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Acetylcholinesterases - The structural similarities and differences
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Mineralization of paraoxon and its use as a sole C and P source by a rationally designed catabolic pathway in Pseudomonas putida
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Organophosphates/nerve agent poisoning: Mechanism of action, diagnosis, prophylaxis, and treatment
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Structural requirements of acetylcholinesterase reactivators
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Kuca, K., Jun, D. and Musilek, K. (2006) Structural requirements of acetylcholinesterase reactivators. Mini Rev Med Chem, 6, pp. 269-277.
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Treatment of organophosphate intoxication using cholinesterase reactivators: Facts and fiction
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Bajgar, J., Fusek, J., Kuca, K., Bartosova, L. and Jun, D. (2007) Treatment of organophosphate intoxication using cholinesterase reactivators: Facts and fiction. Mini Rev Med Chem, 7, pp. 461-466.
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Currently used cholinesterase reactivators against nerve agent intoxication: Comparison of their effectivity in vitro
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Kuca, K., Jun, D. and Bajgar, J. (2007) Currently used cholinesterase reactivators against nerve agent intoxication: Comparison of their effectivity in vitro. Drug Chem Toxicol, 30, pp. 31-40.
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Test with Daphnia magna: A new approach to prescreen toxicity of newly synthesized acetylcholinesterase reactivotors
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Vesela, S., Ondruska, V., Kuca, K. and Patocka, J. (2006) Test with Daphnia magna: A new approach to prescreen toxicity of newly synthesized acetylcholinesterase reactivotors. J Enz Inhib Med Chem, 21, pp. 427-432.
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Amperometric biosensor for evaluation of competitive cholinesterase inhibition by the reactivator HI-6
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Pohanka, M., Jun, D. and Kuca, K. (2007) Amperometric biosensor for evaluation of competitive cholinesterase inhibition by the reactivator HI-6. Anal Lett., 40, pp. 2351-2359.
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New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin
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Hrabinova, M., Musilek, K., Jun, D. and Kuca, K. (2006) New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin. J Enz Inhib Med Chem, 21, pp. 512-519.
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A comparison of the ability of a new bispyridinium oxime-1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods
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Kuca, K. and Kassa, J. (2003) A comparison of the ability of a new bispyridinium oxime-1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods. J Enz Inhib Med Chem, 18, pp. 529-535.
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A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun- poisoned rats
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Kassa, J., Jun, D. and Kuca, K. (2007) A comparison of reactivating efficacy of newly developed oximes (K074, K075) and currently available oximes (obidoxime, HI-6) in cyclosarin-and tabun- poisoned rats. J Enz Inhib Med Chem, 22, pp. 297-300.
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Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase
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Musilek, K., Holas, O., Kuca, K., Jun, D., Dohnal, V. and Dolezal, M. (2007) Synthesis of a novel series of non-symmetrical bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase. J Enz Inhib Med Chem, 22, pp. 425-432.
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Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases
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Kuca, K., Cabal, J., Jun, D., Bajgar, J. and Hrabinova, M. (2006) Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases. J Enz Inhib Med Chem, 21, pp. 663-666.
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Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase
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Musilek, K., Kuca, K., Jun, D., Dohnal, V. and Dolezal, M. (2005) Synthesis of a novel series of bispyridinium compounds bearing a xylene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase. J Enz Inhib Med Chem, 20, pp. 409-415.
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A new group of monoquaternary reactivators of acetylcholinesterase inhibited by nerve agents
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Picha, J., Kuca, K., Kivala, M., Kohout, M., Cabal, J. and Liska, F. (2005) A new group of monoquaternary reactivators of acetylcholinesterase inhibited by nerve agents. J Enz Inhib Med Chem, 20, pp. 233-237.
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Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes
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Kuca, K. and Patocka, J. (2004) Reactivation of cyclosarin-inhibited rat brain acetylcholinesterase by pyridinium-oximes. J Enz Inhib Med Chem, 19, pp. 39-43.
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In vitro reactivation of sarin-inhibited brain acetylcholinesterase from diferent species by various oximes
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Kuca, K., Cabal, J. and Kassa, J. (2005) In vitro reactivation of sarin-inhibited brain acetylcholinesterase from diferent species by various oximes. J Enz Inhib Med Chem, 20, pp. 227-232.
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