Natural selection results in conservation of HIV-1 integrase activity despite sequence variability

AIDS

Volumn 15, Issue 7, 2001, Pages 823-830

  Reinke, Ryan ^a,b   Steffen, Nicholas R ^a,b   Robinson Jr , W Edward ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antiretroviral therapy; Biochemistry; Enzymology; Functional genomics; Natural selection; Virus evolution; Virus proteins

Indexed keywords

ANTIRETROVIRUS AGENT; CICHORIC ACID; INTEGRASE; INTEGRASE INHIBITOR; MUTANT PROTEIN; VIRUS RNA;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SENSITIVITY; DRUG TARGETING; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NATURAL SELECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; RNA SEQUENCE; VIROGENESIS; VIRUS DNA CELL DNA INTERACTION; VIRUS ISOLATION; VIRUS REPLICATION;

ANTI-HIV AGENTS; CAFFEIC ACIDS; GENE EXPRESSION; HELA CELLS; HIV INFECTIONS; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; KINETICS; PHYLOGENY; RNA PROCESSING, POST-TRANSCRIPTIONAL; SELECTION (GENETICS); SEQUENCE ANALYSIS, DNA; SUCCINATES; TUMOR CELLS, CULTURED; VARIATION (GENETICS); VIRUS INTEGRATION;

EID: 0035805256     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200105040-00002     Document Type: Article

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