Peroxynitrite decreases arrhythmias induced by ischaemia reperfusion in anaesthetized dogs, without involving mitochondrial K ATP channels

British Journal of Pharmacology

Volumn 155, Issue 7, 2008, Pages 1015-1024

  Kiss, A ^a   Juhasz L ^a   Huliak I ^a   Vegh A ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Arrhythmias; Free radicals; Mitochondrial K ATP channels; Nitric oxide; Peroxynitrite

Indexed keywords

3 NITROTYROSINE; 5 HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; PEROXYNITRITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE SEVERITY; DOG; DRUG ADMINISTRATION ROUTE; DRUG MECHANISM; HEART ARRHYTHMIA; HEART MITOCHONDRION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE FIBRILLATION; IN VIVO STUDY; INTRACORONARY DRUG ADMINISTRATION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; PRIORITY JOURNAL; SURVIVAL RATE; TISSUE LEVEL;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIAS, CARDIAC; CORONARY VESSELS; DECANOIC ACIDS; DOGS; FEMALE; HYDROXY ACIDS; MALE; MYOCARDIAL REPERFUSION INJURY; PEROXYNITROUS ACID; POTASSIUM CHANNELS; SEVERITY OF ILLNESS INDEX; SURVIVAL RATE; TYROSINE; VENTRICULAR FIBRILLATION;

EID: 56749177107     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.344     Document Type: Article

References (78)

