Exploring the regime map for high-shear mixer granulation

Chemical Engineering Journal

Volumn 145, Issue 3, 2009, Pages 505-513

  Tu, Wei Da ^a   Ingram, Andy ^b   Seville, Jonathan ^c   Hsiau, Shu San ^a  

^a NATIONAL CENTRAL UNIVERSITY   (Taiwan)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Agglomeration; Granule size distribution; Growth behaviour; GSD; High shear mixer; Regime map; Sieving

Indexed keywords

AGGLOMERATION; CELLULOSE DERIVATIVES; ETHYLENE GLYCOL; GLYCOLS; GRANULATION; MIXERS (MACHINERY); MIXING; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SIZE DISTRIBUTION;

GRANULE SIZE DISTRIBUTION; GROWTH BEHAVIOUR; GSD; HIGH-SHEAR MIXER; REGIME MAP; SIEVING;

MAPS;

AGGLOMERATION; CELLULOSE DERIVATIVES; ETHYLENE GLYCOL; GLYCOLS; GRANULATION; GRANULES; GROWTH; MAPS; MIXERS; MIXING; POLYETHYLENE GLYCOL; POLYETHYLENE OXIDE;

EID: 56549115456     PISSN: 13858947     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cej.2008.09.033     Document Type: Article

References (32)

1. Iveson S.M., and Litster J.D. Growth regime map for liquid-bound granules. AIChE Journal 44 (1998) 1510-1518
2. Iveson S.M., Wauters P.A.L., Forrest S., Litster J.D., Meesters G.M.H., and Scarlett B. Growth regime map for liquid-bound granules: further development and experimental validation. Powder Technology 117 (2001) 83-97
3. Holt E.M. The properties and forming of catalysts and absorbents by granulation. Powder Technology 140 (2004) 194-202
4. Lee T., Hou H.J., Hsieh H.Y., Su Y.C., Wang Y.W., and Hsu F.B. The prediction of the dissolution rate constant by mixing rules: the study of acetaminophen batches. Drug Development and Industrial Pharmacy 34 (2008) 522-535
5. Lee T., and Hsu F.B. A cross-performance relationship between Carr's index and dissolution rate constant: the study of acetaminophen batches. Drug Development and Industrial Pharmacy 33 (2007) 1273-1284
6. Muzzio F.J., Shinbrot T., and Glasser B.J. Powder technology in the pharmaceutical industry: the need to catch up fast. Powder Technology 124 (2002) 1-7
7. Leuenberger H., and Lanz M. Pharmaceutical powder technology-from art to science: the challenge of the FDA's Process Analytical Technology initiative. Advanced Powder Technology 16 (2005) 3-25
8. Rough S.L., Wilson D.I., Bayly A.E., and York D.W. Mechanisms in high-viscosity immersion-granulation. Chemical Engineering Science 60 (2005) 3777-3793
9. Iveson S.M., Litster J.D., Hapgood K., and Ennis B.J. Nucleation, growth and breakage phenomena in agitated wet granulation processes: a review. Powder Technology 117 (2001) 3-39
10. Vonk P., Guillaume C.P.F., Ramaker J.S., Vromans H., and Kossen N.W.F. Growth mechanisms of high-shear pelletisation. International Journal of Pharmaceutics 157 (1997) 93-102
11. Hoornaert F., Wauters P.A.L., Meesters G.M.H., Pratsinis S.E., and Scarlett B. Agglomeration behaviour of powders in a Lodige mixer granulator. Powder Technology 96 (1998) 116-128
12. Goldszal A., and Bousquet J. Wet agglomeration of powders: from physics toward process optimization. Powder Technology 117 (2001) 221-231
13. Iveson S.M., Beathe J.A., and Page N.W. The dynamic strength of partially saturated powder compacts: the effect of liquid properties. Powder Technology 127 (2002) 149-161
14. Hapgood K.P., Litster J.D., Biggs S.R., and Howes T. Drop penetration into porous powder beds. Journal of Colloid and Interface Science 253 (2002) 353-366
15. Wildeboer W.J., Litster J.D., and Cameron I.T. Modelling nucleation in wet granulation. Chemical Engineering Science 60 (2005) 3751-3761
16. Bouwman A.M., Visser M.R., Meesters G.M.H., and Frijlink H.W. The use of Stokes deformation number as a predictive tool for material exchange behaviour of granules in the 'equilibrium phase' in high shear granulation. International Journal of Pharmaceutics 318 (2006) 78-85
17. Hounslow M.J., Pearson J.M.K., and Instone T. Tracer studies of high-shear granulation. II. Population balance modeling. AIChE Journal 47 (2001) 1984-1999
18. Iveson S.M. Limitations of one-dimensional population balance models of wet granulation processes. Powder Technology 124 (2002) 219-229
19. Liu X., and Litster D. Population balance modelling of granulation with a physically based coalescence kernel. Chemical Engineering Science 57 (2002) 2183-2191
20. Verkoeijen D., Pouw G.A., Meesters G.M.H., and Scarlett B. Population balances for particulate processes-a volume approach. Chemical Engineering Science 57 (2002) 2287-2303
21. Wauters P.A.L., Scarlett B., Liu L.X., Litster J.D., and Meesters G.M.H. A population balance model for high shear granulation. Chemical Engineering Communications 190 (2003) 1309-1334
22. Darelius A., Rasmuson A., Björn I.N., and Folestad S. High shear wet granulation modelling-a mechanistic approach using population balances. Powder Technology 160 (2005) 209-218
23. Darelius A., Brage H., Rasmuson A., Björn I.N., and Folestad S. A volume-based multi-dimensional population balance approach for modelling high shear granulation. Chemical Engineering Science 61 (2006) 2482-2493
24. Poon J.M.H., Immanuel C.D., Doyle F.J.I., and Litster J.D. A three-dimensional population balance model of granulation with a mechanistic representation of the nucleation and aggregation phenomena. Chemical Engineering Science 63 (2008) 1315-1329
25. Knight P.C., Seville J.P.K., Wellm A.B., and Instone T. Prediction of impeller torque in high shear powder mixers. Chemical Engineering Science 56 (2001) 4457-4471
26. Bridson R.H., Robbins P.T., Chen Y., Westerman D., Gillham C.R., Roche T.C., and Seville J.P.K. The effects of high shear blending on alpha-lactose monohydrate. International Journal of Pharmaceutics 339 (2007) 84-90
27. Saleh K., Vialatte L., and Guigon P. Wet granulation in a batch high shear mixer. Chemical Engineering Science 60 (2005) 3763-3775
28. Knight P.C. An investigation of the kinetics of granulation using a high shear mixer. Powder Technology 77 (1993) 159-169
29. Allen T. Particle Size Measurement, Powder Sampling and Particle Size Measurement (1997), Chapman & Hall
30. Tardos G.I., Hapgood K.P., Ipadeola O.O., and Michaels J.N. Stress measurements in high-shear granulators using calibrated "test" particles: application to scale-up. Powder Technology 140 (2004) 217-227
31. Hapgood K.P., Iveson S.M., Litster J.D., and Liu L.X. Granulation rate processes. In: Salman A.D., Hounslow M.J., and Seville J.P.K. (Eds). Granulation (2007), Elsevier, Amsterdam 897-978
32. Rough S.L., Wilson D.I., and York D.W. A regime map for stages in high shear mixer agglomeration using ultra-high viscosity binders. Advanced Powder Technology 16 (2005) 373-386