Tests with Daphnia magna: A new approach to prescreen toxicity of newly synthesized acetylcholinesterase reactivators

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 21, Issue 4, 2006, Pages 427-432

  Vesela, Sarka ^a,b   Ondruska, Vlastimil ^a   Kuca, Kamil ^b   Patocka, Jiri ^b,c  

^a Research and Development Centre Hostivice   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c UNIVERSITY OF SOUTH BOHEMIA   (Czech Republic)

Author keywords

Acetylcholine; Antidotes; Crustacean; Inhibition; Organophosphate intoxications; Oximes; Toxicity tests

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 (4 HYDROXYIMINOMETHYLPYRIDINIUM) 3 (4 CARBAMOYLPYRIDINIUM)PROPANE DIBROMIDE; 1 (4 HYDROXYIMINOMETHYLPYRIDINIUM) 4 (4 CARBAMOYLPYRIDINIUM)BUTANE DIBROMIDE; 1,4 BIS(2 HYDROXYIMINOMETHYLPYRIDINIUM)BUTANE DIBROMIDE; CHOLINESTERASE REACTIVATOR; K 027; K 033; K 048; OBIDOXIME; ORGANOPHOSPHATE; OXIME DERIVATIVE; PRALIDOXIME CHLORIDE; TRIMEDOXIME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; COST BENEFIT ANALYSIS; DAPHNIA; DRUG SCREENING; DRUG STRUCTURE; EXPERIMENTAL ANIMAL; FEMALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TOXICITY TESTING;

ACETYLCHOLINESTERASE; ANIMALS; CHOLINESTERASE REACTIVATORS; CRUSTACEA; DAPHNIA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; FEMALE; MODELS, CHEMICAL; OXIMES; PHOSPHORIC ACID ESTERS; TOXICITY TESTS;

ANIMALIA; CRUSTACEA; DAPHNIA MAGNA; DAPHNIIDAE;

EID: 33744812785     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360500381194     Document Type: Article

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