1. Addicks K, Bloch W, Feelish M (1994). Nitric oxide modulates sympathetic neurotransmissiom at the prejunctional level. Microsc Res Tech 29: 161-168.
2. Alexander SPH, Matie A, Peters JA (2008). Guide to receptors and channels (GRAC) 3rd edition. Br J Pharmacol 153 (Suppl. 2): S1-S209.
3. Altug S, Demiryürek T, Ak D, Tungel M, Kanzik I (2001). Contribution of peroxynitrite to the beneficial effects of preconditioning on ischaemia-induced arrhythmias in rat isolated hearts. Eur J Pharmacol 415: 239-246.
4. Altug S, Demiryürek T, Kane KA, Kanzik J (2000). Evidence for the involvement of peroxynitrite in ischaemic preconditioning in rat isolated hearts. Br J Pharmacol 130: 125-131.
5. Baines CP, Goto M, Downey JM (1997). Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium. J Mol Cell Cardiol 29: 207-216.
6. Beckman JS, Chen J, Ischiropoulos H, Crow JP (1994). Oxidative chemistry of peroxynitrite. Methods Enzymol 233: 229-240.
7. Beckman JS, Crow JP (1992). Pathological implications of nitric oxide, superoxide and peroxynitrite formation. Biochem Soc Trans 21: 330-334.
8. Brack KE, Patel VH, Coote JH, Ng GA (2007). Nitric oxide mediates the vagal protective effect on ventricular fibrillation via effects on action potential duration restitution in the rabbit heart. J Physiol 583: 695-704.
9. Csonka C, Csont T, Ónódy A, Ferdinándy P (2001). Preconditioning decreases ischemia/reperfusion-induced peroxynitrite formation. Biochem Biophys Res Commun 285: 1217-1219.
10. Csonka C, Szilvássy Z, Fülöp F, Páli T, Blasig IE, Tósaki Á, Schulz R, Ferdinándy P (1999). Classic preconditioning decreases the harmful accumulation of nitric oxide during ischemia and reperfusion in rat hearts. Circulation 100: 2260-2266.
11. Danson EJ, Paterson DJ (2006). Reactive oxygen species and autonomic regulation of cardiac excitability. J Cardiovasc Electrophysiol 17: S104-S112.
12. Das DK, Engelman RM, Maulik N (1999). Oxygen free radical signaling in ischemic preconditioning. Ann NY Acad Sci 874: 49-65.
13. Downey JM, Cohen MV (1997). Signal transduction in ischemic preconditioning. Adv Exp Med Biol 430: 39-55.
14. Downey JM, Davis AM, Cohen MV (2007). Signaling pathways in ischemic preconditioning. Heart Fail Rev 12: 181-188.
15. Fatehi-Hassanabad Z, Parratt JR (1997). Genistein, an inhibitor of tyrosine kinase, prevents the antiarrhythmic effects of preconditioning. Eur J Pharmacol 338: 67-70.
16. Ferdinándy P, Schulz R (2001). Peroxynitrite. Toxic or protective in the heart? Circ Res 88: e12-e13.
17. Ferdinándy P, Schulz R (2003). Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning. Br J Pharmacol 138: 532-543.
18. Ferdinándy P, Schulz R, Baxter GF (2007). Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol Rev 59: 418-458.
19. Gönczi M, Papp R, Seprényi Gy, Végh Á (2008). Role of nitric oxide in the modulation of gap junctional channels. J Mol Cell Cardiol 44: 752 (abstract 97).
20. ATP channels and myocardial preconditioning: an update. Am J Physiol Heart Circ Physiol 285: H921-H930.
21. ++ dependence for mitochondrial superoxide formation and permeability transition evoked by peroxynitrite. J Cell Sci 120: 1908-1914.
22. György K, Végh Á, Rastegar MA, Papp JGy, Parratt JR (2000). Isosorbide-2-mononitrate reduces the consequences of myocardial ischaemia, including arrhythmia severity: implications for preconditioning. J Cardiovasc Drugs Ther 14: 481-488.
23. Hajnal Á, Nagy L, Parratt JR, Papp JGy, Végh Á (2005). Failure of N-2-mercaptopropionylglycine, a scavanger of reactive oxygen species, to modify the antiarrhythmic effect of ischaemic preconditioning in anaesthetised dogs. J Cardiovasc Drugs Ther 18: 449-459.
24. Hallström S, Franz M, Gasser H, Vodrazka M, Semsroth S, Losert EM et al. (2008). S-nitroso human serum albumin reduces ischaemia/ reperfusion injury in the pig heart after unprotected warm ischaemia. Cardiovasc Res 77: 506-514.
25. Hanley PJ, Mickel M, Löffler M, Brandt U, Daut J (2002). KATP channel independent targets of diazoxide and 5-hydroxydecanoate in the heart. J Physiol 542: 735-741.
26. Ichinose F, Buys ES, Neilan TG, Furutani EM, Morgan JG, Jassal DS et al. (2007). Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock. Circ Res 100: 130-139.
27. Iwamoto T, Miura T, Adachi T, Noto T, Ogawa T, Tsuchida A et al. (1991). Myocardial infarct size limiting effect of ischemic preconditioning was not attenuated by oxygen free radical scavangers in the rabbit. Circulation 83: 1015-1022.
28. ATP channels are not involved in the antiarrhythmic effect of peroxynitrite. J Mol Cell Cardiol 42 (Suppl. 1): S18.
