Oxidative stress potentiated by diallylsulfide, a selective CYP2E1 inhibitor, in isoniazid toxic effect on rat primary hepatocytes

Toxicology Letters

Volumn 183, Issue 1-3, 2008, Pages 95-98

  Zhai, Qing ^a,b,c   Lu, Sheng Rong ^c   Lin, Yi ^c   Yang, Qi Lian ^a,c   Yu, Bo ^a,c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^c Minhang Central Hospital   (China)

Author keywords

Diallylsulfide; Hepatocytotoxicity; Isoniazid (INH); Oxidative stress; Rat primary hepatocytes

Indexed keywords

CYTOCHROME P450 2E1; DIALLYLSULFIDE; ENZYME INHIBITOR; GLUTATHIONE; ISONIAZID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; LIVER CELL; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ALLYL COMPOUNDS; ANIMALS; ANTITUBERCULAR AGENTS; CELL COUNT; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROME P-450 CYP2E1; DRUG SYNERGISM; GLUTATHIONE; HEPATOCYTES; ISONIAZID; MALE; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SULFIDES; TIME FACTORS;

RATTUS;

EID: 56549124192     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.10.007     Document Type: Article

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