Novel BK channel openers containing dehydroabietic acid skeleton: Structure-activity relationship for peripheral substituents on ring C

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 19, 2008, Pages 5201-5205

  Cui, Yong Mei ^a   Yasutomi, Eriko ^a   Otani, Yuko ^a   Yoshinaga, Takashi ^b   Ido, Katsutoshi ^b   Sawada, Kohei ^b   Ohwada, Tomohiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b EISAI CO LTD   (Japan)

Author keywords

BK channels; Dehydroabietic acid; Openers; SAR studies; Thiourea

Indexed keywords

DEHYDROABIETIC ACID; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; NITRO DERIVATIVE; POTASSIUM CHANNEL STIMULATING AGENT; THIOUREA DERIVATIVE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; HYDROPHOBICITY; ION CURRENT; NONHUMAN; PROTEIN EXPRESSION; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARBOXYLIC ACIDS; COMBINATORIAL CHEMISTRY TECHNIQUES; CRICETINAE; CRICETULUS; DITERPENES, ABIETANE; ION CHANNEL GATING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PATCH-CLAMP TECHNIQUES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 52049120130     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.078     Document Type: Article

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