29. 2 radicals in intact hearts with ischemia and reperfusion. Am J Physiol Heart Circ Physiol 284: H566-H574.
30. Kinugawa S, Huang H, Wang Z, Kaminski PM, Wolin MS, Hintze TH (2005). A defect of neouronal nitric oxide synthase increases xanthine oxidase-derived superoxide anion and attenuates the control of myocardial oxygen consumption by nitric oxide derived from endothelial nitric oxide synthase. Circ Res 96: 355-362.
31. Kis A, Végh Á, Papp JGy, Parratt JR (1999a). Repeated cardiac pacing extends the time during which canine hearts are protected against ischaemia-induced arrhythmias. Role of nitric oxide. J Mol Cell Cardiol 31: 1229-1241.
32. Kis A, Végh Á, Papp JGy, Parratt JR (1999b). Pacing-induced delayed protection against arrhythmias is attenuated by aminoguanidine, an inhibitor of nitric oxide synthase. Br J Pharmacol 127: 1545-1550.
33. Kiss A, Juhász L, Huliák I, Ferdinándy P, Végh Á (2007). Peroxynitrite induces an antiarrhythmic effect in anaesthetised dogs. J Mol Cell Cardiol 42 (Suppl. 1): S9.
34. ATP channel. Am J Physiol Heart Circ Physiol 284: H299-H308.
35. Lee C, Liu X, Zweier JL (2000). Regulation of xanthine oxidase by nitric oxide and peroxynitrite. J Biol Chem 275: 9369-9376.
36. Lefer DJ, Scalia R, Campbell B, Nossuli TO, Hayward R, Salamon M et al. (1997). Peroxynitrite inhibits leucocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats. J Clin Invest 99: 684-691.
37. Liem DA, te Lintel Hekkert M, Mannintveld OC, Boonsma F, Verdouw Pd, Duncker DJ (2005). Myocardium tolerant to an adenosine-dependent ischemic preconditioning stimulus can still be protected by stimuli that employ alternative signaling pathways. Am J Physiol Heart Circ Physiol 288: H1165-H1172.
38. Lim KHH, Javadov SA, Das M, Clarke SJ, Suleiman MS, Halestrap AP (2002). The effects of ischaemic preconditioning, diazoxide and 5-hydroxydecanoate on rat heart mitochondrial volume and respiartion. J Physiol 545: 961-974.
39. Lochner A, Marais E, Genade S, Moolman JA (2000). Nitric oxid: a trigger for classical preconditioning? Am J Physiol Heart Circ Physiol 279: H2752-H2765.
40. Mayer B, Schrammel P, Klatt D, Koesling D, Schmidt K (1995). Peroxynitrite-induced accumulation of cyclic GMP in endothelial cells and stimulation of purified soluble guanylyl cyclase dependence on glutathione and possible role of S-nitrosation. J Biol Chem 270: 17355-17360.
41. Moro MA, Darley-Usmar VM, Lizarain I, Su Y, Knowles RG, Radomski MW et al. (1995). The formation of nitric oxide donors from peroxynitrite. Br J Pharmacol 116: 1999-2004.
42. Niho T, Notsu T, Ishikawa H, Funato H, Yamazaki M, Takahashi H et al. (1987). Study of mechanism and effect of sodium 5-hydroxydecanoate on experimental ischemic ventricular arrhythmia. Nippon Yakurigaku Zasshi 89: 155-167.
43. Nossuli TO, Hayward R, Jensen D, Scalia R, Lefer AM (1998). Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion. Am J Physiol 275: H509-H519.
44. Nossuli TO, Hayward R, Scalia R, Lefer AM (1997). Peroxynitrite reduces myocardial infarct size and preserves coronary endothelium after ischemia and reperfusion in cats. Circulation 96: 2317-2324.
45. ATP channels: role in cardioprotection. Cardiovas Res 55: 429-437.
46. ATP channels triggers the preconditioned state by generating free radicals. Circ Res 91: 186-188.
47. Parratt JR, Végh Á, Kaszala K, Papp JGy (1996). Suppression of life-threatening ventricular arrhythmias by brief periods of ischaemia and by cardiac pacing with particular references to delayed myocardial protection. In: Marber MS, Yellon DM (eds). Ischaemia, Preconditioning and Adaptation. Oxford Bios Scientific Publisher: Oxford, UK. pp 85-111.
48. Poderoso JJ, Carreras MC, Lisdero C, Riobo N, Schopfer F, Boveris A (1996). Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles. Arch Biochem Biophys 328: 85-92.
49. Qiu Y, Rizvi A, Tang XL, Manchikalapudi S, Takano H, Jadoon AK et al. (1997). Nitric oxide triggers late preconditioning against myocardial infarction in conscious rabbits. Am J Physiol 273: H2931-H2936.
50. ATP-dependent mechanism. Am J Physiol Heart Circ Physiol 287: H712-H718.
51. Rastaldo R, Pagliaro P, Cappello S, Penna C, Mancardi D, Westerhof N et al. (2007). Nitric oxide and cardiac function. Life Sci 81: 779-793.
52. Richard V, Tron C, Thuillez C (1993). Ischaemic preconditioning is not mediated by oxygen derived free radicals in rats. Cardiovasc Res 27: 2016-2021.
