5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens

Pharmacology Biochemistry and Behavior

Volumn 72, Issue 1-2, 2002, Pages 29-37

  Rabin, Richard A ^a   Regina, Meredith ^a   Doat, Mireille ^a   Winter, J C ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

5 HT2A receptor; Arachidonic acid release; Drug discrimination; Hallucinogens; Phosphoinositide hydrolysis

Indexed keywords

2,5 DIMETHOXY 4 METHYLAMPHETAMINE; 5 METHOXY N,N DIMETHYLTRYPTAMINE; 6 FLUORO N,N DIETHYLTRYPTAMINE; BETA CARBOLINE DERIVATIVE; BROMOLYSERGIDE; HARMALINE; HARMAN; INOSITOL PHOSPHATE; LISURIDE; LYSERGIDE; N,N DIETHYLTRYPTAMINE; N,N DIMETHYLTRYPTAMINE; PHOSPHATIDYLINOSITIDE; PSILOCYBINE; PSYCHEDELIC AGENT; QUIPAZINE; SEROTONIN 2A RECEPTOR; TRITIUM; TRYPTAMINE DERIVATIVE; UNCLASSIFIED DRUG; PHOSPHATIDYLINOSITOL; SEROTONIN RECEPTOR;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DISCRIMINATION; DRUG EFFECT; DRUG EFFICACY; LIPID HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STIMULUS RESPONSE; ANIMAL; CELL STRAIN; DOSE RESPONSE; HYDROLYSIS; METABOLISM;

ANIMALIA;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HALLUCINOGENS; HYDROLYSIS; PC12 CELLS; PHOSPHATIDYLINOSITOLS; RATS; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN;

EID: 0036202483     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(01)00720-1     Document Type: Article

References (51)

1. 2A receptor activation of the mitogen-activated protein kinase pathway in vascular smooth muscle
2. 5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms
3. Signal transduction differences between 5-hydroxytryptamine type 2A and type 2C receptor systems
4. Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: Evidence for agonist-directed trafficking of receptor stimulus
5. Role of serotonin in the discriminative stimulus properties of mescaline
6. 2) receptor binding sites in cerebellar granule neurons: Involvement of calcium influx and a calmodulin-dependent pathway
7. Regulation of serotonin-stimulated phosphoinositide hydrolysis: Relation to the serotonin 5-HT-2 binding site
8. 2) receptor stimulates inositol phosphate formation in intact and broken WRK1 cells: Determination of occupancy-response relationships for 5-HT agonists
9. Continuous subcutaneous lisuride infusions in Parkinson's disease
10. Effect of lisuride on inhibition of lactation and serum prolactin
11. 2C receptors
12. Clinical evaluation of some hallucinogenic tryptamine derivatives
13. 2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis
14. 2C receptors in the stimulus effects of hallucinogenic drugs: I. Antagonist correlation analysis
15. 2C receptors in the stimulus effects of hallucinogenic drugs: II. Reassessment of LSD false positives
16. 3 receptors in PC12 cells treated with NGF and 8-BR-cAMP
17. 2A receptor in rat C6 glioma cells
18. DOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines
19. 2 involvement in the mechanism of action of hallucinogenic agents
20. 2A receptors
21. 3 recognition sites in rat pheochromocytoma (PC12) cells
22. Investigation of hallucinogenic and related β-carbolines
23. 3 receptors in rodents
24. 2A component of the ibogaine-induced discriminative stimulus
25. A comparison of N,N-dimethyltryptamine, harmaline, and selected congeners in rats trained with LSD as a discriminative stimulus
26. Clinical effectiveness of lisuride hydrogen maleate: A double-blind trial versus methysergide
27. 5-Hydroxytryptamine induces TIS8/erg-1 and c-fos expression in PC12 cells. Involvement of tyrosine protein phosphorylation
28. Effects of chronic cocaine administration on the serotonergic system in the rat brain
29. The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors
30. Differential effects of chronic ethanol exposure on ATP- and bradykinin-induced increases in intracellular calcium levels in PC-12 cells
31. Psychiatric side effects during the treatment of Parkinson's disease
32. Discriminative stimulus properties of hallucinogens: Behavioral assay of drug action
33. 2A receptors on interneurons in rat piriform cortex
34. 2C receptors expressed in the human neuroblastoma cell line SH-SY5Y: Comapartive stimulation by hallucinogenic drugs
35. Behavioral and biochemical evidence for serotonergic actions of tetrahydro-β-carbolines
36. Subcutaneous administration of lisuride in the treatment of complex motor fluctuations in Parkinson's disease
37. Neuroendocrine effects of quipazine in man in health state or with neurological disorders
38. Structure and functional expression of cloned rat serotonin 5HT-2 receptor
39. Chronic ethanol exposure of PC 12 cells alters adenylate cyclase activity and cyclic AMP content
40. 2 receptors: Implications for treating LSD-induced hallucinogenesis
41. Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis
42. Blockade of the discriminative stimulus effects of DOI by MDL 100,907 and the 'atypical' antipsychotics clozapine and risperidone
43. Coupling of I1 imidazole receptors to diacylglyceride accumulation in PC12 rat pheochromocytome cells
44. Activation of phosphatidylcholine-selective phospholipase C by I1-imidazole receptors in PC12 cells and rostral ventrolateral medulla
45. 2C, receptor
46. 2 receptor subtypes
47. 2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens
48. Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line
49. Blockade of the stimulus properties of mescaline by a serotonin antagonist
50. Drug induced stimulus control
51. Serotonergic receptor subtyopes and hallucinogen-induced stimulus control