Differential role of CYP2E1 binders and isoniazid on CYP2E1 protein modification in NADPH-dependent microsomal oxidative reactions: Free radical scavenging ability of isoniazid

Free Radical Research

Volumn 36, Issue 8, 2002, Pages 893-903

  Choi, Dal Woong ^a   Leininger Muller, Brigitte ^b   Kim, Young Chul ^c   Leroy, Pierre ^a   Siest, Gerard ^c   Wellman, Maria ^c  

^a INSERM   (France)

^b Seoul National University   (South Korea)

^c Thiols Et Fonctions Celluloizes ^*

Author keywords

"Tight" binders; "Weak" binders; CYP2E1 protein modification; Isoniazid; LPO; ROS

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; 4 METHYLPYRAZOLE; ACETOACETIC ACID DERIVATIVE; ACETONE; ALCOHOL; CARBON TETRACHLORIDE; CYTOCHROME P450 2E1; GLYCEROL; HYDROXYL RADICAL; IMIDAZOLE; IRON CHELATING AGENT; ISONIAZID; MALONALDEHYDE; PROTEINASE; PYRIDINE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SCAVENGER;

ANIMAL CELL; ARTICLE; CELL STRAIN HEPG2; CHEMICAL REACTION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE; GENETIC TRANSFECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER MICROSOME; MALE; MICROSOME; NONHUMAN; OXIDATION; PROTEIN MODIFICATION; PROTEIN STABILITY; RAT;

ANIMALS; CELL LINE; CELLS, CULTURED; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICALS; HUMANS; ISONIAZID; LIPOPOLYSACCHARIDES; LIVER; MALE; MICROSOMES; NADP; OXYGEN; PROTEASE INHIBITORS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; TRANSFECTION;

ANIMALIA; LETHRINIDAE;

EID: 0036681836     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/1071576021000005339     Document Type: Article

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