53. Saavedra WF, Paolocci N, St John ME, Skaf MW, Stewart GC, Xie JS et al. (2002). Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. Circ Res 90: 297-304.
54. Schwartz PJ, Diem R, Dun NJ, Forstermann U (1995). Endogenous and exogenous nitric oxide inhibits norepinephrine release from rat heart sympathetic nerves. Circ Res 77: 841-848.
55. Sears CE, Choate JK, Patterson DJ (1999). NO-cGMP pathway accentuates the decrease in heart rate caused by cardiac vagal nerve stimulation. J Appl Physiol 86: 510-516.
56. Söylemez S, Demiryürek T, Kanzik I (2003). Involvement of tyrosine kinase in peroxynitrite-induced preconditioning in rat isolated heart. Eur J Pharmacol 464: 163-169.
57. Squadrito JS, Pryor WA (1995). The formation of peroxynitrite in vivo from nitric oxide and superoxide. Chem Biol Interact 96: 203-206.
58. Sun J, Morgan M, Shen RF, Steenbergen C, Murphy E (2007). Preconditioning results in S-nitrosylation of proteins involved in regulation of mitochondrial energetics and calcium transport. Circ Res 101: 1155-1163.
59. Szabó C (1996). The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. Shock 6: 79-88.
60. Tanaka M, Fujiwara H, Yamasaki K, Sasayama S (1994). Superoxide dismutase and N-2-mercaptopropionyl glycine attenuate infarct size limitation effect of ischaemic preconditioning in the rabbit. Cardiovasc Res 28: 980-986.
61. Tarpey MM, Beckman JS, Ischiopoulos H, Gore JZ, Brock TA (1995). Peroxynitrite stimulates vascular smooth muscle cell cyclic GMP synthesis. FEBS Lett 364: 314-318.
62. Tecder-Ünal M, Kanzik Y (2004). Peroxynitrite in reperfusion arrhythmias and its whole blood chemiluminescence results. Pharmacol Res 49: 7-16.
63. Uppu RM, Nossaman BD, Greco AJ, Fokin A, Murthy SN, Fonseca VA et al. (2007). Cardiovascular effects of peroxynitrite. Clin Exp Pharmacol Physiol 34: 933-937.
64. Vanden Hoek TL, Becker LB, Shao Z, Li C, Schumacker PT (1998). Reactive oxygen species released from mitochondria during brief hypoxia-induced preconditioning in cardiomyocytes. J Biol Chem 273: 18092-18098.
65. Végh Á, György K, Papp JGy, Sakai K, Parratt JR (1996). Nicorandil suppressed ventricular arrhythmias in a canine model of myocardial ischaemia. Eur J Pharmacol 305: 163-168.
66. Végh Á, Komori S, Szekeres L, Parratt JR (1992a). Antiarrhythmic effects of preconditioning in anaesthetised dogs and rats. Cardiovasc Res 26: 487-495.
67. Végh Á, Papp JGy, Parratt JR (1994). Prevention by dexamethasone of the marked antiarrhythmic effects of preconditioning induced 20 h after rapid cardiac pacing. Br J Pharmacol 113: 1081-1082.
68. Végh Á, Papp JGy, Szekeres L, Parratt JR (1992b). The local intracoronary administration of methylene blue prevents the pronounced antiarrhythmic effect of ischaemic preconditioning. Br J Pharmacol 107: 910-911.
69. Végh Á, Parratt JR (1996). Ischaemic preconditioning markedly reduces the severity of ischaemia and reperfusion-induced arrhythmias; role of endogenous myocardial protective substances. In: Wainwright CL, Parratt JR (eds). Myocardial Preconditioning. Springer: Berlin. pp 35-60.
70. ATP channels in antiarrhythmic effects of ischaemic preconditioning in dogs. Br J Pharmacol 137: 1107-1115.
71. Végh Á, Szekeres L, Parratt JR (1992c). Preconditioning of the ischaemic myocardium; involvement of the L-arginine - nitric oxide pathway. Br J Pharmacol 107: 648-652.
72. Végh Á, Szekeres L, Udvary É (1987). Effect of blood supply to the normal noninfarcted myocardium on the incidence and severity of early postocclusion arrhythmias in dogs. Basic Res Cardiol 82: 159-171.
73. Walker MJA, Curtis MJ, Hearse DJ, Campbell RWF, Janse MJ, Yellon DM et al. (1988). The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia, infarction, and reperfusion. Cardiovasc Res 22: 447-455.
74. Wang PH, Zweier JL (1996). Measurement of nitric oxide and peroxynitrite generation in the postischemic heart: evidence for peroxynitrite mediated reperfusion injury. J Biol Chem 271: 29223-29230.
75. Wit AL, Janse MJ (1993). The Ventricular Arrhythmias of Ischemia and Infarction. Electrophysiological Mechanisms. Futura Publishing Company: Mount Kisco, NY.
76. Wu M, Pritchard KA, Kaminski PM, Fayngersh RP, Hintze TH, Wolin MS (1994). Involvement of nitric oxide and nitrosothiols in relaxation of pulmonary arteries to peroxynitrite. Am J Physiol Heart Circ Physiol 266: H2108-H2113.
77. ATP channels, and ERK. Am J Physiol Heart Circ Physiol 286: H1433-H1440.
78. Yasmin W, Strynadka KD, Schulz R (1997). Generation of peroxynitrite contributes to ischemia-reperfusion injury in isolated rat hearts. Cardiovasc Res 33: 422-432.