Design, synthesis and characterization of podocarpate derivatives as openers of BK channels

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 19, 2008, Pages 5197-5200

  Cui, Yong Mei ^a   Yasutomi, Eriko ^a   Otani, Yuko ^a   Yoshinaga, Takashi ^b   Ido, Katsutoshi ^b   Sawada, Kohei ^b   Ohwada, Tomohiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b EISAI CO LTD   (Japan)

Author keywords

BK channels; Channel openers; Podocarpic acid

Indexed keywords

ABIETIC ACID; CARBOXYLIC ACID; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; MAXIKDIOL; PIMARIC ACID; PODOCARPIC ACID DERIVATIVE; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONFORMATION; DRUG DESIGN; DRUG SYNTHESIS; HYDROPHOBICITY; ION CURRENT; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

CARBOXYLIC ACIDS; COMBINATORIAL CHEMISTRY TECHNIQUES; DITERPENES; DITERPENES, ABIETANE; ION CHANNEL GATING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PATCH-CLAMP TECHNIQUES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 52049083015     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.081     Document Type: Article

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