Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 21, Issue 6, 2006, Pages 663-666

  Kuca, Kamil ^a   Cabal, Jiri ^a   Jun, Daniel ^a   Bajgar, Jiri ^a   Hrabinova, Martina ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Cholinesterase; Cyclosarin; Human brain; Inhibition; Nerve agent; Reactivator

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 (4 HYDROXYIMINOMETHYLPYRIDINIUM) 3 (4 CARBAMOYLPYRIDINIUM)PROPANE DIBROMIDE; 1 (4 HYDROXYIMINOMETHYLPYRIDINIUM) 4 (4 CARBAMOYLPYRIDINIUM)BUTANE DIBROMIDE; 1,4 BIS(2 HYDROXYIMINOMETHYLPYRIDINIUM)BUTANE DIBROMIDE; 1,4 BIS(4 HYDROXYIMINOMETHYLPYRIDINIUM)BUT 2 ENE DIBROMIDE; 1,4 BIS(4 HYDROXYIMINOMETHYLPYRIDINIUM)BUTANE DIBROMIDE; ACETYLCHOLINESTERASE; CHOLINESTERASE REACTIVATOR; CYCLOSARIN; K 027; K 033; K 048; K 074; K 075; OXIME DERIVATIVE; PRALIDOXIME;

ARTICLE; BRAIN HOMOGENATE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME REACTIVATION; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL;

ACETYLCHOLINESTERASE; BRAIN; CHOLINESTERASE INHIBITORS; CHOLINESTERASE REACTIVATORS; HUMANS; KINETICS; ORGANOPHOSPHORUS COMPOUNDS; OXIMES; PRALIDOXIME COMPOUNDS; PYRIDINIUM COMPOUNDS;

ANIMALIA; RODENTIA;

EID: 33845776174     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360600850916     Document Type: Article

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