Growth mechanisms of high-shear pelletisation

International Journal of Pharmaceutics

Volumn 157, Issue 1, 1997, Pages 93-102

  Vonk, P ^a   Guillaume, C P F ^a   Ramaker, J S ^a   Vromans, H ^a   Kossen, N W F ^a  

^a Ant Deusinglaan 1 ^*  (Netherlands)

Author keywords

Growth mechanism; High shear mixer; Kinetics; Nucleation; Pelletisation

Indexed keywords

LACTOSE; MICROCRYSTALLINE CELLULOSE;

ARTICLE; DRUG GRANULATION; GROWTH; PARTICLE SIZE; PELLET EXTRUSION; PHYSICAL PHENOMENA; PRESSURE; PRIORITY JOURNAL; STEADY STATE; TENSILE STRENGTH;

EID: 0030860304     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00232-9     Document Type: Article

References (25)

1. Adetayo A.A., Litster J.D., Desai M. The effect of process parameters on drum granulation of fertilizers with broad size distributions. Chem. Eng. Sci. 48:1993;3951-3961.
2. Adetayo A.A., Litster J.D., Pratsinis S.E., Ennis B.J. Population balance modelling of drum granulation of materials with wide size distribution. Powder Technol. 82:1995;37-49.
3. Carstensen J.T., Lai T., Flickner D.W., Huber H.E., Zoglio M.A. Physical aspects of wet granulation I: Distribution kinetics of water. J. Pharm. Sci. 65:1976;992-997.
4. Ek R., Alderborn G., Nyström C. Particle analysis of microcrystalline cellulose: Differentiation between individual particles and their agglomerates. Int. J. Pharm. 111:1994;43-50.
5. Ennis B.J. Agglomeration and size enlargement. Session summary paper. Powder Technol. 88:1996;203-225.
6. Hancock B.C., York P., Rowe R.C. Characterization of wet masses using a mixer torque rheometer: 2. mixing kinetics. Int. J. Pharm. 83:1992;147-153.
7. Holm P., Jungersen O., Schæfer T., Kristensen H.G. Granulation in high-speed mixers. Part I. Effects of process variables during kneading. Pharm. Ind. 45:1983;806-811.
8. Holm P., Schæfer T., Kristensen H.G. Granulation in high-speed mixers. Part VI. Effects of process conditions on power consumption and granule growth. Powder Technol. 43:1985;225-233.
9. Holm P. Pelletization by granulation in a roto-processor RP-2. Part I: Effects of process and product variables on granule growth. Pharm. Technol. Eur. 8:1996;22-36.
10. st International Particle Technology Forum, vol. 1, Denver, CO, pp. 278-283.
11. Kapur P.C., Fuerstenau D.W. Size distributions and kinetic relationships in the nuclei region of wet pelletization. Ind. Eng. Chem. Process Des. Dev. 5:1966;5-10.
12. Knight P.C. An investigation of the kinetics of granulation using a high shear mixer. Powder Technol. 77:1993;159-169.
13. st World Meeting APGI/APV, Budapest, pp. 151-152.
14. Leuenberger H., Imanidis G. Monitoring mass transfer processes to control moist agglomeration. Pharm. Technol. March:1986;56-73.
15. Newton J.M., Chapman S.R., Rowe R.C. The influence of process variables on the preparation and properties of spherical granules by the process of extrusion and spheronisation. Int. J. Pharm. 120:1995;101-109.
16. Ouchiyama N., Tanaka T. The probability of coalescence in granulation kinetics. Ind. Eng. Chem. Process Des. Dev. 14:1975;286-289.
17. Potapov A.V., Campbell C.S. Computer simulation of impact-induced particle breakage. Powder Technol. 81:1994;207-216.
18. Sastry, K.V.S., Fürstenau, D.W., 1977. Kinetic and process analysis of the agglomeration of particulate materials of green pelletization. In: Sastry, K.V.S. (Ed.), Agglomeration 77. AIME, New York, pp. 381-402.
19. Schæfer T., Holm P., Kristensen H.G. Melt pelletization in a high shear mixer. II. Power consumption and granule growth. Acta Pharm. Nordica. 4:1992;141-148.
20. Schæfer T., Taagegaard B., Thomsen L.J., Kristensen H.G. Melt pelletization in a high shear mixer. V. Effect of apparatus variables. Eur. J. Pharm. Sci. 1:1993;133-141.
21. Schæfer, T., Mathiesen, C., 1996. Melt pelletization in a high shear mixer. VIII. Effects of binder viscosity. Int. J. Pharm. 139, 125-138.
22. Schubert, H., Heidenreich, E., Neeße, T., 1990. Mechanische Verfahrenstechnik. Deutscher Verlag für Grundstoffindustrie, Leipzig.
23. Thornton C., Yin K.K., Adams M.J. Numerical simulation of the impact fracture and fragmentation of agglomerates. J. Phys. D: Appl. Phys. 29:1996;424-435.
24. Vertommen J., Kinget R. The influence of five selected processing and formulation variables on the release of riboflavin from pellets produced in a rotary processor. S. T. P. Pharma Sci. 6:1996;335-340.
25. Vervaet C., Baert L., Remon J.P. Extrusion-spheronisation. A literature review. Int. J. Pharm. 116:1995;131-146.