Treatment of Crohn's disease with colony-stimulating factors: An overview

Therapeutics and Clinical Risk Management

Volumn 4, Issue 5, 2008, Pages 927-934

  Guidi, Luisa ^a   Mocci, Giammarco ^a   Marzo, Manuela ^a   Rutella, Sergio ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Crohn's disease treatment; G CSF; GM CSF; Inflammatory bowel disease

Indexed keywords

COLONY STIMULATING FACTOR; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PARACETAMOL; PLACEBO; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

BONE PAIN; CELLULAR IMMUNITY; CLINICAL TRIAL; CROHN DISEASE; DRUG DOSE ESCALATION; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; DRUG WITHDRAWAL; GASTROINTESTINAL SYMPTOM; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INJECTION SITE ERYTHEMA; INJECTION SITE REACTION; INNATE IMMUNITY; LEUKOCYTE COUNT; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OUTCOME ASSESSMENT; QUALITY OF LIFE; REGULATORY T LYMPHOCYTE; REVIEW; T LYMPHOCYTE ACTIVATION; TREATMENT DURATION; TREATMENT RESPONSE;

EID: 56749153052     PISSN: 11766336     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (33)

1. Allez M, Mayer L. 2004. Regulatory T-cells: peace-keepers in the gut. Inflamm Bowel Dis, 10:666-76.
2. Brown SJ, Mayer L. 2007. The immune response in inflammatory bowel disease. Am J Gastroenterol, 102:2058-69.
3. + regulatory T-cells in cancer and autoimmunity. Curr Med Chem, 14:649-66.
4. Dejaco C, Lichtenberger C, Miehsler W, et al. 2003. An open-label pilot study of granulocyte colony-stimulating factor for the treatment of severe endoscopic postoperative recurrence in Crohn's disease. Digestion, 68:63-70.
5. Dieckgraefe BK, Korzenik JR. 2002. Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor. Lancet, 360:1478-80.
6. Dieckgraefe BK, Korzenik JR, Husain A, et al. 2002. Association of glycogen storage disease 1b and Crohn disease: results of a North American survey. Eur J Pediatr, 161(Suppl 1):S88-92.
7. Dignass AU, Sturm A. 2001. Peptide growth factors in the intestine. Eur J Gastroenterol Hepatol, 13:763-70.
8. Egi H, Hayamizu K, Yoshimitzu M, et al. 2003. Regulation of T helper type-1 immunity in hapten-induced colitis by host pretreatment with granulocyte colony-stimulating factor. Cytokine, 23:23-30.
9. Ekbom A, Montgomery SM. 2004. Enviromental risk factors (excluding tobacco and microorganisms): critical analysis of old and new hypotheses. Best Pract Res Clin Gastroenterol, 18:497-508.
10. Fukuzawa H, Sawada M, Kayahara T, et al. 2003. Identification of GM-CSF in Paneth cells using single-cell RT-PCR. Biochem Biophys Res Commun, 312:897-902.
11. Harbord MW, Marks DJB, Forbes A, et al. 2006. Impaired neutrophil chemotaxis in Crohn's disease relates to reduced production of chemokines and can be augmented by granulocyte-colony-stimulating factor. Aliment Pharmacol Ther, 24:651-60.
12. Hommes DW, Meenan J, Dijkhuizen S, et al. 1996. Efficacy of recombinant granulocyte colony-stimulating factor (rhG-CSF) in experimental colitis. Clin Exp Immunol, 106:529-33.
13. Hugot JP, Chamaillard M, Zouali H, et al. 2001. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature, 411:599-603.
14. Irving PM, Gibson PR. 2008. Infections and IBD. Nat Clin Pract Gastroenterol Hepatol, 5:18-27.
15. Jonuleit H, Schmitt E. 2003. The regulatory T-cell family: distinct subsets and their interrelations. J Immunol, 171:6323-7.
16. Korzenik JR, Dieckgraefe BK. 2000. Is Crohn's disease an imnmunodeficiency? A hypothesis suggesting possible early events in the pathogenesis of Crohn's disease. Dig Dis Sci, 45:1121-9.
17. Korzenik JR, Dieckgraefe BK. 2005. An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn's disease. Aliment Pharmacol Ther, 21:391-400.
18. Korzenik JR, Dieckgraefe BK, Valentine JF, et al. 2005. Sargramostim for active Crohn's disease. N Engl J Med, 352:2193-201.
19. Marks DJ, Harbord MW, MacAllister R, et al. 2006. Defective acute inflammation in Crohn's disease: a clinical investigation. Lancet, 367:668-78.
20. Morris ES, MacDonald KP, Rowe V, et al. 2004. Donor treatment with pegylated G-CSF augments the generation of IL-10 producing regulatory T-cells and promotes transplantation tolerance. Blood, 103:3573-81.
21. + regulatory T-cells. J Immunol, 170:3939-43.
22. Ogura Y, Bonen DK, Inohara N, et al. 2001. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature, 411:603-6.
23. Playford RJ, Ghosh S. 2005. Cytokines and growth factor modulators in intestinal inflammation and repair. J Pathol, 205:417-25.
24. Podolsky DK. 2002. Inflammatory bowel disease. N Engl J Med, 347:417-29.
25. + regulatory cells that control intestinal inflammation. J Exp Med, 192:295-302.
26. Rutella S. 2007. Granulocyte colony-stimulating factor for the induction of T-cell tolerance. Transplantation, 84:S26-S30.
27. Rutella S, Pierelli L, Bonanno G, et al. 2002. Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cells. Blood, 100:2562-71.
28. Sainathan SK, Hanna EM, Gong Q, et al. 2008. Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis. Inflamm Bowel Dis, 14:88-99.
29. Satsangi J, Morecroft J, Shah NB, et al. 2003. Genetics of inflammatory bowel disease: scientific and clinical implications. Best Pract Res Clin Gastroenterol, 17:3-18.
30. Vaughan D, Drumm B. 1999. Treatment of fistulas with granulocyte colony-stimulating factor in a patient with Crohn's disease. N Engl J Med, 340:239-40.
31. Visser G, Rake JP, Labrune P, et al. 2002. Granulocyte colony-stimulating factor in glycogen storage disease type 1b. Results of the European Study on Glycogen Storage Disease Type 1. Eur J Pediatr, 161(Suppl 1):S83-7.
32. Wilk SN, Viney JL. 2002. GM-CSF treatment for Crohn's disease: a stimulating new therapy? Curr Opin Investig Drugs, 3:1291-6.
33. Yamaguchi T, Ihara K, Matsumoto T, et al. 2001. Inflammatory bowel disease-like colitis in glycogen storage disease type 1b. Inflamm Bowel Dis, 7:128-32.