in patients remaining on a stable HAART regimen despite insufficient viral suppression. Scand J Infect Dis 2005; 37:890-901.
-
(2005)
Scand J Infect Dis
, vol.37
, pp. 890-901
-
-
Kristiansen, T.B.1
Pedersen, A.G.2
Eugen-Olsen, J.3
Katzenstein, T.L.4
Lundgren, J.D.5
-
36
-
-
52749083002
-
Low level of baseline resistance to integrase inhibitors L731,988 and L870,810 in randomly selected subtype B and non-B HIV-1 strains
-
Van Baelen K, Clynhens M, Rondelez E, et al. Low level of baseline resistance to integrase inhibitors L731,988 and L870,810 in randomly selected subtype B and non-B HIV-1 strains. Antivir Ther 2007; 12 Suppl 1:S7.
-
(2007)
Antivir Ther
, vol.12
, Issue.SUPPL. 1
-
-
Van Baelen, K.1
Clynhens, M.2
Rondelez, E.3
-
37
-
-
42049119625
-
Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro
-
Malet I, Delelis O, Valantin A, et al. Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro. Antimicrob Agents Chemother 2008; 52:1351-1358.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 1351-1358
-
-
Malet, I.1
Delelis, O.2
Valantin, A.3
-
38
-
-
0026684826
-
Requirement for a conserved serine in both processing and joining activities of retroviral integrase
-
Katz RA, Mack JP, Merkel G, et al. Requirement for a conserved serine in both processing and joining activities of retroviral integrase. Proc Natl Acad Sci U S A 1992; 89:6741-6745.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 6741-6745
-
-
Katz, R.A.1
Mack, J.P.2
Merkel, G.3
-
39
-
-
48449089625
-
In vitro cross-resistance studies of five different classes of integrase inhibitors in recombinant HIV-1
-
Ren C, May S, Miletti T, Bedard J. In vitro cross-resistance studies of five different classes of integrase inhibitors in recombinant HIV-1. Antivir Ther 2007; 12 Suppl 1:S3.
-
(2007)
Antivir Ther
, vol.12
, Issue.SUPPL. 1
-
-
Ren, C.1
May, S.2
Miletti, T.3
Bedard, J.4
-
40
-
-
0028225959
-
Human immunodeficiency virus type 1 integrase: Effect on viral replication of mutations at highly conserved residues
-
Cannon PM, Wilson W, Byles E, Kingsinan SM, Kingsman A Human immunodeficiency virus type 1 integrase: effect on viral replication of mutations at highly conserved residues. J Virol 1994; 68:4768-4775.
-
(1994)
J Virol
, vol.68
, pp. 4768-4775
-
-
Cannon, P.M.1
Wilson, W.2
Byles, E.3
Kingsinan, S.M.4
Kingsman, A.5
-
41
-
-
0028924020
-
Human immunodeficiency virus type 1 integrase: Effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells
-
Wiskerchen M, Muesing MA. Human immunodeficiency virus type 1 integrase: effects of mutations on viral ability to integrate, direct viral gene expression from unintegrated viral DNA templates, and sustain viral propagation in primary cells. J Virol 1995; 69:376-386.
-
(1995)
J Virol
, vol.69
, pp. 376-386
-
-
Wiskerchen, M.1
Muesing, M.A.2
-
42
-
-
0030478950
-
Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity
-
Zheng R, Jenkins TM, Craigie R. Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity. Proc Natl Acad Sci U S A 1996; 93:13659-13664.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 13659-13664
-
-
Zheng, R.1
Jenkins, T.M.2
Craigie, R.3
-
43
-
-
0028915128
-
Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication
-
Engelman A, Englund G, Orenstein JM, Martin MA, Craigie R. Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication. J Virol 199S; 69:2729-2736.
-
J Virol
, vol.199 S
, Issue.69
, pp. 2729-2736
-
-
Engelman, A.1
Englund, G.2
Orenstein, J.M.3
Martin, M.A.4
Craigie, R.5
-
44
-
-
21644477889
-
Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progression
-
Troyer RM, Collins KR, Abraha A, et al. Changes in human immunodeficiency virus type 1 fitness and genetic diversity during disease progression. J Virol 2005; 79:9006-9018.
-
(2005)
J Virol
, vol.79
, pp. 9006-9018
-
-
Troyer, R.M.1
Collins, K.R.2
Abraha, A.3
-
45
-
-
48449088969
-
Specific mutations related to resistance to HIV-1 integrase inhibitors are associated with reverse transcriptase mutations in HAART-treated patients
-
Ceccherini-Silberstein E, Malet I, Fabeni L, et al. Specific mutations related to resistance to HIV-1 integrase inhibitors are associated with reverse transcriptase mutations in HAART-treated patients. Antivir Ther 2007; 12 Suppl 1:S6.
-
(2007)
Antivir Ther
, vol.12
, Issue.SUPPL. 1
-
-
Ceccherini-Silberstein, E.1
Malet, I.2
Fabeni, L.3
-
46
-
-
48449104295
-
Effects of protease and reverse transcriptase inhibitor-resistance mutations on integrase polymorphism in multidrug resistance cases
-
Suzuki H, Fujino M, Matsuda M, Yen H, Iwantani Y, Sigiura W, Effects of protease and reverse transcriptase inhibitor-resistance mutations on integrase polymorphism in multidrug resistance cases. Antivir Ther 2007; 12 Suppl 1:S4.
-
(2007)
Antivir Ther
, vol.12
, Issue.SUPPL. 1
-
-
Suzuki, H.1
Fujino, M.2
Matsuda, M.3
Yen, H.4
Iwantani, Y.5
Sigiura, W.6
|