Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: Design, synthesis, and BK channel-opening activity

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 24, 2008, Pages 6386-6389

  Cui, Yong Mei ^a   Yasutomi, Eriko ^a   Otani, Yuko ^a   Yoshinaga, Takashi ^b   Ido, Katsutoshi ^b   Sawada, Kohei ^b   Kawahata, Masatoshi ^c   Yamaguchi, Kentaro ^c   Ohwada, Tomohiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b EISAI CO LTD   (Japan)

^c TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

12,14 Dichlorodehydroabietic acid; BK channels; Openers; Oxime; Oxime ether

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; 12,14 DICHLORODEHYDROABIETIC ACID; ABIETIC ACID; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; OXIME DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CHEMICAL MODIFICATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; NONHUMAN; PATCH CLAMP; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; DITERPENES, ABIETANE; DRUG DESIGN; ETHERS; HYDROGEN; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; OXIMES; PATCH-CLAMP TECHNIQUES;

EID: 56549103041     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.078     Document Type: Article

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